Preclinical Imaging Shared Facility

成像组 临床前影像共享设施(PCISF) 摘要 临床前影像共享设施(PCISF)满足了UAB-CCC的关键优先级，支持超过50 五个项目的成员，从事癌症检测和治疗评估的临床前影像研究。这个 设备提供对新的癌症治疗方法的详细成像评估，从而加速它们的翻译 去做人体试验。具体目标如下：(1)提供最先进的分子成像技术 在适当的动物模型中进行临床前研究，并支持IND过渡到人体成像研究；(2) 为CCC成员提供癌症模型分子成像方面的咨询和培训；(3)建立 图像分析方法；(4)维护和准确校准仪器；(5) 开发新的成像技术和获得新的仪器。该设施将协调现有的支持 UAB的成像机制，并通过临床相关成像显著扩展成像工作 这可以被翻译成人类。成像组件包括结构和代谢成像(MRI/MRS， 高频超声和微型CT)、伽马射线成像(伽马相机、微型SPECT/CT、 MicroPET/CT、PET/MR)和光学成像(生物发光和荧光)。PCISF已承诺 一种多模式成像方法在动物模型中提供对癌症的分子理解 整合肿瘤质量测量(生物发光、超声、CT和MR)、肿瘤特异性靶向 (SPECT、超声、荧光、微型PET)、血管参数(超声、MR)和特定治疗 反应(超声、生物发光、SPECT、MR、microoPET)。每种成像方式都有各自的优点和 它们的协同应用是协同的。该设施满足了评估新疗法的关键需求 动物模型中的癌症，从而使新的治疗方法能够转化为人体试验。该设施将 增强UAB-CCC共享设施的潜力(高分辨率成像、组织采购、 质谱学/蛋白质组学、转基因动物和人体成像) 活体动物中的分子途径，使精确的组织采样和微量分析成为可能，并促进 翻译成人体研究。

IMAGING GROUP PRECLINICAL IMAGING SHARED FACILITY (PCISF) ABSTRACT The Preclinical Imaging Shared Facility (PCISF) fulfills a critical UAB-CCC priority by supporting over 50 members in five programs with preclinical imaging studies for detection of cancer and therapy evaluation. The facility provides detailed imaging evaluation of new cancer treatments, and thereby accelerates their translation to human trials. The specific aims are the following: (1) to provide state-of-the-art molecular imaging for preclinical studies in appropriate animal models, and support IND's for transition to human imaging studies; (2) to provide consultation and training to CCC members for molecular imaging in cancer models; (3) to establish methods for image analyses; (4) to maintain the instruments and keep them accurately calibrated; and (5) to develop novel imaging technologies and acquire new instruments. The facility will coordinate existing support mechanisms for imaging at UAB, and significantly expand the imaging effort with clinically relevant imaging that can be translated to humans. Imaging components include structural and metabolic imaging (MRI/MRS, high frequency ultrasonography and microCT), gamma-ray imaging (gamma camera, microSPECT/CT, microPET/CT, PET/MR), and optical imaging (bioluminescence and fluorescence). The PCISF has undertaken a multimodality imaging approach to provide a molecular understanding of cancer in animal models by integrating measurements of tumor mass (bioluminescence, ultrasound, CT, and MR), tumor specific targeting (SPECT, ultrasound, fluorescence, microPET), vascular parameters (ultrasound, MR), and specific therapy responses (ultrasound, bioluminescence, SPECT, MR, micoPET). Each imaging modality has advantages and their coordinated application is synergistic. The facility meets a critical need in evaluation of new therapies for cancer in animal models, thereby enabling translation of the new therapies to human trials. The facility will enhance the potential of other UAB-CCC shared facilities (High Resolution Imaging, Tissue Procurement, Mass Spectrometry/Proteonomics, Transgenic Animal, and Human Imaging) by providing real-time imaging of molecular pathways in the living animal, enabling precise tissue sampling and microanalyses, and facilitating translation to human studies.