Forging a road to personalized medicine in interstitial lung diseases

开辟间质性肺疾病个体化医疗之路

• 批准号: 9187992
• 负责人: KEVIN R FLAHERTY
• 金额: $ 18.18万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9187992
• 关键词: Amendment; Award; Basic Science; Biological; Biological Markers; Biometry; Biopsy; Blood; Bronchoalveolar Lavage; Cessation of life; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Computer Assisted; Computer software; Data; Data Analyses; Data Collection; Databases; Diagnosis; Diagnostic radiologic examination; Disease; Disease Progression; Dyspnea; Educational Activities; Epigenetic Process; Etiology; Evaluation; Exercise; Feedback; Fellowship; Funding; Future; Gases; Glass; Goals; Grant; Hamman-Rich syndrome; Health; High Resolution Computed Tomography; Home environment; Home visitation; Human; Hypersensitivity; Image Analysis; Individual; Institutes; Institutional Review Boards; Interstitial Lung Diseases; Knowledge; Lung; Lung diseases; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Michigan; Molecular Genetics; Outcome Measure; Patient Care; Patients; Performance; Phase; Phenotype; Physicians; Pneumonia; Protocols documentation; Publications; Pulmonary Emphysema; Quality of life; Research; Research Design; Research Personnel; Research Project Grants; Resources; Sampling; Scanning; Schedule; Source; Specimen; Structure of parenchyma of lung; Survival Analysis; Therapeutic Trials; Time; Training; Translational Research; Universities; Walking; Work; clinical investigation; database design; design; disability; experience; forging; improved; insight; longitudinal analysis; meetings; multidisciplinary; outcome forecast; outcome prediction; patient oriented research; personalized approach; personalized medicine; potential biomarker; predicting response; prospective; responsible research conduct; sildenafil; skills; statistics; symposium

DESCRIPTION (provided by applicant): The two main goals of this award are to increase my ability to serve as an effective mentor while also providing training that will allow young investigators to successfully compete for a K23 award and subsequent independent funding. A diverse platform of educational activities, ongoing research, and the potential for future studies are available to aid in the training of pulmonary physicians in patient oriented research (POR). Throughout this award I will participate in ongoing educational activities. I will improve my understanding of the basic study of pulmonary diseases through attending a weekly basic science research conference. I will take statistical courses to expand my knowledge related to analyzing longitudinal and clustered data, high throughput molecular, genetic, and epigenetic data, and advanced concepts in clinical trials and survival analysis. I will continue my training i the responsible conduct of research through institutional review board sponsored courses as well as courses from the Michigan Institute for Clinical & Health Research/Clinical & Translational Science Award (MICHR/CTSA). The basic mentoring plan for trainees includes an individualized research project in POR, scheduled mentor meetings, close collaboration with statisticians, formal educational activities targeting statistics & the responsible conduct of research, and scheduled formal feedback from a mentoring team. The UM Multidisciplinary Training Grant (T32 HL07749-18) and close collaboration with MICHR/CTSA provides funding for additional years of post-fellowship training and a Masters in Biostatistics & Clinical Study Design. A diverse portfolio of currently funded research opportunities exists for future trainees in POR. These projects offer a combination of already established databases for immediate use, raw data that can be maneuvered into databases and the ability to prospectively collect new data including patient specimens. Funded research projects are evaluating the use of computer aided image analysis software for use in clinical trials for patients with idiopathic pulmonary fibrosis, evaluation of potential biomarkers to predict the future course of patients with IPF, participation in the IPF clinical research network and the Lung Tissue Research Consortium. This application also proposes two new research projects. The first project determines the ability of high resolution computed tomography features to predict response to therapy with sildenafil for patients with advanced idiopathic pulmonary fibrosis. This study utilizes data that are available through the IPFnet. A second project will create a database and also study human samples to improve our understanding of the diagnosis, predictors of outcome, and pathobiology of hypersensitivity pneumonia.

描述(由申请人提供)：该奖项的两个主要目标是提高我作为一名有效导师的能力，同时也提供培训，使年轻研究人员能够成功竞争K23奖项和随后的独立资助。一个多样化的教育活动、正在进行的研究和未来研究的潜力的平台可以帮助培训以患者为导向的研究(POR)的肺科医生。在整个获奖过程中，我将参加正在进行的教育活动。我将通过参加每周一次的基础科学研究会议来提高对肺部疾病基础研究的理解。我将学习统计学课程，以扩展我在分析纵向和集群数据、高通量分子、遗传和表观遗传学数据以及临床试验和生存分析中的先进概念方面的知识。我将通过机构审查委员会赞助的课程以及密歇根临床与健康研究所/临床与翻译科学奖(MICHR/CTSA)的课程继续我的培训，即负责任地进行研究。学员的基本指导计划包括POR中的个别化研究项目、预定的导师会议、与统计学家的密切合作、针对统计和负责任的研究行为的正式教育活动，以及预定的来自指导团队的正式反馈。UM多学科培训补助金(T32 HL07749-18)和与MICHR/CTSA的密切合作为更多年的研究生培训和生物统计学和临床研究设计硕士学位提供资金。目前为POR的未来受训人员提供了一系列多样化的研究机会。这些项目提供了已建立的可立即使用的数据库、可被操纵到数据库中的原始数据以及前瞻性收集新数据(包括患者样本)的能力。资助的研究项目包括评估用于特发性肺纤维化患者的临床试验的计算机辅助图像分析软件的使用、评估预测特发性肺纤维化患者未来病程的潜在生物标记物、参与特发性肺纤维化临床研究网络和肺组织研究联盟。该申请还提出了两个新的研究项目。第一个项目确定了高分辨率计算机断层扫描特征预测晚期特发性肺纤维化患者对西地那非治疗反应的能力。这项研究利用了通过IPFnet获得的数据。第二个项目将创建一个数据库，并研究人类样本，以提高我们对过敏性肺炎的诊断、结果预测因素和病理生物学的理解。

项目成果

Nonparametric restricted mean analysis across multiple follow-up intervals.

多个随访间隔的非参数限制均值分析。

• DOI: 10.1016/j.spl.2015.11.014
• 发表时间: 2016
• 期刊: Statistics & probability letters
• 影响因子: 0.8
• 作者: Tayob,Nabihah;Murray,Susan
• 通讯作者: Murray,Susan

Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials.

• DOI: 10.1186/1465-9921-14-73
• 发表时间: 2013-07-13
• 期刊: Respiratory research
• 影响因子: 5.8
• 作者: Collard HR;Yow E;Richeldi L;Anstrom KJ;Glazer C;IPFnet investigators
• 通讯作者: IPFnet investigators