SQSTM1/p62 靶向小分子治疗多发性骨髓瘤疾病-猫眼课题宝

SQSTM1/p62 靶向小分子治疗多发性骨髓瘤疾病

批准号：

9765207

负责人：

James Lee

金额：

$100.0万

依托单位：

ID4PHARMA, LLC

依托单位国家：

美国

项目类别：

财政年份：

2017

资助国家：

美国

项目状态：

已结题

起止时间：

2017-05-23 至 2021-08-31

来源：

https://reporter.nih.gov/project-details/9765207

关键词：

Adaptor Signaling Protein Agreement Antineoplastic Agents Binding Biological Assay Biological Availability Biotechnology Biotin Bone Marrow Bortezomib Cell physiology Cells Chemical Structure Chemicals Chemistry Clinical Data Development Disease Drug Design Drug Targeting Drug resistance Exhibits FDA approved GTF2H1 gene Genetic Goals Grant Growth Hematologic Neoplasms Human In Vitro Inflammation Intelligence Intervention Investigational Drugs Investigational New Drug Application Lead Legal patent Lesion Letters Licensing MAPK14 gene MAPK3 gene Manuscripts Measures Modification Multiple Myeloma Mus Nature Neurodegenerative Disorders Neuropathy Obesity Oral Osteoclasts Ownership Oxis Pathway interactions Patients Pharmaceutical Chemistry Pharmaceutical Preparations Pharmaceutical Technology Pharmacology Phase Physiologic pulse Plague Property Publications Quality Control Relapse Reporting Research Route Signal Pathway Signal Transduction Small Business Innovation Research Grant Specificity Stromal Cells Structure Synthesis Chemistry TNF gene Technology Thrombocytopenia Time Toxic effect Treatment Protocols Work Xenograft procedure Zinc Fingers bone chemical property clinical investigation dosage drug discovery experimental study improved in vivo inhibitor/antagonist innovation knockout gene leukemia mitogen-activated protein kinase p38 mouse model neurogenesis novel off-patent osteoclastogenesis pharmacokinetics and pharmacodynamics pre-clinical preclinical evaluation preclinical study research and development scale up small molecule small molecule inhibitor tumor growth tumorigenesis

期刊论文(0)

专著(0)

科研奖励(0)

会议论文

SQSTM1/p62-targeted Small Molecules for Multiple Myeloma Disease

批准号：

9347881
项目类别：
资助金额：

$30.0万
财政年份：

2017
负责人：

James Lee
依托单位：

ID4PHARMA, LLC

Mapping the pathway of membrane β-barrel protein folding by the Bam complex.

批准号：

9249920
项目类别：
资助金额：

$3.19万
财政年份：

2016
负责人：

James Lee
依托单位：

HARVARD UNIVERSITY

Mapping the pathway of membrane β-barrel protein folding by the Bam complex.

批准号：

9120058
项目类别：
资助金额：

$3.14万
财政年份：

2016
负责人：

James Lee
依托单位：

HARVARD UNIVERSITY

海外基金