Cardiothoracic Surgical Trials Network Linked Clinical Research Centers for Virginia and West Virginia

项目摘要 这份提案记录了弗吉尼亚大学(UVA)对 NIHLBI/NINDS赞助的心血管内科心胸外科研究网络 八个核心站点之一。这些重要贡献跨越了从领导到参与 多个协议制定委员会，一直是CTSN试验的顶级参与者之一，以及 成功地作为网络中的三个技能发展计划之一发挥作用。UVA执行1100-1200 每年可在临床研究中招募的成人心脏手术是最高的 机构优先。UVA调查小组由心脏外科主任Gorav Ailawadi博士领导 以及一位活跃的心脏外科医生，他在该网络中活跃了10年，并与多个委员会合作 和领导角色。艾拉瓦迪博士还在弗吉尼亚州心脏服务质量倡议中担任领导职务 旨在改善弗吉尼亚州的心脏护理，这是实施科学的成功典范。UVA团队 一直高度致力于外科医生、心脏病专家和神经学家之间的密切合作 几乎在每个CTSN试验中都有一致的最高登记人数。UVA将作为经验丰富的网络站点在 并将与西弗吉尼亚大学(WVU)经验较少的Site合作，后者自豪地关心 对于以高质量临床护理著称的大量未得到充分服务的人群。最近，伟大的投资 已经做出努力发展由Vinay Badhwar博士领导的西弗吉尼亚大学心脏和血管研究所，作为一个综合性的 一位领导者领导下的心脏外科和心脏病学相结合的服务线模式。巴德瓦博士是一位著名的 在我们的主要社会中具有国家领导作用的心脏外科医生，以及与 工业。他已经招募了几名顶尖的外科医生、心脏病专家和成像师，他们的记录都很出色 在临床试验和高质量的护理中。此外，西弗吉尼亚大学最近的重组产生了重大的 对研究基金和基础设施的投资。总的来说，这些投资使西弗吉尼亚大学成为一个理想的加盟地点 该网络有能力和能力为患者登记和试验设计做出巨大贡献。此外，我们的 网站为独特的服务不足、心血管疾病负担较高的患者提供服务，这些患者来自 接受他们照顾的距离。我们的具体目标集中在三个方面：1)优化参与和利用 在我们两家公司的CTSN试验中招募和留住患者的创新方法 机构。2)以快速方式指导和建设西弗吉尼亚大学作为新的附属网站的能力，从而 对网络的直接贡献。3)支持临床和实施技能的发展 广泛覆盖我们机构的受训者和受训者，以培养未来临床研究的领导者 心脏护理。

Project Summary This proposal documents the significant contributions that the University of Virginia (UVA) has made to the NIHLBI/ NINDS sponsored Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine as one of eight core sites. These important contributions have spanned from leading and participating in numerous protocol development committees, consistently being one of the top enrollers in CTSN trials, and successfully functioning as one of 3 Skills Development Programs in the network. UVA performs 1100-1200 adult cardiac procedures annually which are available for recruitment in clinical research as the highest institutional priority. The UVA investigative group is led by Dr. Gorav Ailawadi, the Chief of Cardiac Surgery and an active cardiac surgeon, who has been active in the Network for 10 years with a number of committee and leadership roles. Dr. Ailawadi also has leadership roles in the Virginia Cardiac Services Quality Initiative designed to improve cardiac care in Virginia, a successful model for implementation science. The UVA team has been highly committed with strong collaboration among surgeons, cardiologists, and neurologists evidence by consistent top enrollment in nearly every CTSN trial. UVA will function as the experienced network site in this proposal and will partner with less experienced site in West Virginia University (WVU) who proudly cared for a large underserved population with a reputation for high quality clinical care. Recently, great investments have been made to develop the WVU Heart and Vascular Institute, led by Dr. Vinay Badhwar, as an integrated service line model combining cardiac surgery and cardiology under a single leader. Dr. Badhwar is a renowned cardiac surgeon with national leadership roles in our major societies as well as strong relationships with industry. He has recruited several top notch surgeons, cardiologists, and imagers with excellent track records in clinical trials and high quality care. Moreover, the recent reorganization at WVU has resulted in a significant investment in research funds and infrastructure. Collectively, these investments make WVU an ideal site to join the Network, with ability and capacity to contribute highly to patient enrollment and trial designs. Further, our sites serve unique underserved patients with high cardiovascular disease burden, who travel from great distances to receive their care. Our specific aims focus on three areas: 1) To optimize participation and utilize novel and innovative approaches for the recruitment and retention of patients in CTSN trials among our two institutions. 2) To mentor and build capacity for WVU as a new affiliate site in a rapid fashion allowing immediate contributions to the Network. 3) To support the development of clinical and implementation skills broadly across trainees and mentees across our institutions to develop future leaders in clinical research in cardiac care.