Caenorhabditis Genetics Center

线虫遗传中心(CGC)是唯一一个综合性的储存库和配送中心 线虫秀丽线虫，生物医学研究的主要模式生物。整体而言 该动物资源的目标是通过获取、维护和维护线虫来促进线虫的研究 分发具有遗传特征的线虫种群。世界各地的研究人员使用遗传库 从CGC获得的各种基础和应用研究工作，以及实践教学 实验科学。使用这种首屈一指的模式生物体的研究导致了对基本 生物学机制，包括细胞程序性死亡的遗传基础，microRNAs的发现，以及 动物体内RNA干扰的机制。事实证明，线虫对于理解 癌症进展和其他疾病的机制，包括阿尔茨海默氏症和帕金森氏症，以及 揭示人类发展的基本机制。此外，线虫是一种重要的 阐明我们对寄生线虫与人类和家畜健康相关的理解。作为 CGC是线虫的唯一通用库存中心，是极其重要的国际研究资源， 支持这些不同领域的研究和教育努力。CGC提供了超过30,000个 菌株每年被分发到数千个实验室；收集了超过19,000个独特的菌株，仍然 随着该领域的发展，CGC不仅促进了研究，还确保了 有价值的菌株被保存下来。CGC通过在线订购系统应要求分发菌株。 用户收费计划有助于支付成本和支持CGC活动。CGC还包括一项研究 旨在加强CGC收集的组成部分。我们对用户需求的密切监控，与C. 优雅的社区，对遗传工具的关注给了我们一个独特的视角来设计一项研究 组件。将追求两个目标，一个重点是通过开发 染色体内倒位基因用作交叉抑制基因。另一个目标是完成收集 MicroRNA基因的零突变。

The Caenorhabditis Genetics Center (CGC) is the sole comprehensive repository and distribution center for the nematode Caenorhabditis elegans, a premier model organism for biomedical research studies. The overall objective of this animal resource is to promote research on C. elegans by acquiring, maintaining, and distributing genetically characterized nematode stocks. Researchers throughout the world use genetic stocks obtained from the CGC in diverse basic and applied research endeavors, as well as for hand-on teaching of experimental science. Studies using this premier model organism have led to fundamental insights into basic biological mechanisms, including the genetic basis of programmed cell death, the discovery of microRNAs, and the mechanism of RNA interference in animals. The nematode has also proved important for understanding mechanisms of cancer progression and other diseases including Alzheimer's and Parkinson's, as well as for revealing basic mechanisms underlying human development. In addition, C. elegans serves as a key model for illuminating our understanding of parasitic nematodes with relevance to human and livestock health. As the only general stock center for C. elegans, the CGC is an extremely important international research resource, supporting research in these diverse areas and educational endeavors. The CGC provides more than 30,000 strains are distributed per year to thousands of laboratories; with a collection of over 19,000 unique strains, still expanding in proportion to the growth of the field, the CGC not only facilitates research, but also ensures that valuable strains are preserved. The CGC distributes strains upon request through an on-line ordering system. A scheme of user fees helps to defray costs and support CGC activities. The CGC also includes a research component aimed at enhancing the CGC collection. Our close monitoring of user needs, ties with the C. elegans community, and focus on genetic tools has given us a unique perspective in devising a research component. Two aims will be pursued, one focused on expanding the genetic tool-kit by generating intrachromosomal inversions for use as crossover suppressors. The other aim is to complete the collection of null mutations in microRNA genes.