Training Grant in Circadian and Sleep Research

描述(由申请人提供)：这是重新提交的续签申请，以继续支持已设立的T32昼夜节律和睡眠研究培训助学金，以培训和支持西北大学(NU)和芝加哥大学(U Of C)的博士后和博士后学生。20多年来，动物模型和人类中昼夜节律生物学和睡眠研究的整合一直是加州大学和北卡罗来纳大学这一培训补助金上的教官之间关系的基石，我们在我们的培训计划的标题中增加了“昼夜节律”一词，以认识到在培训下一代年轻研究人员时将这些领域结合起来的重要性。这次培训 该计划将由多重领导计划下的两名资深调查人员领导，并将涉及13个初级培训学院，他们的主要任命在基础科学或临床部门。拟议的培训计划将为博士后和博士后学生提供广泛的科学学科的跨学科和多学科培训，这些学科与理解睡眠和昼夜节律性的功能、调节和健康影响高度相关。该项目的核心是对学生进行现代基础科学、转化性研究以及以病人为中心的研究的培训。十多年来，多个研究视角推动了这一计划中的教导者之间的生产性互动和交叉受精。在目前的资助期间，培训学院的研究活动范围已经扩大到包括睡眠障碍呼吸对新陈代谢和心血管功能的影响的工作台到床边的调查，我们建议在我们的新计划中进一步扩大计划，在培训学院增加6名杰出的内科科学家。由于我国正面临前所未有的肥胖、糖尿病及其心血管后果的流行，本申请中提出的培训计划具有独特的定位，可以培训一支由学术和行业调查人员以及政府决策者组成的跨学科队伍，以应对睡眠障碍和昼夜节律失调在这些公共卫生挑战中的作用。我们培训计划的一个主要特点是包括10个具有更多临床、科学和/或教育专业知识的合作教员，这将极大地改善我们的培训环境，相反，他们将通过发展指导技能从参与计划中受益。我们的计划将使学员能够将遗传学、基因组学、内分泌学、新陈代谢、药理学、神经生物学、肺病学、认知神经科学、老年学和时间生物学领域的尖端方法和技术整合到他们的睡眠和昼夜研究培训中。由于本培训计划中的讲师积极参与分子、细胞、系统、行为和流行病学层面的研究，受训人员将在丰富的活动环境中接受培训，这些活动结合在一起，研究所有生物组织水平上的睡眠和昼夜功能的基本机制。

DESCRIPTION (provided by applicant): This is a resubmission of a renewal application for continued support of an established T32 Training Grant in Circadian and Sleep Research to train and support predoctoral and postdoctoral students at Northwestern University (NU) and the University of Chicago (U of C). The integration of circadian biology and sleep research in both animal models and humans has been the cornerstone of the relationship between the preceptors on this Training Grant at the U of C and NU for over 20 years, and we have added the term "circadian" to the title of our Training Program in recognition of the importance of combining these fields in the training of the next generation of young investigators. This Training Program will be led by two established senior investigators under the Multiple Leadership Plan and will involve 13 Primary Training Faculty who have their primary appointments in either basic science or clinical departments. The proposed Training Program will offer predoctoral and postdoctoral students interdisciplinary and multidisciplinary training in a wide range of scientifi disciplines that are highly relevant to understanding the function, regulation and health implications of sleep and circadian rhythmicity. Central to this Program is the training of student in modern basic science, translational research as well as patient oriented research. Multiple research perspectives have fueled for more than a decade the productive interactions and cross-fertilization that have developed between the preceptors in this Program. During the current grant period, the scope of the research activities of the Training Faculty has expanded to include bench to bedside investigations of the impact of sleep-disordered breathing on metabolism and cardiovascular function and we propose to further broaden the program in our renewed program with the addition of six outstanding physician-scientists to the training faculty. As our nation is facing unprecedented epidemics of obesity, diabetes and their cardiovascular consequences, the Training Program proposed in the present application is uniquely positioned to train an interdisciplinary workforce of academic and industry investigators as well as government decision makers to address the roles of sleep disturbances and circadian dysfunction in these public health challenges. A key feature of our Training Program is the inclusion of 10 Collaborating Faculty with additional clinical, scientific and/or educational expertise that greatly enhances our training environment, and conversely, they will benefit from their participation in the program by developing mentoring skills. Our Program will enable trainees to integrate cutting edge approaches and techniques in the areas of genetics, genomics, endocrinology, metabolism, pharmacology, neurobiology, pulmonology, cognitive neuroscience, gerontology and chronobiology into their training in sleep and circadian research. Because the preceptors in this Training Program are actively involved in research at the molecular, cellular, systems, behavioral and epidemiological levels, trainees will be trained in a rich environment of activities that are integrated together for the study of the basic mechanisms of sleep and circadian function at all levels of biological organization.