IGF::OT::IGF High-plex Pharmacodynamic Biomarker Assay

IGF::OT::IGF 多重药效生物标志物测定

• 批准号: 9581565
• 负责人: RALPH PARCHMENT
• 金额: $ 2526.66万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-21 至 2022-09-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9581565
• 关键词: Affect; Algorithmic Analysis; Antibodies; Apoptosis; Biochemical; Biological Assay; Biological Markers; Biological Tumor Markers; Biopsy; Cell Death; Cell Survival; Clinical; Clinical Trials; Complex; DNA Repair; Detection; Development; Drug Evaluation; Epithelial; Functional Imaging; Histology; Human; Humor; Image Analysis; Imaging Techniques; Laboratories; Link; Measures; Medical Imaging; Meiosis; Membrane; Mesenchymal; Mismatch Repair; Modeling; Necrosis; Needles; Oxidases; Patients; Pharmaceutical Preparations; Pharmacodynamics; Reproducibility; Sampling; Stress; System; Technology; Technology Transfer; Testing; Tumor Immunity; United States National Institutes of Health; Validation; biological systems; cancer cell; design; drug development; endoplasmic reticulum stress; fitness; molecular imaging; neoplastic cell; oxidative DNA damage; pharmacodynamic biomarker; repaired; response; stemness; targeted cancer therapy; tumor

Pharmacodynamics is the drug-induced response of a biological system and it can be assessed and quantitated using molecular, physiological and medical imaging techniques. As part of DCTD’s support for targeted cancer therapies, it is necessary to develop useful and reliable assays that can guide drug development and be used to understand the biochemical changes that are part of the evaluation of drug response in clinical trial patients. This project supports the design, development, validation and demonstration of fitness-for-purpose of a new multiplex assay for the analysis and quantitation of important biological markers of tumor cell death or survival. These robust assays will be created to support testing of humor tumor biopsies collected during the conduct of human clinical trials and will investigate the linkage between ER stress, oxidative DNA damage and repair, and tumor cell death.

药效学是生物系统的药物诱导反应，它可以通过分子、生理和医学成像技术进行评估和定量。作为DCTD对靶向癌症治疗支持的一部分，有必要开发有用且可靠的检测方法，以指导药物开发，并用于了解临床试验患者药物反应评估的生化变化。该项目支持设计、开发、验证和演示一种新的多功能检测方法，用于分析和定量肿瘤细胞死亡或存活的重要生物标志物。这些强大的分析将用于支持在人体临床试验期间收集的幽默肿瘤活检的测试，并将研究内质网应激、氧化DNA损伤和修复以及肿瘤细胞死亡之间的联系。