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Cardiac Toxicity in Perinatally HIV-infected Adolescents and Young Adults, a Longitudinal Study

围产期 HIV 感染青少年和年轻人的心脏毒性，一项纵向研究

基本信息

批准号：
9349153
负责人：
STEVEN EDWARD LIPSHULTZ
金额：
$ 89.3万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9349153
关键词：
Adolescent Adolescent and Young Adult Anti-HIV Agents Atherosclerosis Biological Assay Biological Markers Blood Pressure Cardiac Cardiac Myocytes Cardiotoxicity Cardiovascular Abnormalities Cardiovascular Diseases Cardiovascular system Cells Characteristics Child Childhood Chronic Clinical Echocardiography Epidemic Event Exposure to Future Goals HIV HIV-infected adolescents Heart Heart Rate Heart failure Highly Active Antiretroviral Therapy Individual Inflammation Inflammatory Intervention Lead Left Left ventricular structure Longitudinal Studies Lung Measurement Measures Mitochondria Mitochondrial DNA Morbidity - disease rate National Heart, Lung, and Blood Institute Oxidative Phosphorylation Oxidative Stress Oxygen Consumption Pediatric HIV/AIDS Cohort Study Perinatal Peripheral Blood Mononuclear Cell Population Protocols documentation Recommendation Reporting Respiration Risk Risk Factors Role Severities Severity of illness Stress Structure Symptoms Time United States National Institutes of Health Ventricular Visit Youth antiretroviral therapy cardiovascular disorder risk cardiovascular risk factor cohort disorder risk enzyme activity follow-up lifestyle intervention mitochondrial dysfunction mortality pediatric human immunodeficiency virus premature screening young adult

项目摘要

Project Summary While the widespread use of highly active antiretroviral therapy has markedly decreased cardiac morbidity and mortality in perinatally HIV-infected children, several studies have suggested subclinical abnormalities in echocardiographic measures of left ventricular structure and function. The goal of this study is to longitudinally evaluate the cardiovascular status of perinatally HIV-infected adolescents and young adults and to explore whether chronic inflammation and/or mitochondrial abnormalities are associated with echocardiographic and biomarker changes over time. The specific aims of this study are to 1) to determine longitudinal changes of cardiovascular risk factors that were assessed ~6 years ago in the AMP (adolescents) and AMP Up (young adults) perinatally HIV-infected (PHIV) and HIV-exposed, uninfected (HEU) cohorts of the Pediatric HIV/AIDS Cohort Study (PHACS) and to measure modified Pathobiological Determinants of Atherosclerosis in Youth or PDAY scores (a measure of aggregate cardiovascular risk) in HIV-infected adolescents longitudinally; and 2) to evaluate the role of systemic mitochondrial function in abnormalities of cardiovascular measures and biomarkers by assaying for mitochondrial oxygen consumption (respiration) and oxidative stress. The results of this study can identify if there are perinatally HIV-infected adolescents and young adults, with long term exposure to HAART, which are at increased risk of future cardiovascular morbidities. If this is the case, the results of this study can inform various interventions in this increased cardiovascular risk group to decrease their future risk of adverse cardiovascular events.

项目总结