Wearable nanocomposite sensor system for diagnosing mechanical sources of low back pain and guiding rehabilitation

可穿戴纳米复合传感器系统，用于诊断腰痛的机械源并指导康复

• 批准号: 9897908
• 负责人: Anton E. Bowden
• 金额: $ 72.56万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-26 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9897908
• 关键词: 3-Dimensional; Accounting; Activities of Daily Living; Address; Affect; Articular Range of Motion; Back; Back Pain; Benchmarking; Biofeedback; Biosensing Techniques; Chronic low back pain; Clinical; Clinical Treatment; Collaborations; Collection; Common Cold; Data; Data Analyses; Diagnosis; Diagnostic; Elastomers; Elements; Ensure; Environment; Exhibits; Funding; General Practitioners; Goals; Infrastructure; Interdisciplinary Study; Joints; Legal patent; Low Back Pain; Machine Learning; Magnetic Resonance Imaging; Measures; Mechanics; Modeling; Modification; Monitor; Motion; Movement; Neck Pain; Neurologic; Pathology; Patient Monitoring; Phase; Phenotype; Population; Procedures; Readiness; Recording of previous events; Recurrence; Rehabilitation therapy; Research; Research Project Grants; Site; Source; Spinal; Surgeon; System; Techniques; Technology; Time; Training; Vertebral column; Visit; Work; base; cohort; cost effective; design; experience; follow up assessment; improved; kinematics; machine learning algorithm; nano; nanocomposite; nanosensors; new technology; off-patent; pain outcome; pain patient; phenotypic data; physical therapist; practical application; prototype; response; sensor; sensor technology; success; technological innovation; tool

PROJECT SUMMARY Back pain has gained the distinction of being the most disabling condition in the world [1-3], affecting 80-90% of the US population at some point in their lifetime, with 29% of the US population having experienced lower back pain within the last 3 months. Back and neck pain are the leading cause of missed work days and rank second only to the common cold as a reason for a visit to the doctor, accounting for approximately 30% of general practitioner visits. Of particular concern is chronic low back pain (cLBP), which is recurrent and often non-responsive to conservative treatments. It has long been recognized that spinal pathology changes the way that we move. Biomechanists, physical therapists, and surgeons each utilize a variety of tools and techniques to assess and interpret qualitative movement changes as a window to understanding potential mechanical and neurological sources of low back pain and as a critical element in their treatment paradigm. However, objectively characterizing and communicating this information is currently impossible, since clinically feasible (e.g., cost-effective, objective, and accurate) tools and quantitative benchmarks do not exist. This proposal addresses the challenge to improve cLBP outcomes through the use of unique, inexpensive, screen-printable, elastomer-based nano-composite piezoresponsive sensors which will be integrated into a SPInal Nanosensor Environment (SPINE Sense System) to measure lumbar kinematics and provide an objective, quantitative platform for diagnosis, monitoring, and follow-up assessment of cLBP.

项目概要 背痛已成为世界上最严重的疾病 [1-3]，影响 80-90% 的美国人口在其一生中的某个阶段，其中 29% 的美国人经历过较低的生活水平 过去 3 个月内出现背痛。背部和颈部疼痛是缺勤和缺勤的主要原因 仅次于普通感冒的就诊原因，约占 30% 全科医生就诊。特别值得关注的是慢性腰痛 (cLBP)，这种疼痛经常反复发作 对保守治疗无反应。 人们早已认识到脊柱病理学改变了我们的移动方式。生物力学学家，物理 治疗师和外科医生各自利用各种工具和技术来评估和解释定性 运动变化是了解下背部潜在机械和神经来源的窗口 疼痛并作为其治疗范式中的关键要素。然而，客观地描述和 目前不可能传达这些信息，因为临床上可行（例如，成本效益高、客观、 且准确）的工具和定量基准并不存在。 该提案解决了通过使用独特、廉价、 可丝网印刷、基于弹性体的纳米复合材料压电响应传感器，将集成到 SPinal 纳米传感器环境（SPINE Sense 系统）用于测量腰部运动学并提供 用于 cLBP 诊断、监测和随访评估的客观、定量平台。