Neurobiology of Reward Choice

奖励选择的神经生物学

基本信息

批准号：
9304986
负责人：
DAVID WEINSHENKER
金额：
$ 19.5万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9304986
关键词：
Abstinence Animal Model Attenuated Back Behavior Behavior Control Behavior Therapy Behavioral Brain Chronic Clinical Cocaine Cocaine Abuse Cocaine Dependence Cues Development Dopamine Drug Addiction Drug Exposure Drug Modelings Drug abuse Drug usage Electrodes Exhibits Exposure to Extinction (Psychology)FDA approved Female Food Goals Implant Investigation Lead Learning Measures Methods Modeling Motivation Neuroanatomy Neurobiology Neurotransmitters Nucleus Accumbens Periodicity Pharmaceutical Preparations Pharmacotherapy Play Prize Procedures Public Health Rattus Relapse Research Personnel Research Project Grants Rewards Role Scanning Sex Characteristics Signal Transduction Stimulus Sucrose System Testing Therapeutic Time Training United States Variant Visual Water Women&apos s Group base carbon fiber contingency management drug of abuse effective therapy hedonic incentive salience male men&apos s group neurochemistry neurotransmission non-drug novel preference prevent reinforcer response sex stressor transmission process treatment program

项目摘要

Project Summary/Abstract Cocaine abuse has persisted as a major public health concern within the United States for several decades despite substantial efforts to develop therapeutic strategies for its treatment. In particular, medications development efforts have failed to yield a single FDA-approved or generally accepted pharmacotherapy for cocaine dependence. Prominent and problematic consequences of prolonged drug abuse include the persistent devaluation of natural nondrug rewards that previously functioned as effective reinforcers prior to drug exposure, and an increase in the “incentive salience” of drug-associated stimuli, leading to the model that drugs “hijack” the brain's natural reward system. The purpose of this proposal is to determine whether a behavioral modification strategy encompassing occasional, unexpected presentation of a high-value, alternate reinforcer will increase the hedonic value and/or motivational salience of a natural reward such that it will reduce cocaine seeking in rats. In Aim 1, we will use an operant cocaine vs. food choice procedure to determine whether a rare, unexpected reward will shift preferred responding from cocaine to food and alter associated dopamine transmission in the nucleus accumbens. Aim 2 will examine the consequences of this behavioral manipulation in a model of relapse-like behavior.

项目摘要/摘要几十年来，美国滥用可卡因一直是美国的主要公共卫生问题尽管为制定理论策略的治疗而做出了巨大努力。特别是药物开发工作未能产生单一的FDA批准或公认的药物治疗可卡因依赖性。长期滥用药物的突出和有问题的后果包括持久性天然非拉力奖励的贬值，该奖励以前在药物之前用作有效增强剂暴露，以及与药物相关刺激的“激励显着性”的增加，导致该模型的吸毒 “劫持”大脑的自然奖励系统。该提案的目的是确定行为是否修改策略包括偶尔出现的高价值，替代增强剂的意外表示将增加自然奖励的享乐价值和/或动机显着性，从而减少可卡因寻找老鼠。在AIM 1中，我们将使用可卡因和食物选择程序来确定罕见的意外的奖励将转变从可卡因到食物的偏爱回应，并改变相关的多巴胺伏隔核的传播。 AIM 2将检查这种行为操纵的后果在类似浮雕的行为模型中。