Coordinating Center: Molecular and Cellular Findings of Screen-Detected Lesions

 描述（由申请人提供）：筛选检出病变的分子和细胞表征-协调中心和数据管理小组将为响应RFA CA 14 - 10的参与研究提供支持。协调中心支持三个主要领域：网络协调、统计支持和计算分析以及协议开发和数据库支持。通过交互式门户网站、电话会议管理和会议支持提供通信支持。协调中心还为泛网络研究开发协议和数据库。协调中心通过为研究人员提供最先进的分析设施和软件来支持整个联盟的数据分析。集群计算， Discovery集群将支持下一代分析、高维分析和模拟。将通过访问用户友好型软件的研究中心许可证以及已经和将根据用户要求构建的图形用户界面沿着，提供生物信息学分析支持。在可能的情况下，将使用Biodatomics Enterprise软件开发管理生物标志物分析的工作流程，因为该过程已存储，并且可以直接集成R软件支持。统计支助将通过协调中心提供统计方法的制定和应用准则。 数据库支持由分析小组提供，该小组一直与喷气推进实验室合作支持早期探测研究网络。协调中心将为制定协议提供支持，达特茅斯CTSA将提供额外支持。

 DESCRIPTION (provided by applicant): The Molecular and Cellular Characterization of Screen‐Detected Lesions ‐ Coordinating Center and Data Management Group will provide support for the participating studies responding to RFA CA14‐10. The coordinating center supports three main domains: network coordination, statistical support and computational analysis and protocol development and database support. Support for communication is provided through an interactive web portal, management of conference calls, and meeting support. The coordinating center also develops protocols and databases for pan network studies. The coordinating center supports analysis of data across the consortium by providing access by researchers to state of the art analytical facilities and software. Cluster computing for next generation analysis, high dimensional analyses and simulations will be supported on the Discovery cluster. Support for bioinformatical analyses will be provided through access to site licenses for user friendly software along with graphical user interfaces that have been and will be built as required by users. Workflows for managing biomarker analysis will be developed using Biodatomics Enterprise software, where possible, because the process is stored and R software support can be directly integrated. Guidelines for the development and application of statistical approaches will be provided by the statistical support through the coordinating center. Database support is provided by the analytical team that has been supporting the Early Detection Research Network in collaboration with the Jet Propulsion Laboratory. Support for the development of protocols will be provided by the Coordinating Center and with additional support from the Dartmouth CTSA.