Core Grant for Vision Research

视觉研究核心资助

• 批准号: 9770863
• 负责人: BRET A HUGHES
• 金额: $ 59.15万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9770863
• 关键词: Basic Science; Biochemistry; Bioinformatics; Biometry; Clinical; Clinical Research; Collaborations; Complex; Computers; Core Grant; Data; Defect; Developmental Biology; Disease; Electronics; Electrophysiology (science); Engineering; Environment; Equipment; Evaluation; Fluorescence; Fostering; Goals; Grant; Human Resources; Image; Image Analysis; Immunology; Individual; Knowledge; Laboratories; Laboratory Animals; Light; Mechanics; Michigan; Microarray Analysis; Microscopy; Molecular Biology; Molecular Genetics; Morphology; Neurobiology; Ophthalmology; Productivity; Public Health; Research; Research Personnel; Resources; Scientist; Services; Structure; Technical Expertise; Universities; Ursidae Family; Vision; Vision research; Visual; Visual system structure; confocal imaging; cost; design and construction; eye center; instrument; instrumentation; interest; novel; ocular imaging; preservation; repaired; skills; square foot; therapeutic development; tissue processing; vision science

SUMMARY/ABSTRACT - OVERALL Continued support is sought for the Core Grant for Vision Research at the University of Michigan. Support for five Modules is requested: 1) an Electronics and Computer Module for designing and constructing novel electronic equipment, providing assistance with research computers and their interfaces with laboratory instruments, and repairing existing electronic equipment, staffed by an electronics engineer; 2) a Functional Assessment Module for the imaging of ocular structures and the evaluation of ocular function in living laboratory animals, staffed by a technician; 3) an Instrument Shop Module for designing and constructing mechanical instrumentation and modifying or repairing existing instrumentation, staffed by an instrument maker; 4) a Molecular Biology Module for providing access to instrumentation necessary for molecular biology as well assistance with the analysis of microarray and bioinformatics data, staffed by a statistical geneticist; and 5) a Morphology and Imaging Module for providing access to state-of-the-art equipment and expert personnel for ocular tissue processing, microscopy (light, wide-field fluorescence, and confocal), and image analysis, staffed by a technician. The specific aims of the Vision Research Core at the University of Michigan are to enhance the research environment for vision scientists, facilitate collaborative studies of the visual system and its diseases, and expand vision research on this campus to bring the skills and perspectives of non-vision scientists to bear upon research on the visual system. The 31 participating investigators currently hold 11 NEI R01 grants as well as 2 NEI K08 grants. The research interests of these investigators are diverse and include electrophysiology, neurobiology, biochemistry, molecular biology, molecular genetics, developmental biology, biostatistics, immunology, and clinical ophthalmology. The Vision Research Core is housed within the W.K. Kellogg Eye Center, a 300,000 sq. ft. building complex containing space dedicated to each of the modules, plus state-of-the-art facilities for basic and clinical research. The Department of Ophthalmology and Visual Sciences and the University of Michigan provide substantial additional resources that support the shared goal of fostering vision research.

摘要/摘要 - 总体 密歇根大学视觉研究核心拨款正在寻求持续支持。支持 需要五个模块：1）用于设计和构建新颖的电子和计算机模块 电子设备，为研究计算机及其与实验室的接口提供帮助 仪器，并维修现有的电子设备，由一名电子工程师组成； 2）函数式 用于眼结构成像和活体眼功能评估的评估模块 实验动物，配备一名技术人员； 3) 用于设计和构建的仪器车间模块 机械仪器和修改或修理现有仪器，配备仪器 制造商； 4) 分子生物学模块，用于提供分子生物学所需仪器的访问 以及由统计遗传学家协助分析微阵列和生物信息学数据； 5) 形态学和成像模块，用于提供最先进的设备和专家的访问 眼组织处理、显微镜（光、宽场荧光和共焦）和图像人员 分析，由一名技术人员负责。 密歇根大学视觉研究核心的具体目标是加强研究 为视觉科学家提供环境，促进视觉系统及其疾病的合作研究，以及 扩大该校园的视觉研究，以利用非视觉科学家的技能和观点 视觉系统研究。 31 名参与研究人员目前拥有 11 项 NEI R01 资助以及 2 项 NEI K08 资助。这 这些研究人员的研究兴趣多种多样，包括电生理学、神经生物学、生物化学、 分子生物学、分子遗传学、发育生物学、生物统计学、免疫学和临床 眼科。视觉研究核心位于 W.K.凯洛格眼科中心，占地 300,000 平方英尺。 建筑群包含每个模块专用的空间，以及用于基本功能的最先进的设施 和临床研究。眼科和视觉科学系和密歇根大学 提供大量额外资源，支持促进视觉研究的共同目标。