Training Grant in Circadian and Sleep Research

描述（由申请人提供）：这是一个更新申请的重新提交，以继续支持在昼夜节律和睡眠研究中建立的T32培训补助金，以培训和支持西北大学（NU）和芝加哥大学（C）的博士前和博士后学生。昼夜节律生物学和睡眠研究在动物模型和人类的整合一直是在C和NU的U这个培训补助金的导师之间的关系的基石20多年来，我们已经添加了术语“昼夜节律”到我们的培训计划的标题，认识到结合这些领域的重要性下一代年轻研究人员的培训。本次培训 该计划将由两名资深研究人员根据多重领导计划领导，并将涉及13名主要培训教师，他们主要在基础科学或临床部门任职。拟议的培训计划将为博士前和博士后学生提供广泛的科学学科的跨学科和多学科培训，这些学科与理解睡眠和昼夜节律的功能，调节和健康影响高度相关。该计划的核心是培养学生现代基础科学，转化研究以及以患者为导向的研究。十多年来，多个研究视角推动了该计划中导师之间的富有成效的互动和交叉施肥。在目前的补助金期间，培训学院的研究活动范围已扩大到包括睡眠呼吸障碍对新陈代谢和心血管功能的影响的床旁调查，我们建议在我们的更新计划中进一步扩大该计划，增加六名杰出的医生科学家到培训学院。由于我们的国家正面临着肥胖症、糖尿病及其心血管后果的前所未有的流行，本申请中提出的培训计划被独特地定位为培训学术和行业调查人员以及政府决策者的跨学科劳动力，以解决睡眠障碍和昼夜节律功能障碍在这些公共卫生挑战中的作用。我们的培训计划的一个主要特点是包括10个合作教师与额外的临床，科学和/或教育专业知识，大大提高了我们的培训环境，相反，他们将受益于他们参与该计划通过发展辅导技能。我们的计划将使学员能够将遗传学，基因组学，内分泌学，代谢，药理学，神经生物学，肺病学，认知神经科学，老年学和时间生物学等领域的尖端方法和技术整合到他们的睡眠和昼夜节律研究培训中。由于该培训计划的导师积极参与分子，细胞，系统，行为和流行病学水平的研究，因此学员将在一个丰富的活动环境中接受培训，这些活动被整合在一起，用于研究睡眠和生物组织各级昼夜节律功能的基本机制。

DESCRIPTION (provided by applicant): This is a resubmission of a renewal application for continued support of an established T32 Training Grant in Circadian and Sleep Research to train and support predoctoral and postdoctoral students at Northwestern University (NU) and the University of Chicago (U of C). The integration of circadian biology and sleep research in both animal models and humans has been the cornerstone of the relationship between the preceptors on this Training Grant at the U of C and NU for over 20 years, and we have added the term "circadian" to the title of our Training Program in recognition of the importance of combining these fields in the training of the next generation of young investigators. This Training Program will be led by two established senior investigators under the Multiple Leadership Plan and will involve 13 Primary Training Faculty who have their primary appointments in either basic science or clinical departments. The proposed Training Program will offer predoctoral and postdoctoral students interdisciplinary and multidisciplinary training in a wide range of scientifi disciplines that are highly relevant to understanding the function, regulation and health implications of sleep and circadian rhythmicity. Central to this Program is the training of student in modern basic science, translational research as well as patient oriented research. Multiple research perspectives have fueled for more than a decade the productive interactions and cross-fertilization that have developed between the preceptors in this Program. During the current grant period, the scope of the research activities of the Training Faculty has expanded to include bench to bedside investigations of the impact of sleep-disordered breathing on metabolism and cardiovascular function and we propose to further broaden the program in our renewed program with the addition of six outstanding physician-scientists to the training faculty. As our nation is facing unprecedented epidemics of obesity, diabetes and their cardiovascular consequences, the Training Program proposed in the present application is uniquely positioned to train an interdisciplinary workforce of academic and industry investigators as well as government decision makers to address the roles of sleep disturbances and circadian dysfunction in these public health challenges. A key feature of our Training Program is the inclusion of 10 Collaborating Faculty with additional clinical, scientific and/or educational expertise that greatly enhances our training environment, and conversely, they will benefit from their participation in the program by developing mentoring skills. Our Program will enable trainees to integrate cutting edge approaches and techniques in the areas of genetics, genomics, endocrinology, metabolism, pharmacology, neurobiology, pulmonology, cognitive neuroscience, gerontology and chronobiology into their training in sleep and circadian research. Because the preceptors in this Training Program are actively involved in research at the molecular, cellular, systems, behavioral and epidemiological levels, trainees will be trained in a rich environment of activities that are integrated together for the study of the basic mechanisms of sleep and circadian function at all levels of biological organization.