A pilot study to characterize brain dynamic biomarkers of fentanyl for opioid overdose monitoring

一项表征芬太尼大脑动态生物标志物的初步研究，用于阿片类药物过量监测

• 批准号: 9894778
• 负责人: Patrick L. Purdon
• 金额: $ 21万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9894778
• 关键词: Absence of pain sensation; Accident and Emergency department; Accounting; Anesthesiology; Anesthetics; Arousal; Behavior; Behavioral; Biological Markers; Brain; Caring; Clinical; Distress; Dose; Drug Kinetics; Drug usage; Drug user; Electroencephalogram; Fentanyl; General Anesthesia; Goals; Human; Human Resources; Individual; Intervention; Intubation; Link; Measures; Modern 1601-history; Monitor; Operating Rooms; Opioid; Overdose; Patients; Pharmaceutical Preparations; Phase; Physicians; Physiological; Physiology; Pilot Projects; Public Health; Research; Respiration; Resuscitation; Savings; Sedation procedure; Signal Transduction; Structure; Time; Unconscious State; United States; Ventilatory Depression; clinical care; clinical decision support; clinical decision-making; clinical practice; cost; density; drug sensitivity; first responder; improved; individual patient; neural circuit; neurophysiology; nociceptive response; opioid epidemic; opioid overdose; pharmacodynamic model; respiratory; response; source localization; synthetic opioid; tool

The opioid epidemic is one of the largest public health crises in modern history. First-responders, emergency room personnel, and overdose observation units encounter drug overdose patients under varying degrees of sedation and physiological distress. The time course of drug effects, and the dosing requirements of reversal medications, can be difficult if not impossible to gauge, given the different potencies of opioids that could be in effect, and the unknown drug sensitivity of individual drug users. The goal of this project is to characterize the EEG signatures of fentanyl in humans, and their relationship with states of unconsciousness and systemic physiology. We propose to do so within the highly controlled confines of the operating room, where fentanyl is routinely administered general anesthesia. In doing so, we aim to construct a clinical and quantitative neurophysiological basis for fentanyl's effects that can be used to develop new monitors to improve care of opioid overdose patients.

阿片类药物流行是现代历史上最大的公共卫生危机之一。第一响应者，紧急情况 房间人员和过量观察单位在不同程度的情况下遇到药物过量患者 镇静和生理困扰。药物效应的时间过程以及反转的剂量要求 鉴于阿片类药物的不同效力，药物可能很难衡量 效果以及个别吸毒者的未知药物敏感性。该项目的目的是表征 芬太尼在人类中的脑电图及其与无意识和系统性状态的关系 生理。我们建议在手术室的高度控制范围内进行此操作，芬太尼在那里 常规进行全身麻醉。在这样做的过程中，我们旨在构建临床和定量 芬太尼作用的神经生理基础，可用于开发新的监测器以改善护理 阿片类药物过量患者。

项目成果

An electroencephalogram biomarker of fentanyl drug effects.

• DOI: 10.1093/pnasnexus/pgac158
• 发表时间: 2022-09
• 期刊: PNAS NEXUS
• 作者: Balanza, Gustavo A.;Bharadwaj, Kishore M.;Mullen, Andrew C.;Beck, Amanda M.;Work, Erin C.;McGovern, Francis J.;Houle, Timothy T.;Eric, T. Pierce;Purdon, Patrick L.
• 通讯作者: Purdon, Patrick L.