Animal and Pathology Core

动物/病理学核心的目标是： AIM A.收集、处理、存档和分发人类和动物组织（项目1、2、3、4） AIM B。进行肿瘤切除和照明;协助其他小鼠治疗（项目2、3、4） AIM C.协助小鼠尸检（达勒姆博士），协调动物和人体肿瘤的移动 病理学（人或兽医，如相关）之间用于免疫组织化学分析的样本 以及项目负责人的实验室。 核心B的优势在于它将提供一致的动物模型、动物治疗、组织收集和 本PPG中项目的病理分析。考虑到PDT的“高科技”性质， 尤其重要。核心将作为中心点，以确保组织的收集和分发 以一致的方式，根据我们的SOP，并将使用详细的数据很好地记录此过程 核心B附录中包含的收集表格。悉尼·埃文斯博士将担任核心B的主任; 达勒姆将负责尸检后的动物相关免疫组织化学任务（目的C）。的 核心B的功能可分为动物和病理亚核心。 动物副核心将负责 1)协助PI制定、提交和维护IACUC提案 2)订购动物 3)执行项目间动物工作，包括肿瘤植入、照明、组织收集 病理学子核心将： 1)协助动物和人体组织/血液的采集、处理和存档或储存 2)监督小鼠尸检，收集和提交组织进行染色/组织病理学审查

The aims of the Animal/Pathology Core are to: AIM A. Collect, process, archive and distribute human and animal tissues (Projects 1,2,3,4) AIM B. Perform tumor implantations and illuminations; assist in other treatments of mice (Projects 2,3,4) AIM C. Assist in mouse autopsies (Dr. Durham) and coordinate the movement of animal and human tumor samples for immunohistochemical analysis between Pathology (human or veterinary, as relevant) and the laboratories of Project Leaders. The strength of Core B is that it will provide consistent animal models, animal treatments, tissue collection and pathologic analyses for the projects in this PPG. Given the “high tech” nature of delivering PDT, this is particularly important. The Core will act as a center point to assure that tissues will be collected and distributed in a consistent manner, based on our SOPS, and this process will be well documented using detailed data collection forms included in the Appendix of Core B. Dr. Sydney Evans will be the director of Core B; Dr. Durham will be responsible for the animal-related immunohistochemistry tasks after autopsy (Aim C). The functions of Core B can be separated into the ANIMAL and the PATHOLOGY subcores. The ANIMAL SUBCORE will be responsible for 1) Aiding the PIs in developing, submitting and maintaining IACUC proposals 2) Ordering animals 3) Performing inter-project animal work, including tumor implantation, illumination, tissue collection The PATHOLOGY SUBCORE will: 1) Aid in the collection, processing, and archiving or storage of animal and human tissues/blood 2) Oversee murine autopsies, collection and submission of tissues for staining/histopathological review