Cardiothoracic Surgical Trials Network Linked Clinical Research Centers for Virginia and West Virginia

项目摘要 该提案记录了弗吉尼亚大学（UVA）对该项目所做的重大贡献。 NIHLBI/ NINDS赞助的心血管医学心胸外科研究网络， 八个核心站点之一。这些重要贡献包括领导和参与 众多的方案制定委员会，一直是CTSN试验的最大招募者之一，以及 作为网络中的三个技能发展方案之一成功运作。UVA性能1100-1200 成人心脏手术，每年可用于临床研究招募的最高 机构优先。UVA调查小组由心脏外科主任Gorav Ailawadi博士领导 他是一名活跃的心脏外科医生，在该网络中活跃了10年， 和领导角色。Ailawadi博士还在弗吉尼亚心脏服务质量倡议中担任领导职务 旨在改善弗吉尼亚州的心脏护理，这是实施科学的成功典范。UVA团队 一直高度致力于与外科医生，心脏病学家和神经学家之间的强有力合作， 在几乎所有的CTSN试验中，UVA将作为经验丰富的网络站点， 这一建议，并将合作伙伴与经验不足的网站在西弗吉尼亚大学（WVU）谁自豪地关心 为大量服务不足的人群提供高质量的临床护理。最近， 已经发展了西弗吉尼亚大学心脏和血管研究所，由Vinay Badhwar博士领导，作为一个综合的 在一个领导人的领导下，将心脏外科和心脏病学结合起来的服务线模式。巴德瓦博士是一位著名的 心脏外科医生在我们的主要社会中担任国家领导角色，并与 行业他已经招募了几位顶尖的外科医生、心脏病专家和成像师，他们都有出色的记录。 在临床试验和高质量的护理中。此外，西弗吉尼亚大学最近的重组导致了一个重大的 投资研究基金和基础设施。总的来说，这些投资使西弗吉尼亚大学成为一个理想的网站加入 网络，有能力和能力为患者招募和试验设计做出巨大贡献。此外，我们的 站点为独特的心血管疾病负担高的服务不足的患者提供服务，这些患者从大城市旅行， 远距离的照顾。我们的具体目标集中在三个方面：1）优化参与和利用 在我们的两项CTSN试验中， 机构职能体系2)指导和建设能力西弗吉尼亚大学作为一个新的附属网站在快速的方式， 立即为网络捐款。3)支持临床和实施技能的发展 在我们机构的学员和学员中广泛传播，以培养未来的临床研究领导者， 心脏护理

Project Summary This proposal documents the significant contributions that the University of Virginia (UVA) has made to the NIHLBI/ NINDS sponsored Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine as one of eight core sites. These important contributions have spanned from leading and participating in numerous protocol development committees, consistently being one of the top enrollers in CTSN trials, and successfully functioning as one of 3 Skills Development Programs in the network. UVA performs 1100-1200 adult cardiac procedures annually which are available for recruitment in clinical research as the highest institutional priority. The UVA investigative group is led by Dr. Gorav Ailawadi, the Chief of Cardiac Surgery and an active cardiac surgeon, who has been active in the Network for 10 years with a number of committee and leadership roles. Dr. Ailawadi also has leadership roles in the Virginia Cardiac Services Quality Initiative designed to improve cardiac care in Virginia, a successful model for implementation science. The UVA team has been highly committed with strong collaboration among surgeons, cardiologists, and neurologists evidence by consistent top enrollment in nearly every CTSN trial. UVA will function as the experienced network site in this proposal and will partner with less experienced site in West Virginia University (WVU) who proudly cared for a large underserved population with a reputation for high quality clinical care. Recently, great investments have been made to develop the WVU Heart and Vascular Institute, led by Dr. Vinay Badhwar, as an integrated service line model combining cardiac surgery and cardiology under a single leader. Dr. Badhwar is a renowned cardiac surgeon with national leadership roles in our major societies as well as strong relationships with industry. He has recruited several top notch surgeons, cardiologists, and imagers with excellent track records in clinical trials and high quality care. Moreover, the recent reorganization at WVU has resulted in a significant investment in research funds and infrastructure. Collectively, these investments make WVU an ideal site to join the Network, with ability and capacity to contribute highly to patient enrollment and trial designs. Further, our sites serve unique underserved patients with high cardiovascular disease burden, who travel from great distances to receive their care. Our specific aims focus on three areas: 1) To optimize participation and utilize novel and innovative approaches for the recruitment and retention of patients in CTSN trials among our two institutions. 2) To mentor and build capacity for WVU as a new affiliate site in a rapid fashion allowing immediate contributions to the Network. 3) To support the development of clinical and implementation skills broadly across trainees and mentees across our institutions to develop future leaders in clinical research in cardiac care.