Male Chlamydia infections: The key role of macrophages in testicular dissemination and disrupted spermatogenesis

男性衣原体感染：巨噬细胞在睾丸传播和精子发生中断中的关键作用

• 批准号: nhmrc : 1145825
• 负责人: A/Pr Tim Dargaville
• 金额: $ 58.72万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/male-chlamydia-infections-disrupted-spermatogenesis/1320541
• 关键词: Male; Chlamydia; infections; key; role

Male partners of couples seeking IVF, who are seropositive for Chlamydia, indicating a prior infection, often have significantly impaired sperm quality (reduced motility, increased DNA damage and abnormal sperm morphology). Our studies will define how Chlamydia are transported to the testis from the penis and how chronic chlamydial infection in the testis disrupts sperm development. We will also develop new antibiotic delivery systems to improve treatment of male chlamydial infections.

寻求体外受精的夫妇的男性伴侣，如果衣原体血清检测呈阳性，表明先前感染过，通常会严重损害精子质量（活力降低，DNA损伤增加和精子形态异常）。我们的研究将确定衣原体如何从阴茎运输到睾丸，以及睾丸中的慢性衣原体感染如何破坏精子发育。我们还将开发新的抗生素递送系统，以改善男性衣原体感染的治疗。