Nutrition, Biostatistics & Bioinformatics Training Grant

营养学、生物统计学

• 批准号: 9763451
• 负责人: Raymond J. Carroll
• 金额: $ 20.22万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9763451
• 关键词: Bioinformatics; Biometry; Grant; Training; nutrition

Project Summary/Abstract This is a continuation proposal that will transition us from the R25T mechanism (that no longer exists) to the T32 mechanism. Our goal in this continuation proposal is to train statistically and computationally oriented individuals (Biostatisticians, Statisticians, Engineers, Computer Scientists, etc.) to function as independent researchers in a multidisciplinary environment focusing on cancer research, researchers who are trained in the fundamentals of Nutrition and Cancer. To achieve this goal we have assembled a team specializing in Biostatistics/Statistics, Bioinformatics, Nutrition and multiple aspects of Cancer. As of January 1, 2016, 26 post- doctoral trainees have completed the program and 1 will be enrolled. We have deliberately reduced the number of trainees due to the uncertainty about continued funding. The Program has the following important aspects. 1) The training is fully multidisciplinary. a) We focus on training statistically and computationally oriented individuals in the biology of Nutrition and Cancer, creating researchers who understand the underlying mechanisms of action in the relationship between Nutrition and Cancer. Such understanding will allow our trainees to contribute at the highest level to the design and analysis of experiments in the area, and to develop fine-tuned statistical methods truly appropriate for the experimental data. b) The statistical and computational methods learned will not typically be from formal courses, but as they arise from experimental data in nutrition laboratories. c) The training will include initial rotations through 3 laboratories; a rotation with the Texas A&M Genomics Facility Quantitative Biology Core, the co-director of which is a diet chemoprevention cancer biologist in our training program; a rotation through the newly created metabolomics facility, the director of which is a mentor in our training program; followed by intensive long-term training in a single laboratory. 2) Each trainee will have at least two mentors. a) A Nutritionist or Cancer research specialist whose research focuses on cancer etiology and prevention. The trainee will be expected to become a full member of the biologist's laboratory, including spending significant time in the laboratory, attending laboratory meetings, consulting for the graduate students and postdoctoral researchers in the laboratory, supervising the analysis of experimental data and eventually posing new problems and approaches. b) A Biostatistician or other computationally oriented individual. Our team includes experts in the analysis of experimental data arising from Nutrition and Cancer, particularly those of a longitudinal nature; the analysis of high throughput expression data; the analysis of proteomics data; the construction and the control of gene regulatory networks, etc. 3) The Principal Investigator (Raymond J. Carroll, Ph.D., a Biostatistician) will continue to devote a significant fraction of his time to the Program. We have also designated a Nutritionist (Nancy Turner, Ph.D.) who will continue to devote a significant fraction of her time in coordinating the Nutrition training. 4) The research mentors focus their efforts on cancer research, and receive their primary research funding from the National Cancer Institute, the National Science Foundation, Department of Defense Breast Cancer Research Program, the National Aeronautics and Space Administration Radiation Biology Program, and the American Institute for Cancer Research. 5) The postdoctoral training is for a minimum of two full years, and in some cases this can be extended to three years. 6) At steady state there will be 4 trainees at any one time, the same number as in the R25T program.

项目总结/摘要 这是一个延续性的建议，将使我们从R25 T机制（不再 #21432;的机制。我们在这个延续计划中的目标是统计培训， 面向计算的个人（生物统计学家，统计学家，工程师，计算机 科学家等）在多学科环境中担任独立研究人员 专注于癌症研究，接受过营养学基础培训的研究人员， 癌为了实现这一目标，我们组建了一个专门从事生物统计学/统计学的团队， 生物信息学，营养学和癌症的多个方面。截至2016年1月1日，26名... 博士研究生已完成该计划，1将被录取。我们特意 由于无法确定能否继续提供资金，减少了受训人员人数。 该方案有以下几个重要方面。 1)培训是多学科的。 a）我们专注于在生物学领域培训统计和计算导向的个人 营养和癌症，创造研究人员谁了解潜在的 营养与癌症关系的作用机制。等 理解将使我们的学员能够在最高水平上为设计做出贡献， 分析该领域的实验，并制定微调的统计方法，真正 适合实验数据。 B）学习的统计和计算方法通常不会来自正式的 课程，而是因为它们来自营养实验室的实验数据。 c）培训将包括通过3个实验室进行的初步轮换;与德克萨斯州的 A&M基因组学设施定量生物学核心，其中的共同主任是饮食 化学预防癌症生物学家在我们的培训计划;通过新的轮换 建立了代谢组学设施，其主任是我们培训计划的导师; 然后在一个实验室里进行长期的强化培训。 2)每个学员将至少有两名导师。 a）研究癌症病因学的营养学家或癌症研究专家 和预防受训者将有望成为生物学家小组的正式成员。 实验室，包括花费大量时间在实验室，参加实验室 会议，为研究生和博士后研究人员提供咨询 实验室，监督实验数据的分析，并最终提出新的 问题和方法。 B）生物统计学家或其他以计算为导向的个人。我们的团队包括专家 在分析《营养与癌症》的实验数据时， 纵向性质;高通量表达数据的分析; 蛋白质组学数据;基因调控网络的构建与控制等。 3)主要研究者（Raymond J.卡罗尔，博士，生物统计学家）将继续 他把很大一部分时间都花在了这个项目上我们还指定了一个 营养学家（Nancy Turner，Ph.D.）她会继续把她的大部分时间 协调营养培训。 4)研究导师专注于癌症研究，并获得他们的主要研究成果。 来自国家癌症研究所，国家科学基金会， 美国国防部乳腺癌研究计划，国家航空和 美国宇航局辐射生物学计划和美国癌症研究所 Research. 5)博士后培训至少为期两年，在某些情况下， 延长至三年。 6)在稳定状态下，任何时候都将有4名受训人员，与R25 T中的人数相同 程序.