Multiscale modeling of influenza vaccination strategies for optimal T cell immunity
Multiscale modeling of influenza vaccination strategies for optimal T cell immunity
批准号:
9766363
负责人:
JACOB E KOHLMEIER
金额:
$70.07万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-01 至 2023-05-31
关键词:
AffectAnimalsAntibody-mediated protectionAntigensAttenuatedCD8-Positive T-LymphocytesCell CountCellsChildhoodClinicalComplexDevelopmentEffectivenessEpidemiologic MethodsEpidemiologyEpitopesExhibitsExposure toFailureFeedbackFutureHemagglutininHerd ImmunityHumanHumoral ImmunitiesImmune responseImmunityImmunizationImmunizeImmunologic MemoryIndividualInfectionInfluenzaInfluenza vaccinationKnowledgeLinkLongevityLungMeaslesMemoryModelingOutcomePopulationProteinsRespiratory SystemRoleSeveritiesSurfaceT cell responseT memory cellT-LymphocyteTimeTranscendVaccinatedVaccinationVaccine DesignVaccinesVariantViralVirusYellow Fever Vaccinebasedesign and constructionepidemiological modelexperienceexperimental studyimmunopathologyimprovedinfluenza virus vaccineinfluenzaviruslive attenuated influenza vaccinemathematical modelmulti-scale modelingpandemic diseasepandemic influenzapreventseasonal influenzatransmission processtrivalent influenza vaccinevaccination strategyvaccine effectiveness
中文摘要
项目摘要
目前的流感疫苗提供针对季节性流感毒株的集中抗体介导的保护
包括在疫苗中。然而,它们不能防止共循环的错配菌株,而且,
重要的是,不能提供针对可能导致潜在破坏性大流行的抗原性变化的保护。
该提案调查了T细胞免疫在个体和群体水平上的作用,
广泛的保护,防止不同的流感病毒株。动物和人类研究表明,T细胞可以提供
超越毒株保护,导致更快的病毒清除,减少免疫病理学,
改善临床结果,从而改善诱导流感保护水平的策略,
特异性T细胞至关重要。然而,人们对提高流感特异性抗体的规则知之甚少。
呼吸道中的常驻记忆T细胞面对先前流感的预先存在的体液免疫
感染或接种疫苗。我们将使用多尺度免疫流行病学方法,
在面对预先存在的疾病时,
免疫力和感染在人群中的传播。从这项研究中获得的知识将有助于
指导未来针对流感病毒的疫苗接种工作,以更好地产生广泛的保护性T细胞免疫
在个人和整个人群中。
英文摘要
Project Summary
Current influenza vaccines provide focused antibody-mediated protection against seasonal influenza strains
included in the vaccine. However, they do not protect from co-circulating mismatched strains, and, more
importantly, fail to provide protection against antigenic shifts that can cause potentially devastating pandemics.
This proposal investigates the role of T cell immunity, on both the individual and population levels, in providing
broad protection against diverse influenza strains. Animal and human studies showed that T cells can provide
strain-transcending protection, resulting in more rapid viral clearance, decreased immunopathology, and
improved clinical outcomes, and thus the improvement of strategies to induce protective levels of influenza-
specific T cells are of critical importance. However, little is known about the rules for boosting influenza-specific
resident memory T cells in the respiratory tract in the face of pre-existing humoral immunity from prior influenza
infections or vaccinations. We will use multi-scale immuno-epidemiological methods that link the scales from
the dynamics of infection and immunity within individuals to take of vaccination in the face of pre-existing
immunity and the spread of infection on the population level. The knowledge gained form this study will help
guide future vaccination efforts against influenza viruses to better generate broadly protective T cell immunity
within individuals and across the population.
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会议论文
Cellular and molecular programming of lung resident T cell memory
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批准号:10622510
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项目类别:
-
资助金额:$77.48万
-
财政年份:2020
-
负责人:JACOB E KOHLMEIER
-
依托单位:
Cellular and molecular programming of lung resident T cell memory
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批准号:10115800
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项目类别:
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资助金额:$77.53万
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财政年份:2020
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负责人:JACOB E KOHLMEIER
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依托单位:
Cellular and molecular programming of lung resident T cell memory
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批准号:9894438
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项目类别:
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资助金额:$77.5万
-
财政年份:2020
-
负责人:JACOB E KOHLMEIER
-
依托单位:
Cellular and molecular programming of lung resident T cell memory
-
批准号:10395925
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项目类别:
-
资助金额:$77.52万
-
财政年份:2020
-
负责人:JACOB E KOHLMEIER
-
依托单位:
Multiscale modeling of influenza vaccination strategies for optimal T cell immunity
-
批准号:10189687
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项目类别:
-
资助金额:$68.12万
-
财政年份:2018
-
负责人:JACOB E KOHLMEIER
-
依托单位:
Multiscale modeling of influenza vaccination strategies for optimal T cell immunity
-
批准号:10414951
-
项目类别:
-
资助金额:$66.78万
-
财政年份:2018
-
负责人:JACOB E KOHLMEIER
-
依托单位:
Imprinting of Lung-Resident T Cell Memory
-
批准号:8817929
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项目类别:
-
资助金额:$38.79万
-
财政年份:2014
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负责人:JACOB E KOHLMEIER
-
依托单位:
Imprinting of Lung-Resident T Cell Memory
-
批准号:8960944
-
项目类别:
-
资助金额:$38.79万
-
财政年份:2014
-
负责人:JACOB E KOHLMEIER
-
依托单位:
Imprinting of Lung-Resident T Cell Memory
-
批准号:9185999
-
项目类别:
-
资助金额:$38.79万
-
财政年份:2014
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负责人:JACOB E KOHLMEIER
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依托单位:
Antigen-independent activation of memory CD8 T cells during respiratory infection
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批准号:7898591
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项目类别:
-
资助金额:$28.2万
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财政年份:2009
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负责人:JACOB E KOHLMEIER
-
依托单位:
Antigen-independent activation of memory CD8 T cells during respiratory infection
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批准号:7707582
-
项目类别:
-
资助金额:$22.25万
-
财政年份:2009
-
负责人:JACOB E KOHLMEIER
-
依托单位:
Recruitment of memory CD8+ T cells to the lung airways
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批准号:7275791
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项目类别:
-
资助金额:$5.13万
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财政年份:2007
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负责人:JACOB E KOHLMEIER
-
依托单位:
海外基金