Multiplexing biomarker analyzer

 描述(由申请人提供)：本申请请求支持购买Luminex 100/200，这是一种利用基于微珠的检测技术分析900多种单个分析物的实验样本(裂解产物、血清、组织)的系统。Luminex 100/200仪器使研究人员能够对蛋白质或核酸生物标志物进行多路分析和小型化，从而提高数据质量、吞吐量和成本效益。集中这些研究并提供各种分析物的最先进的高通量分析的机会将最大限度地减少成本和时间，同时最大化产量。在本申请中详述的9个NIH资助的实验室的具体项目在科学兴趣上存在很大差异，但它们都有一个共同的目标，即在患者样本或疾病实验室模型的背景下寻求翻译终点。

 DESCRIPTION (provided by applicant): This application requests support for the purchase of a Luminex 100/200, a system that analyzes experimental samples (lysates, serum, tissues) for over 900 individual analytes utilizing a bead-based detection technology. The Luminex 100/200 instrument allows investigators to multiplex and miniaturize assays of either protein or nucleic acid biomarkers increasing data quality, throughput and cost effectiveness. The opportunity to centralize these studies and provide state-of-the-art high-throughput assays of a variety of analytes will minimize cost and time, while maximizing output. The specific projects of the 9 NIH funded laboratories detailed within this application vary widely in their scientific interests, however they share the common goal of pursuing translational endpoints within the context of patient samples or laboratory models of disease.