DEVELOPMENT OF HIV NON-VACCINE BIOMEDICAL PREVENTION PRODUCTS: PRODUCT ATTRIBUTES, POSITIONING, AND MESSAGING TO DRIVE ADOPTION AND USE OF NEW PERSONAL USE PRODUCTS

HIV 非疫苗生物医学预防产品的开发：产品属性、定位和信息传递，以推动新个人使用产品的采用和使用

• 批准号: 9545118
• 负责人: GLEN SWARTZ
• 金额: $ 49.81万
• 依托单位: ADVANCED BIOSCIENCE LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9545118
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Adoption; Clinical Trials; Contracts; Development; Devices; HIV; HIV Infections; Investigation; Investigational Drugs; Licensure; National Institute of Allergy and Infectious Disease; Pathway interactions; Play; Positioning Attribute; Prevention; Prevention strategy; Preventive vaccine; Resources; Role; Services; South African; Technology; United States Food and Drug Administration; United States National Institutes of Health; Woman; Work; microbicide; novel therapeutics; peri-urban; pre-clinical; pre-exposure prophylaxis; prevent; product development; research clinical testing; sexual HIV transmission

Comprehensive Resources for HIV Microbicides and Biomedical Prevention: The development of highly effective HIV prevention strategies, including a preventive vaccine and other non-vaccine biomedical prevention (nBP) products, remains one of the highest priorities for the Division of AIDS (DAIDS) and the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH). With current global HIV infection estimates exceeding 33 million people, the development of safe, effective, and acceptable nBP products to prevent the sexual transmission of HIV could play a major role in the worldwide reduction of the estimated 5000 new HIV infections per day. As promising nBP products emerge (e.g., microbicides, pre-exposure prophylaxis (PrEP) agents, and Multipurpose Prevention Technologies (MPT’s), there is a critical need to rapidly and efficiently move these candidates into clinical testing. The scope of work encompasses preclinical activities that range from initial product discovery to those required to support clinical trials and/or product licensure.

艾滋病毒杀菌剂和生物医学预防的综合资源：制定高效的艾滋病毒预防战略，包括预防性疫苗和其他非疫苗生物医学预防产品，仍然是美国国立卫生研究院（NIH）艾滋病司和国家过敏和传染病研究所的最高优先事项之一。目前全球艾滋病毒感染人数估计超过3300万人，开发安全、有效和可接受的nBP产品来预防艾滋病毒的性传播，可能在全球每天减少约5000例新发艾滋病毒感染方面发挥重要作用。随着有前景的nBP产品（如杀微生物剂、暴露前预防（PrEP）剂和多用途预防技术（MPT））的出现，迫切需要快速有效地将这些候选产品推向临床试验。工作范围包括临床前活动，从最初的产品发现到支持临床试验和/或产品许可所需的活动。