Core B: Technology Development and Commercialization

抽象-核心B 克利夫兰诊所在实验室转型方面有着长期的承诺和有据可查的成功 改善患者护理的发现和临床创新。核心B是为TPPG周期创建的 为了加强和协调克利夫兰诊所的优秀资源，并迅速推进 强大的早期实验室发现和技术创新管道已在 将TPPG推向商业化的第一周期。核心B将与项目团队协同工作，以验证和 通过提供对药物发现和开发资源、项目的访问来过渡技术 管理支持和技能发展。核心中心将利用克利夫兰诊所的现有设施 创新(CCI)，由NHLBI资助的克利夫兰诊所NIH加速创新中心(NCAI-CC)， 和NSF资助克利夫兰诊所的创新-兵团中心来促进这些项目的发展 通过有经验的项目管理和加速技能发展来创新项目。核心B将 促进与现有行业合作伙伴(宝洁、雀巢、拜耳、铁木、 克利夫兰心脏实验室、无锡、诺华和强生)，以确保项目的快速发展。这个 TPPG的技术开发和商业化核心(核心B)的总体目标是 建立所需的组织，将当前技术从早期阶段加速到 商业化，并让TPPG调查人员成为转化他们发现的全面合作伙伴 在病人护理方面取得了重大进展。具体目标包括：建立必要的资源 将研究转化为改善哮喘患者护理的高级解决方案(目标1)；提供专家 向项目团队提供项目管理指导(目标2)；提供新的和现有的多样化 教育和指导我们的项目研究人员的资源，包括基础、翻译和临床科学家 生物医学创新和创业精神(目标3)。所有项目都将利用核心B资源。

ABSTRACT – CORE B Cleveland Clinic has a long-standing commitment and documented success in transitioning laboratory discoveries and clinical innovations into improvements in patient care. Core B was created for the TPPG Cycle II in order to enhance and coordinate the outstanding Cleveland Clinic resources, and rapidly advance the strong pipeline of early stage laboratory discoveries and technical innovations that have been generated in Cycle I of the TPPG to commercialization. Core B will work in synergy with the project teams to validate and transition the technologies by providing access to drug discovery and development resources, project management support, and skills development. The Core will leverage the facilities available at Cleveland Clinic Innovations (CCI), NIH Center for Accelerated Innovations at Cleveland Clinic (NCAI-CC) funded by NHLBI, and the NSF funded Innovations-Corps Hub at Cleveland Clinic to promote the development of these innovative projects through experienced project management and accelerated skills development. Core B will facilitate the interactions with the established industry partners (Procter & Gamble, Nestle, Bayer, Ironwood, Cleveland HeartLab, Wuxi, Novartis, and Johnson & Johnson) to insure rapid development of the projects. The overall goal of Technology Development and Commercialization Core (Core B) of the TPPG is to establish the needed organization to accelerate the current technologies from early-stage to commercialization, and engage TPPG investigators to be full partners in transforming their discoveries into high-impact advances in patient care. The Specific Aims include: To establish the resources necessary for translating research into advanced solutions for improving asthma patient care (aim 1); To offer expert project management guidance to the project teams (aim 2), and; To provide new and existing diverse resources to educate and mentor our project researchers including basic, translational, and clinical scientists in biomedical innovation and entrepreneurism (aim 3). All projects will utilize Core B resources.