Comparative Pathology Core

比较病理学核心

• 批准号: 9535698
• 负责人: Amy Cleveland Durham
• 金额: $ 18.82万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9535698
• 关键词: American; Anatomy; Animal Cancer Model; Animal Model; Autopsy; Cancer Center; Cancer Center Support Grant; Comparative Pathology; Consultations; Dermatopathology; Development; Disease model; Evaluation; Funding; Histology; Histopathology; Image; Immunohistochemistry; Laboratories; Lead; Lesion; Malignant Neoplasms; Melissa; Monitor; Mus; Oral Pathology; Pathologist; Pathology; Pediatric Oncology; Pennsylvania; Phenotype; Preparation; Radiobiology; Research; Research Personnel; Research Project Grants; Resource Sharing; Services; Slide; Stains; Therapeutic; Training; Tumor Biology; Universities; Veterinary Medicine; Veterinary Schools; Work; anticancer research; cancer immunobiology; college; experience; histological slides; malignant breast neoplasm; medical specialties; member; mouse model; professor; programs; service utilization; success

Project Summary The Comparative Pathology Core is an established Core within the University of Pennsylvania School of Veterinary Medicine that has been integrated into the Abramson Cancer Center (ACC) and is presented as a newly established Shared Resource for NCI approval and CCSG funding. As such, the Core will enable the ACC to fulfill the growing needs of members who are using animal models. Amy Durham, MS, VMD, Diplomate of the American College of Veterinary Pathologists (DACVP) and Assistant Professor in the Department of Pathobiology at the School of Veterinary Medicine, developed and directs the Core. Dr. Durham is a board- certified anatomic veterinary pathologist with considerable experience in animal models of cancer, and has been involved in numerous collaborative research projects with members of the ACC and others throughout the Penn campus. Recognition and accurate interpretation of gross and histopathological lesions in animal models is essential for the success of cancer research. Currently, Core pathologists work with ACC members from multiple Research Programs, including Tumor Biology, Cancer Therapeutics, Breast Cancer, Immunobiology, Radiobiology and Imaging, and Pediatric Oncology. Among the services that have been provided are: mouse phenotyping, comprehensive slide evaluation and interpretation, consultation, autopsy training, and photomicroscopy. Additional services utilize the Core's histology laboratory to provide histopathology slide preparation, as well as special histochemical and immunohistochemical staining. Working with the Facility Director, Dr. Durham, is Dr. Elizabeth Buza, who is the Core's Technical Director and lead pathologist. Dr. Buza has expertise in mouse pathology and additional training in mouse models of disease from Novartis and Jackson Labs, and she has worked with Dr. Durham for several years. There are several board-certified anatomic pathologists who support Drs. Durham and Buza, and are available to provide specialty expertise depending on the investigator's particular needs. They include Dr. Julie Engiles (osteopathology), Dr. Elizabeth Mauldin (dermatopathology), and Dr. Melissa Sánchez (oral pathology and immunohistochemistry). The Core currently serves 12 ACC members which, represents a doubling in ACC member usage since the announcement of the Core as an ACC Shared Resource in July 2013. Thus, as cancer research using mouse models continues to expand, Core utilization by ACC members is predicted to grow substantially.

项目摘要 比较病理学核心是宾夕法尼亚大学医学院内的一个既定核心， 兽医已被纳入艾布拉姆森癌症中心（ACC），并作为一个 新设立的共享资源，用于NCI批准和CCSG资助。因此，核心将使 ACC满足使用动物模型的成员日益增长的需求。Amy达勒姆，MS，VMD，文凭 美国兽医病理学家学院（DACVP）的副教授， 病理生物学在兽医学院，开发和指导核心。达勒姆医生是董事会- 在癌症动物模型方面具有丰富经验的认证解剖兽医病理学家， 一直参与许多合作研究项目与成员的行政协调会和其他整个 宾夕法尼亚大学校园识别和准确解释动物的大体和组织病理学病变 模型对于癌症研究的成功至关重要。目前，核心病理学家与ACC成员合作 来自多个研究项目，包括肿瘤生物学，癌症治疗，乳腺癌， 免疫生物学、放射生物学和成像学以及儿科肿瘤学。在这些服务中 提供的是：小鼠表型分析、全面的载玻片评价和解释、咨询、尸检 培训和显微镜其他服务利用核心的组织学实验室提供 组织病理学切片制备，以及特殊组织化学和免疫组织化学染色。工作 与设施主任达勒姆博士一起的是伊丽莎白·布扎博士，她是核心的技术主任和负责人 病理学家Buza博士拥有小鼠病理学方面的专业知识，并接受过小鼠疾病模型方面的额外培训。 来自诺华和杰克逊实验室，她已经与达勒姆博士合作了好几年。有几 董事会认证的解剖病理学家谁支持博士.达勒姆和布扎，并提供 专业知识，取决于研究者的特殊需要。其中包括朱莉·英格尔斯博士 Elizabeth Mauldin博士（皮肤病理学）和Melissa Sánchez博士（口腔病理学和 免疫组织化学）。核心目前为12个行政协调会成员提供服务，这意味着行政协调会的成员增加了一倍。 自2013年7月宣布将核心资源作为ACC共享资源以来，因此如 使用小鼠模型的癌症研究继续扩大，ACC成员的核心利用率预计将 大幅增长。