Epidemiology, Clinical Trials and Outcomes Research In Nephrology

肾脏病学的流行病学、临床试验和结果研究

• 批准号: 9294026
• 负责人: ANDREW S LEVEY
• 金额: $ 17.05万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-20 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9294026
• 关键词: Clinical Trials; Epidemiology; Nephrology; Outcomes Research

 DESCRIPTION (provided by applicant): Chronic kidney disease (CKD) and acute kidney injury (AKI) are public health problems in the US. Reports from the National Institutes of Health, Institute of Medicine and Patient Centered Outcomes Research Institute recommend strengthening training programs for physicians in the methods of clinical research to translate advances in basic science to improvements in health. This application is to renew the training program in "Epidemiology, Clinical Trials and Outcomes Research" established sixteen years ago within the William B. Schwartz Division of Nephrology at Tufts Medical Center and Tufts University School of Medicine. Andrew S. Levey, MD and Mark J. Sarnak, MD, MS remain the Program Director and Associate Program Director, respectively. The proposed training program is unique in that it combines training by nephrologists with outstanding records in cutting-edge clinical research and by established scientists in epidemiology, biostatistics and health services research. Faculty supervision is complemented by oversight by internal and external advisors, including senior clinical investigators and world leaders in public health related to CKD and AKI. Specific aims 1 and 2 are unchanged but their execution has been substantially strengthened by growth and maturation of research in the Division of Nephrology and integration with the Tufts Clinical and Translational Sciences Institute (CTSI), funded by the NIH: 1) Didactic Training - course work in fulfillment of the MS degree in the Graduate Program in Clinical Research at the Sackler School of Graduate Biomedical Sciences at Tufts University, with 3 areas of concentration. 2) Independent Study - an hypothesis-based research project supervised by a nephrologist mentor and a research team of faculty with expertise in other disciplines. Nephrology faculty and their collaborators have databases and ongoing studies that can serve as the subject of the trainees' research projects. Specific Aim 3 is now more focused on Career Development - to prepare trainees to serve as leaders in academic medicine, government and industry. Integration of all aspects of the curriculum with trainees' research projects is ensured by the nephrologist mentors. Mentor training will be implemented in 2016 in association with the CTSI. All 15 approved trainee positions in the past 5 years have been filled. An additional 13 trainee positions have been supported by other sources during this time. Of the 56 trainees who have completed the program since its inception, 37 took first positions in academic medicine, 5 in industry or government, and 14 in clinical practice. Twenty-three have received grant support. There were 42 applicants for 2014 and 35 for 2015. In view of the declining number of applicants to nephrology programs nationwide, renewal of 2 training positions per year is requested for the next 5 years.

 描述（由申请人提供）：慢性肾脏疾病（CKD）和急性肾损伤（阿基）是美国的公共卫生问题。美国国立卫生研究院、医学研究所和以患者为中心的结果研究所的报告建议加强对医生的临床研究方法培训计划，以将基础科学的进步转化为健康的改善。本申请旨在更新十六年前在威廉B内建立的“流行病学、临床试验和结果研究”培训计划。塔夫茨医学中心和塔夫茨大学医学院的Schwartz肾脏病学分部。Andrew S. Levey，MD和Mark J. Sarnak，MD，MS分别担任项目总监和副项目总监。拟议的培训计划是独一无二的，因为它结合了肾脏病学家在尖端临床研究和流行病学，生物统计学和卫生服务研究方面的杰出记录的培训。教师监督由内部和外部顾问监督补充，包括高级临床研究人员和与CKD和阿基相关的公共卫生领域的世界领导者。具体目标1和2保持不变，但其执行已通过肾脏科研究的增长和成熟以及与Tufts临床和转化科学研究所（CTSI）的整合而得到实质性加强，该研究所由NIH资助：1）教学培训-在塔夫茨大学萨克勒生物医学研究生院临床研究生课程中完成硕士学位的课程工作大学，有三个集中的领域。2)独立研究-一个基于假设的研究项目，由肾病学家导师和具有其他学科专业知识的教师研究团队监督。肾脏病学教师及其合作者拥有数据库和正在进行的研究，可以作为学员研究项目的主题。具体目标3现在更侧重于职业发展-准备学员担任学术医学，政府和行业的领导者。课程的各个方面与学员的研究项目的整合是由肾病学家导师确保的。将于2016年与CTSI合作开展导师培训。在过去5年中，所有15个经批准的实习生职位都已填补。在此期间，另有13个受训人员职位得到了其他来源的支助。在自成立以来完成该计划的56名学员中，37人在学术医学中担任第一职位，5人在工业或政府中担任第一职位，14人在临床实践中担任第一职位。23个项目获得了赠款支助。2014年有42名申请人，2015年有35名申请人。鉴于全国肾脏学项目的申请人数下降，要求在未来5年内每年更新2个培训职位。