PREDOCTORAL AND POSTDOCTORAL TRAINING PROGRAM IN AGING AND DEMENTIA

摘要 该提案要求继续资助基础广泛的博士前和博士后机制。 西北大学跨部门神经科学的衰老和痴呆症培训计划 方案（NUIN）。资助四名高级博士预科生，在他们开始全职工作后 需要进行论文研究，并需要4名处于早期或后期培训阶段的博士后学员。培训 为期两年，目的是协助受训人员提交报告并获得个人的支持。 在培训补助金支助之后提供研究金。该培训计划从多学科发展而来， 一组研究人员，他们的工作重点是衰老和痴呆症的机制，包括阿尔茨海默氏症 疾病，帕金森病和肌萎缩侧索硬化症，与方法跨越分子， 细胞、系统、行为、神经心理学和临床神经科学。这些教师是附属于 主要是与NUIN和认知神经学和阿尔茨海默病中心合作，该中心有一个NIA支持 阿尔茨海默病中心赠款，和尤德尔帕金森病中心。该计划将由 John Disterhoft博士和Robert Vassar博士以Multi-PI格式指导该计划， 资金年16-17，博士Disterhoft和瓦萨共同指导该计划在资金年18-19，博士。 瓦萨在第20年资助该项目。他们将得到桑德拉温特劳布博士的帮助 （副主任），一个内部指导委员会和一个外部咨询委员会。四 博士预科生和四名博士后学员将在36名导师的指导下进行研究， 西北大学芝加哥和埃文斯顿校区的3所学校的13个系，以及一个 来自拉什大学医学院博士前学员将从NUIN和其他选择 参与博士课程的基础上的表现，研究轮换评估，和 提出的论文研究的相关性。博士后培训生将在以往的基础上选择 培训和研究计划。对于研究计划符合以下条件的学员，将给予特别考虑： 跨学科，并在一个以上的导师实验室进行。将作出一致努力， 从代表性不足的背景中招募受训人员。该计划将提供广泛的跨学科 研究和培训机会，在基础和临床方法，以老化和痴呆症 research.导师将通过正式的建议和指导来帮助和监督学员的进步， 通过课堂和非正式讨论进行评估。除了提供研究培训外， 该计划将帮助学员发展书面和口头沟通，赠款写作，网络， 职业发展和确保研究结果的可重复性和准确性的技术。灌输 对神经科学家面临的伦理问题和科学中负责任的行为的清晰认识将是另一个 训练目标。

Abstract This proposal is a request for continued funding of a broadly based predoctoral and postdoctoral Mechanisms of Aging and Dementia Training Program from the Northwestern University Interdepartmental Neuroscience Program (NUIN). Funding to support four advanced predoctoral candidates, after they have begun full-time thesis research, and four postdoctoral trainees in early or later stages of training, is requested. Training duration will be for two years with a goal to assist trainees in submitting and obtaining support from individual research fellowships following training grant support. This training program developed from a multidisciplinary group of investigators whose work focuses on the mechanisms of aging and dementia, including Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis, with approaches spanning molecular, cellular, systems, behavioral, neuropsychological and clinical neuroscience. These faculty are affiliated primarily with NUIN and the Cognitive Neurology and Alzheimer's Disease Center, which has an NIA supported Alzheimer's Disease Center grant, and the Udall Parkinson's Disease Center. The program will be directed by John Disterhoft, PhD and Robert Vassar, PhD in a Multi-PI format, with Dr. Disterhoft directing the program in funding years 16-17, Drs. Disterhoft and Vassar jointly directing the program in funding years 18-19, and Dr. Vassar directing the program in funding year 20. They will have the assistance of Sandra Weintraub, PhD (Associate Director), an internal Steering Committee and an External Advisory Committee. The four predoctoral and four postdoctoral trainees will conduct their research under the guidance of 36 preceptors from 13 departments of 3 schools on the Chicago and Evanston campuses of Northwestern University, and one from Rush University Medical School. Predoctoral trainees will be selected from NUIN and the other participating PhD programs on the basis of course performance, research rotation evaluations, and the relevance of proposed dissertation research. Postdoctoral trainees will be selected on the basis of previous training and a research plan. Special consideration will be given to trainees whose research plans are interdisciplinary and carried out in more than one preceptor laboratory. A concerted effort will be made to recruit trainees from underrepresented backgrounds. The program will offer a broad range of interdisciplinary research and training opportunities in both the fundamental and clinical approaches to aging and dementia research. The preceptor faculty will assist and monitor trainee progress through formal advising and evaluations, through the classroom and through informal discussions. In addition to providing research training, the program will help trainees develop skills in written and oral communication, grant writing, networking, career development and techniques for insuring reproducibility and accuracy of research findings. Instilling a clear awareness of ethical issues facing neuroscientists and responsible conduct in science will be another training goal.