Visuomotor integration and attention in Autism Spectrum Disorder

自闭症谱系障碍的视觉运动整合和注意力

• 批准号: 9314958
• 负责人: Haylie L Miller
• 金额: $ 18.84万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-12 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9314958
• 关键词: Activities of Daily Living; Adolescent; Adult; Advisory Committees; Affect; Age; Attention; Attentional deficit; Automobile Driving; Behavior; Behavioral Symptoms; Biometry; Caregivers; Child; Clinical; Cognitive; Complex; Consultations; Data; Detection; Development; Disease; Educational workshop; Environment; Eye; Eye Movements; Failure; Funding; Gender; Head; Head Movements; Human; Impairment; Individual; Individual Differences; Intercept; Intervention; Investigation; Knowledge; Light; Mentors; Motion; Motion Perception; Motor; Movement; Musculoskeletal Equilibrium; Neurosciences; Outcome Measure; Performance; Persons; Physical Fitness; Play; Positioning Attribute; Process; Publications; Recruitment Activity; Research; Research Activity; Resources; Role; Saccades; Sensory; Series; Social Interaction; Social isolation; Speed; Sports; Stimulus; Symptoms; System; Task Performances; Taxes; Time; Training; Training Activity; Visual; Visual Motion; Visual Perception; Visual attention; attentional control; autism spectrum disorder; biomechanical model; body position; boys; cognitive load; experience; functional disability; improved; innovation; mathematical model; motor control; motor deficit; object motion; programs; relating to nervous system; response; scaffold; sedentary lifestyle; skills; social; stem; virtual; virtual reality; visual information; visual motor; visual tracking

PROJECT SUMMARY The candidate, Dr. Haylie Miller, aims to develop a program of research on visuomotor integration in Autism Spectrum Disorder (ASD). She and her mentors (Drs. Nicoleta Bugnariu, Mary Hayhoe, and Matt Mosconi), have planned a series of training and research activities, including workshops, formal coursework, and consultation with experts in the fields of ASD, developmental neuroscience, motor control, and eye tracking. Dr. Bugnariu and Dr. Hayhoe are co-primary mentors: Dr. Bugnariu has expertise in motor control, developmental neuroscience, and functional movement in ASD; Dr. Hayhoe has expertise in visuomotor integration and eye movement in typical development, as well as a prolific record of publication and federal funding. Dr. Mosconi, a recognized expert in motor development in ASD, will serve as a secondary mentor. An advisory team will also support Dr. Miller's training: Drs. Garver and Dempsey have ample experience working with individuals across the widely variable symptom profile of the disorder. Dr. Rita Patterson is an expert in biomechanics and mathematical modeling of time series data; Dr. Linda Hynan is an expert in biostatistics. Dr. Miller will study visuomotor integration–the process of using visual information to plan, execute, and modify movements–in 45 children with ASD (ages 7-17) and 45 age-, gender- and IQ-matched typically- developing (TD) controls. Accurate visuomotor integration is critical for interacting with the environment. Despite prior studies of motion perception, it is still unclear whether individuals with ASD fail to appropriately interact with moving objects because they do not accurately: i) direct visual attention to objects; ii) assess the spatial position and motion of objects; iii) use visual information to plan a motor response; and/or iv) execute motor plans to achieve desired body movements. The proposed study will quantify differences between TD and ASD in the ability to perceive object motion, and execute/modify planned motor responses. To accomplish this aim, Dr. Miller will use a unique combination of mobile eye-tracking, motion capture, and virtual reality to assess response to visual motion. Variable speeds, distractor objects and complex background settings will be used in interactive virtual games to assess the role of attention in processing and reacting to motion. By studying visuomotor integration in the virtual environment, which more closely mirrors real-world cognitive and visual demands, Dr. Miller aims to understand the practical consequences of this deficit in ASD. Clinical symptoms (e.g., clumsiness) and functional impairments (e.g., driving, playing sports) in ASD likely stem from ineffective visuomotor integration. Particularly for adolescents, the transition to adulthood and independence is accompanied by a number of visuomotor challenges like driving, sports and physical fitness, and social interaction. Failure to master these skills can result in added burden on caregivers, sedentary lifestyle, and social isolation. Knowledge generated by the proposed project may aid in identifying targets for intervention to remediate these symptoms and restore functional ability in people with ASD.

项目概要 候选人 Haylie Miller 博士旨在开发一项关于视觉运动整合的研究计划 自闭症谱系障碍 (ASD)。她和她的导师（Nicoleta Bugnariu 博士、Mary Hayhoe 和 Matt Mosconi）计划了一系列培训和研究活动，包括研讨会、正式课程、 并咨询 ASD、发育神经科学、运动控制和眼科领域的专家 追踪。 Bugnariu 博士和 Hayhoe 博士是共同主要导师：Bugnariu 博士拥有电机控制、 发育神经科学和自闭症谱系障碍的功能运动； Hayhoe 博士拥有视觉运动方面的专业知识 典型发展中的整合和眼动，以及出版和联邦的丰富记录 资金。 Mosconi 博士是自闭症谱系障碍 (ASD) 运动发育领域公认的专家，他将担任第二导师。一个 顾问团队还将支持米勒博士的培训：博士。加弗和登普西拥有丰富的工作经验 该疾病的症状特征差异很大。丽塔·帕特森博士是以下领域的专家 时间序列数据的生物力学和数学建模； Linda Hynan 博士是生物统计学专家。 米勒博士将研究视觉运动整合——使用视觉信息来计划、执行、 并改变动作——45 名自闭症谱系障碍儿童（7-17 岁）和 45 名年龄、性别和智商通常匹配的儿童—— 开发（TD）控制。准确的视觉运动整合对于与环境互动至关重要。 尽管之前对运动知觉进行了研究，但仍不清楚自闭症谱系障碍患者是否未能适当地 与移动物体进行交互，因为它们不能准确地： i) 将视觉注意力引导到物体上； ii) 评估 物体的空间位置和运动； iii) 使用视觉信息来计划运动反应；和/或 iv) 执行 运动计划以实现所需的身体运动。拟议的研究将量化 TD 之间的差异 自闭症谱系障碍（ASD）是指感知物体运动并执行/修改计划的运动反应的能力。为了完成 为了实现这一目标，米勒博士将使用移动眼动追踪、动作捕捉和虚拟现实的独特组合来 评估对视觉运动的反应。可变速度、干扰物体和复杂的背景设置将 用于交互式虚拟游戏中，以评估注意力在处理运动和对运动做出反应时的作用。 通过研究虚拟环境中的视觉运动整合，更接近地反映现实世界 为了满足认知和视觉需求，米勒博士旨在了解自闭症谱系障碍中这种缺陷的实际后果。 自闭症谱系障碍 (ASD) 可能出现临床症状（例如笨拙）和功能障碍（例如驾驶、运动） 源于无效的视觉运动整合。特别是对于青少年来说，在向成年的过渡和 独立伴随着许多视觉运动挑战，如驾驶、运动和身体健康， 和社交互动。未能掌握这些技能可能会给护理人员、久坐的人带来额外的负担 生活方式和社会隔离。拟议项目产生的知识可能有助于确定目标 干预措施以纠正自闭症谱系障碍患者的这些症状并恢复功能能力。