课题基金 / 基金详情

Novel Melanocortin Receptor Probe Discovery

Novel Melanocortin Receptor Probe Discovery
新型黑皮质素受体探针的发现
批准号：
9449442
负责人：
Carrie Haskell-Luevano
金额：
$37.62万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
项目状态：
已结题
起止时间：
2016-04-01 至 2020-03-31
来源：
https://reporter.nih.gov/project-details/9449442
关键词：
ART proteinAdverse effectsAffectAgonistAmino AcidsAreaBindingBody mass indexBrainCentral Nervous System AgentsClinical TrialsComplexCountryCoupledDataDeveloped CountriesDietDiseaseExerciseFatty acid glycerol estersGTP-Binding ProteinsGenesGeneticGoalsHeart DiseasesHomeostasisHomodimerizationHumanHyperphagiaHypertensionKnowledgeLigandsLinkMalignant NeoplasmsMediatingMelanocortin 3 ReceptorMelanocortin 4 ReceptorModificationMolecularMolecular Mechanisms of ActionMolecular ProbesMorbidity - disease rateMusN-terminalNeurosecretory SystemsNon-Insulin-Dependent Diabetes MellitusObesityOutcomePOMC genePathway interactionsPharmaceutical ChemistryPharmacologyPhysiologicalPro-OpiomelanocortinRegulationReportingResearchResearch Project GrantsRisk FactorsRoleSatiationStrokeTertiary Protein StructureTherapeuticTranscriptUnited StatesWeightantagonist Gbasedesigndrug discoveryfeedingmelanocortin receptornovelpublic health relevancereceptorreceptor bindingtherapeutic developmenttherapeutic targettool

项目摘要

项目成果

Carrie Haskell-Luevano的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
 DESCRIPTION (provided by applicant): Obesity afflicts millions of people, and is a major risk factor for Type II diabetes and morbidity. The melanocortin pathway has been clearly identified in mice and humans to be involved in the regulation of satiety, obesity, and energy homeostasis. The goal of this research project is characterize the human melanocortin-4 receptor (MC4R) N- terminal 1-26 domain peptide agonist, identify how it molecularly interacts with the MC4R to mechanistically function as a full agonist. These data will be used to generate novel and potent MC4R agonist molecules as molecular probes and potential central nervous system (CNS) drugs. The impact of the anticipated results on the medicinal chemistry and obesity research fields could challenge the existing paradigms for ligand design strategies for melanocortin receptor based therapeutics, GPCR based therapeutics, as well as provide novel tools to probe weight and energy homeostasis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Chemical biology of Peptide Regulation of Opioid Receptor Function
  • 批准号：
    10578830
  • 项目类别：
  • 资助金额：
    $63.05万
  • 财政年份：
    2020
  • 负责人：
    Carrie Haskell-Luevano
  • 依托单位：
    UNIVERSITY OF MINNESOTA
Chemical biology of Peptide Regulation of Opioid Receptor Function
  • 批准号：
    10348174
  • 项目类别：
  • 资助金额：
    $63.83万
  • 财政年份：
    2020
  • 负责人：
    Carrie Haskell-Luevano
  • 依托单位：
    UNIVERSITY OF MINNESOTA
Novel Melanocortin Receptor Probe Discovery
  • 批准号：
    9077902
  • 项目类别：
  • 资助金额：
    $37.21万
  • 财政年份：
    2016
  • 负责人：
    Carrie Haskell-Luevano
  • 依托单位：
    UNIVERSITY OF MINNESOTA
Novel Melanocortin Receptor Probe Discovery
  • 批准号：
    9235279
  • 项目类别：
  • 资助金额：
    $37.39万
  • 财政年份：
    2016
  • 负责人：
    Carrie Haskell-Luevano
  • 依托单位：
    UNIVERSITY OF MINNESOTA
海外基金