Maintenance of bone strength in aged rats: the Vitamin D requirement

维持老年大鼠骨强度：维生素 D 需求

• 批准号: nhmrc : 453510
• 负责人: A/Pr Brian May
• 金额: $ 36.23万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/maintenance-bone-strength-d-requirement/82980
• 关键词: Maintenance; bone; strength; aged; rats

Hip fracture remains the most devastating of the osteoporotic fractures particularly in women in whom the incidence increases to about 3% per annum by the ninth decade. This incidence is bound to increase as the population ages with increasing longevity. Supplementation of diets of elderly female nursing home residents with vitamin D and calcium has been shown to reduce the risk of hip fracture by 30% in two years. However we do not know how much vitamin D is necessary to maintain optimal bone strength. This project will determine the level of vitamin D required to maintain optimal bone strength in aged rats using a simple blood test which could then be used to screen the elderly and identify those at risk of hip fracture from low vitamin D levels. The project will also investigate the effects of vitamin D on the bone cells that maintain optimal skeletal architecture. This information is essential for comparison with the current knowledge of other biochemical bone markets in blood and vitamin D status in the elderly, in order to develop nutritional recommendations to reduce the incidence of hip fracture.

髋部骨折仍然是最具破坏性的腰椎骨折，特别是在女性中，到第九个十年，其发病率增加到每年约3%。随着人口老龄化和寿命延长，这种发病率必然会增加。在养老院老年女性居民的饮食中补充维生素D和钙已被证明可以在两年内将髋部骨折的风险降低30%。然而，我们不知道需要多少维生素D来维持最佳的骨骼强度。该项目将使用简单的血液测试来确定老年大鼠保持最佳骨骼强度所需的维生素D水平，然后可以用于筛选老年人并确定那些因维生素D水平低而有髋部骨折风险的人。该项目还将研究维生素D对维持最佳骨骼结构的骨细胞的影响。这一信息对于与血液中其他生化骨市场和老年人维生素D状况的现有知识进行比较至关重要，以便制定营养建议以减少髋部骨折的发生率。