Drug Releasing Microdiscs for Esophageal Drug Delivery

用于食管药物输送的药物释放微盘

• 批准号: 9903414
• 负责人: Rachel Chevalier
• 金额: $ 7.5万
• 依托单位: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9903414
• 关键词: Address; Adrenal Cortex Hormones; Affect; Alginates; Amino Acids; Area; Biological Availability; Biomedical Engineering; Budesonide; Child; Childhood; Chitosan; Chocolate; Clinical; Controlled Environment; Deglutition; Development; Disease; Disease Outcome; Dose; Drug Delivery Systems; Drug Targeting; Eosinophilic Esophagitis; Epithelial; Epithelium; Esophageal Stenosis; Esophagus; Excipients; Exhibits; Exposure to; FDA approved; Failure; Failure to Thrive; Film; Food Aversion; Force of Gravity; Formulation; Future; Gastroenterologist; Gastrointestinal tract structure; Goals; Healthcare; High Pressure Liquid Chromatography; Honey; Humidity; Individual; Industry; Infant formula; Inflammatory; Intestines; Knowledge; Lead; Length; Masks; Measures; Methodology; Methods; Microfabrication; Morbidity - disease rate; Mucous Membrane; Oral; Palate; Pathology; Patients; Pattern; Peristalsis; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacotherapy; Physicians; Physiological; Physiology; Polymers; Property; Saliva; Seaweed; Semiconductors; Shapes; Silicon; Site; Sodium; Steroids; Surface; Suspensions; Taste Perception; Techniques; Temperature; Therapeutic; Thinness; Time; Tissues; Toxic effect; Training; Work; base; biocompatible polymer; biomaterial compatibility; chronic inflammatory disease; clinical practice; controlled release; cost; design; effective therapy; fluticasone; improved; in vivo; manufacturing process; novel; novel therapeutics; off-label use; pediatric patients; residence; side effect; standard of care; success; targeted treatment; uptake

PROJECT SUMMARY: Eosinophilic esophagitis (EoE) is an inflammatory disease affecting children at an increasing rate leading to failure to thrive, esophageal stricturing, and the need for long term healthcare. Off-label use of topical steroids is the mainstay of treatment, but a high failure rate and clinical concerns of palatability have necessitated physicians using unstudied grocery items as excipients. The goal of this proposal is to investigate the properties of current empiric therapies and use that knowledge to develop a microscale polymer disc (microdiscs) designed to improve residence time of drug therapy in the esophagus. Microdiscs are designed to prolong drug residence time in the esophagus and have controlled-release properties to increase mucosal exposure to drug, thus delivering drug directly to the target site of EoE. The prolonged residence time of the mucoadhesive discs will be expected to improve bioavailability which decreases patient exposure to steroids, decreases costs, and opens new possibilities for other pharmaceutical treatments with fewer side effects to be delivered in the same manner.

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