Diabetes Prevention Culturally Tailored for Mexican Americans

为墨西哥裔美国人量身定制的糖尿病预防文化

• 批准号: 9908068
• 负责人: SHARON A BROWN
• 金额: $ 59.13万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9908068
• 关键词: Acculturation; Address; Adherence; Adopted; Area; Behavior; Behavior Therapy; Behavioral; Blood Pressure; Candidate Disease Gene; Caring; Clinical; Communities; Community Health Aides; Control Groups; County; Death Rate; Diabetes Mellitus; Diabetes prevention; Diagnosis; Dietary intake; Dietitian; Eating; Education; Educational Intervention; Effectiveness of Interventions; Enrollment; Ethnic group; Family member; Focus Groups; Food; Genetic Variation; Genetic study; Growth; Guidelines; Health; Health Services Accessibility; Health behavior; Healthy Eating; Hispanics; Hour; Hypertension; Impaired fasting glycaemia; Individual; Intervention; Laboratories; Left Ventricular Hypertrophy; Life Style; Lipids; Maintenance; Measures; Medical; Mexican Americans; Mexico; Minority; Modeling; Monitor; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Nurses; OGTT; Obesity; Outcome; Participant; Pharmaceutical Preparations; Pharmacology; Physical activity; Physicians; Pollution; Population; Population Programs; Poverty; Prediabetes syndrome; Prevalence; Preventive Intervention; Primary Prevention; Problem Solving; Public Health; Randomized; Resources; Rest; Risk; Rural; Side; Sleep Apnea Syndromes; Support Groups; Testing; Texas; Time; Translational Research; Unemployment; Ursidae Family; arm; authority; base; bilingualism; blood glucose regulation; comparison intervention; cost; demographics; deprivation; design; diabetes management; diabetes prevention program; diabetes risk; diabetes self-management; diabetic; effectiveness testing; endothelial dysfunction; exome sequencing; experimental group; good diet; health belief; healthy lifestyle; high risk; impaired glucose tolerance; improved; improved outcome; innovation; intervention effect; lifestyle intervention; medically underserved; motivational enhancement therapy; multilevel analysis; non-diabetic; prevent; primary outcome; programs; response; side effect; success; urban area; usual care arm; waist circumference; whole genome

ABSTRACT Starr County is a poor Texas-Mexico border community that is 98% Mexican American and has the highest diabetes-related death rate in Texas. In previous Starr County studies, we tested interventions culturally tailored for Spanish-speaking Mexican Americans diagnosed with type 2 diabetes (T2DM). Each study participant was supported by a family member who also received program benefits; 70% of these supporters did not have diabetes. Compared to the control group, fewer non-diabetic supporters in the experimental group converted to diabetes by 12 months post study entry. The primary purpose of the proposed study is to test the effectiveness of our culturally tailored DSME intervention that will be adapted for preventing, or at least delaying, diabetes onset in Mexican Americans with prediabetes. The intervention will involve: 1) 12 2- hour weekly group educational sessions that emphasize eating and preparing healthy Mexican-American foods and increasing physical activity; 2) 15 2-hour bi-weekly/monthly support group sessions on problem solving the barriers to adopting healthier lifestyles; and 3) 3 booster sessions held at 6-month intervals. We will integrate aspects of the Diabetes Prevention Program, as well as motivational interviewing, and prior to intervention testing, we will conduct focus groups with key individuals in Starr County to confirm the strategy and obtain community support. Intervention effectiveness will be examined using a randomized, repeated measures, pretest/posttest control group design, with an “enhanced” usual care control group. We will enroll 300 Mexican Americans with verified prediabetes from rosters of ongoing Starr County genetic studies. Groups of 10 will be constituted according to the area of the county in which people live; each group will be randomly assigned to experimental or control conditions. Growth curve analysis, using multilevel models, will be used to compare intervention effects on health outcomes over time. We hypothesize that participants in the experimental group, compared to the control group, will have better health outcomes (A1C, FBG, lipids, BP, physical activity, dietary intake, and anthropometric variables [BMI, waist circumference]) at 3, 6, 12, 24, and 36 months post baseline, as well as lower rates of converting to T2DM (OGTT) by 36 months. This study is a significant step in our plan to develop effective culturally tailored health programs for populations at high risk for T2DM.

摘要 斯塔尔县是一个贫穷的得克萨斯州和墨西哥边境社区，98%的墨西哥裔美国人， 得克萨斯州的糖尿病死亡率在以前的斯塔尔县研究中，我们测试了文化干预， 为诊断为2型糖尿病（T2 DM）的讲西班牙语的墨西哥裔美国人量身定制。每个研究 参与者得到一名家庭成员的支持，该家庭成员也获得了计划福利;这些支持者中有70% 没有糖尿病。与对照组相比， 组在研究入组后12个月转化为糖尿病。拟议研究的主要目的是 测试我们的文化量身定制的DSME干预措施的有效性，这些干预措施将适用于预防，或 最不延迟的是患有前驱糖尿病的墨西哥裔美国人的糖尿病发作。干预将涉及：1）12 2- 小时每周小组教育会议，强调饮食和准备健康的墨西哥裔美国人 食物和增加体力活动; 2）15个两周/每月两小时的问题支持小组会议 消除采用更健康生活方式的障碍; 3）每隔6个月举行3次强化会议。我们 将整合糖尿病预防计划的各个方面，以及动机访谈，并在此之前， 干预测试，我们将与斯塔尔县的关键人物进行焦点小组，以确认该策略 并获得社区支持。干预有效性将使用随机、重复 措施，前测/后测控制组设计，与“增强”的日常护理控制组。我们将招收 从正在进行的斯塔尔县遗传学研究的名册中确定了300名患有糖尿病前期的墨西哥裔美国人。 10人一组将根据人们居住的县的面积组成;每组将 随机分配到实验或对照条件。使用多水平模型的增长曲线分析将 用于比较干预措施对健康结果的长期影响。我们假设参与者 与对照组相比，实验组将具有更好的健康结果（A1 C，FBG，脂质， 血压，体力活动，饮食摄入量和人体测量变量[BMI，腰围]），在3，6，12，24， 基线后36个月，以及36个月时转化为T2 DM（OGTT）的比率较低。本研究 这是我们计划为高收入人群制定有效的文化定制健康计划的重要一步。 T2 DM的风险。