A pilot study to characterize brain dynamic biomarkers of fentanyl for opioid overdose monitoring

阿片类药物的流行是现代历史上最大的公共卫生危机之一。急救人员 室人员和药物过量观察单位遇到药物过量的病人下不同程度的 镇静和生理痛苦。药物作用的时间过程和逆转的剂量要求 考虑到阿片类药物的不同效力， 影响，以及个体吸毒者未知的药物敏感性。该项目的目标是描述 芬太尼在人体内的EEG特征及其与无意识和全身性状态的关系 physiology.我们建议在手术室的高度控制范围内这样做， 常规实施全身麻醉。在这样做的过程中，我们的目标是构建一个临床和定量的 芬太尼效应的神经生理学基础，可用于开发新的监测器，以改善对 阿片类药物过量的病人

The opioid epidemic is one of the largest public health crises in modern history. First-responders, emergency room personnel, and overdose observation units encounter drug overdose patients under varying degrees of sedation and physiological distress. The time course of drug effects, and the dosing requirements of reversal medications, can be difficult if not impossible to gauge, given the different potencies of opioids that could be in effect, and the unknown drug sensitivity of individual drug users. The goal of this project is to characterize the EEG signatures of fentanyl in humans, and their relationship with states of unconsciousness and systemic physiology. We propose to do so within the highly controlled confines of the operating room, where fentanyl is routinely administered general anesthesia. In doing so, we aim to construct a clinical and quantitative neurophysiological basis for fentanyl's effects that can be used to develop new monitors to improve care of opioid overdose patients.