Head and Neck Cancer SPORE at the University of Wisconsin

项目总结 威斯康星州的头颈部孢子旨在促进实验室和临床研究的转化 改善头颈癌(HNC)患者的整体预后。这项高度合作的研究 将基础科学家与HNC临床医生联系起来，为这种复杂的癌症提出新的治疗策略 流行。根据关键的解剖结构，这些患者从他们的癌症中承受了不成比例的负担 疾病的部位，治疗可能损害说话、吞咽和呼吸功能。 到在外表和社交能力上产生重大变化。努力改进 治愈率必须与降低治疗发病率的努力仔细平衡，以提高总体 患者的生活质量。该分会的广泛目标是：1)促进多学科翻译 HNC的研究，2)改善HNC患者的总体生存和生活质量，3)开发新的动物 HNC的模型系统，以测试新的靶向治疗策略；4)开发通用资源(如 患者来源的肿瘤异种移植)将在各机构之间共享，以促进转化性研究，以及5) 将威斯康星大学开发的有前途的新分子转化为临床前和临床 测试。威斯康星州的HN孢子设计了四个主要的研究项目。项目1将定义和 使用新的小鼠模型系统靶向驱动HNC的分子通路，并确定 对临床研究的预后价值。项目2将研究一种新型的、具有肿瘤选择性的放射性标记分子 在威斯康星大学开发，通过辐射在体内针对HN肿瘤，并显示出降低以下物质毒性的潜力 常规治疗。项目3研究新的Synstatin多肽对HNC的分子靶向作用 干扰与受体酪氨酸激酶偶联的信号复合体的治疗。项目4调查 受体酪氨酸激酶Axl在HNC治疗反应和耐药性中的作用以帮助设计更有效的药物 未来的治疗策略。威斯康星州孢子将通过三个核心(管理、 病理学和生物统计学)、职业提升计划和发展研究计划。

PROJECT SUMMARY The Wisconsin Head and Neck SPORE is designed to promote translational laboratory and clinical research to improve overall outcome for patients with Head and Neck Cancer (HNC). This highly collaborative research links basic scientists with HNC clinicians to advance novel treatment strategies for this complex cancer popoulation. These patients bear a disproportionate burden from their cancers based on the critical anatomic location of the disease where treatment can compromise speech, swallow, and breathing function, in addition to creating significant alterations in physical appearance and capacity for social interaction. Efforts to improve cure rates must be carefully balanced with efforts to reduce treatment morbidity to enable enhanced overall quality of life for patients. The broad objectives of this SPORE are to: 1) Promote multidisciplinary translational research in HNC, 2) Improve overall survival and quality of life for patients with HNC, 3) Develop new animal model systems of HNC to test novel targeted therapy strategies, 4) Develop common resources (such as patient-derived tumor xenografts) to be shared across institutions to promote translational research, and 5) Translate promising new molecules developed at the University of Wisconsin through preclinical and clinical testing. The Wisconsin HN SPORE has designed four primary research projects. Project 1 will define and target molecular pathways that drive HNC using new mouse model systems, and identify biomarkers of prognostic value for clinical investigation. Project 2 will examine a novel, tumor-selective radiolabeled molecule developed at UW that internally targets HN tumors with radiation and shows potential to reduce toxicity from conventional treatment. Project 3 investigates molecular targeting of HNC with novel synstatin peptide therapeutics that disrupt signaling complexes coupled to receptor tyrosine kinases. Project 4 investigates the role of the receptor tyrosine kinase AXL in HNC therapy response and resistance to help design more effective future treatment strategies. The Wisconsin SPORE will support this research with three Cores (Administrative, Pathology and Biostatistics), a Career Enhancement Program and a Developmental Research Program.