IGF::OT::IGF FRAMINGHAM HEART STUDY (FHS) - TASK ORDER 01

IGF::OT::IGF 弗雷明汉心脏研究 (FHS) - 任务单 01

• 批准号: 9462599
• 负责人: VASAN RAMACHANDRAN
• 金额: $ 473.06万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-18 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9462599
• 关键词: Abdomen; African American; Age; American Indians; Area; Asians; Atherosclerosis; Behavior; Biochemical; Bioinformatics; Biological Markers; Blood; Boston; Bronchodilator Agents; Calcified; Calcium; Cell Line; Clinical; Coagulation Process; Communities; Complement; Complex; Contracts; Coronary; DNA; DNA Resequencing; Data; Development; Disease; Environment; Environmental Risk Factor; Family; Fatty acid glycerol esters; Framingham Heart Study; Funding; Generations; Genes; Genetic; Genetic study; Genome; Genotype; Grant; Heart; Hispanics; Hormonal; Imaging Techniques; Insulin Resistance; Knowledge; Laboratories; Lipids; Lipoproteins; Longitudinal cohort study; Lung; Measurement; Measures; Minority; Obesity; Participant; Persons; Phenotype; Physical Function; Physical activity; Privacy; Process; Recruitment Activity; Renal function; Research Personnel; Resources; Rest; Risk Factors; Scanning; Sleep; Spirometry; Structure of parenchyma of lung; Techniques; Time; United States National Institutes of Health; Universities; Visceral; X-Ray Computed Tomography; adipokines; base; calcification; cognitive function; cohort; detector; follow-up; genetic analysis; immortalized cell; inflammatory marker; innovation; offspring; phenotypic data; pulmonary function

The Framingham Heart Study is a longitudinal cohort study that began in 1948 and continues to this day. The objectives for the Framingham Heart Study are to significantly expand knowledge about the complex influences of genes and environment on development and progression of heart, lung, blood and sleep (HLBS) diseases and disorders, by utilizing the extensive array of new and existing information on genetics, behaviors, biomarkers, imaging techniques, and environmental factors. This objective is accomplished through re-examination of each of the three Framingham cohorts (Original, Offspring, Generation III) for measurement of complex phenotypes; through rapid distribution of DNA for extensive and focused genotyping; for rapid distribution of genetic and phenotypic measurements for use by investigators internal and external to the Framingham Study; and through analyses of the contribution of genes, new and established risk factors, and innovative biomarkers to the development and progression of subclinical and clinical disease. Starting in late 2009, the Framingham Omni cohorts will be integrated into the contract for the Framingham Heart Study. The Omni cohort participants, consisting of minority residents of Framingham, MA, were recruited by Framingham Heart Study investigators in 1994-1995 (Omni Cohort 1) and 2003-2005 (Omni Cohort 2) to complement the study and reflect the growing diversity of that community. The Omni cohorts consisted of Hispanics, African Americans, Asians, and a few American Indians. Three examinations and one examination were conducted on the Omni Cohort 1 and Omni Cohort 2, respectively, with funding provided through NIH grants to Boston University. By integrating the Omni cohort into the Framingham Heart Study contract, the Omni cohorts will consistently receive the same surveillance and examination as the rest of the Framingham Heart Study participants. The integration of the Omni cohort will make the study findings more applicable to the community.

心脏病研究是一项纵向队列研究，始于1948年，一直持续到今天。Frachial Heart研究的目标是通过利用广泛的关于遗传学，行为，生物标志物，成像技术和环境因素的新的和现有的信息，显着扩展有关基因和环境对心脏，肺，血液和睡眠（HLBS）疾病和障碍的发展和进展的复杂影响的知识。这一目标是通过重新审查三个FRADIONAL群组中的每一个来实现的（原始、后代、第三代）用于测量复杂表型;通过快速分发DNA进行广泛和集中的基因分型;用于快速分发遗传和表型测量结果，供Fracket研究内部和外部的研究者使用;并通过分析基因、新的和已建立的风险因素以及创新的生物标志物对亚临床和临床疾病的发展和进展的贡献。从2009年年底开始，Frachial Omni队列将被纳入Frachial Heart研究的合同。Omni队列参与者由马萨诸塞州Fracket的少数民族居民组成，由Fracket心脏研究研究人员在1994-1995年（Omni队列1）和2003-2005年（Omni队列2）招募，以补充研究并反映该社区日益增长的多样性。全方位的队列包括西班牙裔，非洲裔美国人，亚洲人和一些美洲印第安人。分别对Omni队列1和Omni队列2进行了三次检查和一次检查，资金通过NIH向波士顿大学提供。通过将Omni队列整合到弗雷明汉心脏研究合同中，Omni队列将始终接受与弗雷明汉心脏研究其他参与者相同的监测和检查。全方位队列的整合将使研究结果更适用于社区。