WG3: HIV, Co-infections and Co-morbidities

尽管抗逆转录病毒疗法(ART)极大地改变了艾滋病毒感染和 在提高患者存活率的同时，受感染的患者继续遭受结核病的显著发病率和死亡率， 心血管疾病、恶性肿瘤、慢性肾脏疾病和神经认知疾病。这些问题突显了这样一个事实：虽然艺术 在限制病毒复制方面非常有效，因此迫切需要解决共病的决定因素， 这是艾滋病毒研究中的关键问题，也是第三工作组议程的重点。这个 专家组的任务是为CFAR确定这一领域的科学优先事项，然后促进在 通过促进协同互动和协作研究提案，推动 初级调查员。工作组有23名成员，包括大量临床和翻译人员 研究人员在上一个资助周期共发表了423篇同行评议的出版物。这个 WG3的主要目标是促进CWRU和其他研究人员之间的互动和合作 以揭开艾滋病毒感染的生物共病条件。 工作组通过各种活动促进这一科学议程，包括：(1)促进合作 通过赞助研讨会、期刊俱乐部、研究进行中的会议和有针对性的会议来进行研究 讨论艾滋病毒倡议，(2)组建和参与国家研究联盟，以促进和传播 艾滋病毒研究，以及(3)指导和促进初级调查人员的职业生涯。通过这些活动，WG3 将促进以下具体目标： ·将在来自不同学科的调查人员之间开发新的互动。关键科学 优先事项包括： ·，以刺激多调查员项目的形成。WG2的成功将由 推进新的协作项目，包括： ·，以促进工作组之间的交叉受精。 总之，工作组致力于促进抗逆转录病毒疗法时代艾滋病毒研究的关键科学优先事项。这 将通过旨在促进CWRU/UH内部合作的有针对性的活动来支持议程 CFAR，开发CFAR核心的支持资源，特别是临床核心D和乌干达实验室 核心C.工作组重视聘用新的调查人员，并有良好的支持记录。 指导科学家领航资助金和催化基金获奖者的工作。

Although antiretroviral therapy (ART) has dramatically altered the prognosis of HIV infection and improved the survival of patients, infected patients continue to suffer significant morbidity and mortality from TB, CVD, malignancies, chronic kidney, and neurocognitive disease. These issues highlight the fact that while ART is very effective at restricting viral replication, there is a pressing need to address the determinants of comorbidities, which are the critical issues in HIV research and the focus of the Working Group 3 agenda. The group has a remit to define scientific priorities in this area for the CFAR and then to facilitate advances in the field by promoting synergistic interactions and collaborative research proposals and advancing the careers of junior investigators. Working Group has 23 members, comprising a critical mass of clinical and translational researchers who have collectively published 423 peer-reviewed publications during the last funding cycle. The primary goal of WG3 is to promote interactions and collaborations between researchers at CWRU and beyond to unravel the biology co-morbid conditions in HIV infections. WG3 promotes this scientific agenda through a variety of activities including (1) facilitating collaborative research by sponsoring seminars, journal clubs, research-in-progress meetings, and targeted meetings to discuss HIV initiatives, (2) forming and participating in national research consortia to promote and disseminate HIV research, and (3) mentoring and promoting the careers of junior investigators. Through these activities, WG3 will promote the following Specific Aims: • To develop new interactions among investigators from various disciplines. Key scientific priorities are: • To stimulate the formation of multi-investigator projects. WG2 success will be defined by the advancement of new collaborative projects, including: • To stimulate cross-fertilization between working groups. In summary, WG3 is focused on promoting key scientific priorities for HIV research in the ART era. This agenda will be supported through targeted activities designed to foster collaborations within the CWRU/UH CFAR, develop supporting resources in the CFAR Cores, especially the Clinical Core D and Uganda Laboratory Core C. The WG3 has placed emphasis on engaging new investigators and has an excellent record of supporting the work of Mentored Scientist Pilot Grant and Catalytic Fund awardees.