National Clinical Trials Network Research at the University of Wisconsin

威斯康星大学国家临床试验网络研究

• 批准号: 9888349
• 负责人: Lisa M Barroilhet
• 金额: $ 55.93万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-06 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9888349
• 关键词: American College of Radiology Imaging Network; American College of Surgeons Oncology Group; Cancer Burden; Cancer Center; Cancer Patient; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Cooperative Group Program; Data; Development; Eastern Cooperative Oncology Group; Ensure; Faculty; Goals; Grant; Gynecologic Oncology; Gynecologic Oncology Group; Image; Imaging Techniques; Infrastructure; Leadership; Malignant Neoplasms; Medical Oncology; Mission; Modernization; NCI Center for Cancer Research; National Clinical Trials Network; Oncology; Phase; Phase II/III Clinical Trial; Population; Population Heterogeneity; Prevention; Principal Investigator; Protocols documentation; Radiation Oncology; Radiation Therapy Oncology Group; Research; Research Infrastructure; Research Personnel; Resources; Strategic Planning; Structure; Surgical Oncology; Therapeutic; Time; Translational Research; Underserved Population; Universities; University of Wisconsin Comprehensive Cancer Center; Wisconsin; cancer clinical trial; cancer education; cancer therapy; data management; design; experience; innovation; interdisciplinary approach; interest; multidisciplinary; next generation; novel; programs; treatment trial

Project Summary/Abstract The University of Wisconsin Carbone Cancer Center (UWCCC), its leadership, and its faculty are driven by a mission to defeat cancer through rapid application of groundbreaking research in cancer education, prevention and treatment. Embedded in the UWCCC's strategic plan are tactics for expanding a modern research platform inclusive of a comprehensive clinical research program with exemplary data management and clinical trial prioritization as well as scientific oversight and leadership. The UWCCC NCTN LAPs multi-disciplinary team remains an integral component of this strategic initiative and collaborates with key faculty to support innovative translational research for next generation clinical trials within the NCI's National Clinical Trials Network. Since 1974, UWCCC faculty have functioned as leaders in the development of the NCI cancer cooperative group program; first within ECOG and then with RTOG, ACOSOG and GOG in the early 2000s. As the NCI and its NCTN transitioned to a centralized infrastructure in 2014, the UWCCC designed a LAPS team of collaborative principal investigators by combining the existing broad scientific leadership from three of the primary cooperative groups (ECOG/ACRIN, NRG and ALLIANCE). This multi-disciplinary approach with leaders from Surgical, Medical, Radiation and Gynecologic Oncology, facilitated an innovative governance structure to provide leadership and oversight in prioritization of Phase II/III clinical trials, timely trial activation and robust accrual as well as the development of junior faculty interested in oncologic clinical research. In the four years since our last grant submission, the UWCCC LAPS team has provided support for the important genomically-directed clinical trials as well as those with a focus on advanced imaging, while strengthening our Cancer Center's infrastructure. This UG1 application seeks support for continuing the NCTN activities within the UWCCC. This partnership remains an important mechanism for providing a diverse population of cancer patients with novel treatment approaches, as well as a means for providing resources and support for existing and new leaders within the NCTN to bring innovative translational projects to Phase II/III clinical trials.

项目总结/摘要 威斯康星州Carbone癌症中心（UWCCC）的大学，它的领导，它的教师是由一个驱动， 使命：通过在癌症教育、预防和治疗领域迅速应用突破性研究成果， 和治疗。在UWCCC的战略计划中嵌入了扩展现代研究平台的策略 包括具有示范性数据管理和临床试验综合临床研究计划 优先次序以及科学监督和领导。UWCCC NCTN LAPS多学科团队 仍然是这一战略举措的一个组成部分，并与主要教师合作，以支持创新 在NCI的国家临床试验网络内进行下一代临床试验的转化研究。 自1974年以来，UWCCC教师一直担任NCI癌症合作小组发展的领导者 计划;首先在ECOG内，然后在21世纪初与RTOG，ACOSOG和GOG合作。作为NCI及其 NCTN在2014年过渡到集中式基础设施，UWCCC设计了一个LAPS团队， 主要研究人员通过结合现有的广泛的科学领导，从三个主要的合作 各组（ECOG/ACRIN、NRG和ALLIANCE）。这种多学科的方法与领导人从外科， 医疗、放射和妇科肿瘤学，促进了创新的治理结构， 领导和监督II/III期临床试验的优先顺序，及时启动试验和稳健的应计费用， 以及对肿瘤临床研究感兴趣的初级教师的发展。自从我们上次见面后的四年里 拨款提交，UWCCC LAPS团队为重要的基因组定向临床研究提供了支持。 我们将继续为临床试验以及那些专注于先进成像的试验提供支持，同时加强我们癌症中心的基础设施。 此UG 1应用程序寻求在UWCCC内继续NCTN活动的支持。这种伙伴关系 仍然是为不同人群的癌症患者提供新型治疗的重要机制 以及为联合国系统内现有和新的领导人提供资源和支持的手段。 NCTN将创新的转化项目带入II/III期临床试验。