ShEEP Equipment Request for GeoMx™ Digital Spatial Profiler System

此应用程序将代表收购GeoMx™数字空间剖面仪系统(纳米线技术 旧金山退伍军人医疗中心(SFVAMC)骨骼生物学和生物力学核心设施的 最初成立于2003年，由BLR&D研究促进奖计划资助，后来 BR&D计划项目。该核心已经支持了70多个退伍军人管理局、国家卫生研究院和国防部资助的项目 内分泌学、整形外科、神经生物学、免疫学和心胸外科，并启用 在加州大学旧金山分校的基础研究和翻译研究方面进行了大量新的合作 社区。拟议收购这一最先进的GeoMx™数字空间剖面仪系统， 旨在进一步扩大我们的核心 翻译和临床研究能力。该工具将允许调查人员访问此核心 研究来自动物研究和组织的细胞、分子和生化特征 以高通量和高数量的方式对患者进行活检。鉴于分子的关键作用 在整个发育和疾病的生物过程中的变化(RNA和蛋白质表达)，这 设备将使我们的研究人员能够为现有研究提供便利，并继续探索未知的研究领域 其效率和精确度是核心区现有仪器无法达到的。这 新的仪器有望在短期内极大地扩大9种活动性VA的研究范围。 资助的项目和9多个国家卫生研究院和国防部的项目授予参与调查人员。

This application is to acquire a GeoMx™ Digital Spatial Profiler System (NanoString Technology) on behalf of the San Francisco VA Medical Center (SFVAMC) Skeletal Biology and Biomechanics Core Facility, which was originally established in 2003 by funding of BLR&D Research Enhancement Award Program and later a BLR&D Program Project. This Core had supported more than 70 VA, NIH, and DoD-funded projects in endocrinology, orthopedics surgery, neurobiology, immunology, and cardiothoracic surgery, and enabled numerous new collaborations in basic and translational research within the greater UCSF research community. The proposed acquisition of this state-of-the-art GeoMx™ Digital Spatial Profiler System, which is optimized to facilitate analyses of biological specimens and outcomes, is aimed to further expand our Core capacity for translational and clinical investigation. This tool will allow investigators accessing this Core to investigate the cellular, molecular, and biochemical features of cells and tissues from animal studies and patient biopsies in a high-throughput and highly quantitative manner. Given the critical role of the molecular changes (RNA and protein expression) in biological processes throughout development and disease, this equipment would allow our investigators to facilitate existing studies and pursue unexplored area of research with an efficiency and accuracy that could not be achieved by the current instrumentation in the Core. This new instrumentation is anticipated in the short term to greatly expand the research scope of 9 active VA- funded projects and more than 9 NIH and DoD projects awarded to the participating investigators.