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Molecular Epidemiology of Oxidative Stress and Related Cancers in Black Women

黑人女性氧化应激及相关癌症的分子流行病学

基本信息

批准号：
9906186
负责人：
Chiranjeev Dash
金额：
$ 13.08万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-09 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9906186
关键词：
3-nitrotyrosine 8-hydroxy-2&apos -deoxyguanosine Address African American Antioxidants Area Award Bioinformatics Biological Assay Biological Markers Biometry Breast Cancer Risk Factor Cancer Etiology Chronic Cohort Studies Colorectal Cancer Colorectal Neoplasms Complement Complex Cysteine DNA Data Data Analyses Development Diet Dietary Practices Dietary intake District of Columbia Epidemiology Equilibrium Etiology F2-Isoprostanes Failure Food Frequencies Glutathione Glutathione Disulfide Goals Individual Investigation K-Series Research Career Programs Lipids Macronutrients Nutrition Malignant Neoplasms Mammary Neoplasms Measurement Measures Mediating Mentorship Metabolic Methods Micronutrients Minority Minority Groups Modeling Molecular Epidemiology Molecular Epidemiology of Cancer National Cancer Institute Nitrogen Observational Study Oxidation-Reduction Oxidative Stress Oxygen Participant Pathogenesis Patient Self-Report Pattern Phase Population Population Study Positioning Attribute Prevention Process Prospective cohort study Proteins Proteomics Questionnaires Reactive Oxygen Species Reporting Research Research Personnel Research Training Risk Role Sampling Sum Systems Biology Technology Tissues Training Translational Research Variant Woman Women&apos s Health anticancer research base biomarker panel cancer chemoprevention cancer health disparity cancer initiation cancer prevention cancer risk carbonyl group carcinogenesis career cohort colon cancer risk cost design dietary antioxidant epidemiology study experience health disparity high risk human old age (65+)in vivo malignant breast neoplasm metabolomics metropolitan minority health nutritional epidemiology oxidation phase 2 study population based portability public health relevance recruit sample collection skills true biomarker tumor progression underserved minority

项目摘要

DESCRIPTION (provided by applicant): Oxidative stress is defined as an "imbalance in pro-oxidants and antioxidants with associated disruption of redox circuitry and macromolecular damage". Chronic oxidative stress is believed to increase the risk of many cancers such as breast and colorectal cancers. Despite being at increased risk of developing and dying from oxidative-stress related cancers, African-Americans are under-represented in population-based studies of oxidative stress and cancer. This is especially true for biomarker-based and nutritional epidemiology studies of oxidative stress. This career development award is designed to provide training and research experience to Dr. Dash to support his goal of becoming an independent researcher investigating the molecular epidemiology of cancers among minorities including cancer disparities. Proposed training plans include mentorship and coursework in proteomics, metabolomics, bioinformatics, and exploratory data analysis, filling gaps in research training related to studies among minorities and health disparity studies, and research considerations in recruitment and bio specimen collection from minorities in epidemiologic research. The research component of the proposal aims to address the research gaps mentioned above by (1) characterizing the systemic oxidative stress burden via measurement of a panel of known biomarkers of oxidative stress using proteomics and metabolomics technologies; (2) identifying dietary patterns associated with oxidative stress; and (3) investigating the association of these dietary patterns with risk of breast and colorectal cancers among African- American women. The study will be conducted in two phases. Phase 1 involves measurement of a panel of 6 oxidative stress biomarkers using proteomic and metabolomic approaches and describing the oxidative stress burden among African-American women without cancer. Dietary patterns related to the biomarkers of oxidative stress will also be identified usin dietary intake data self-reported by participants on food frequency questionnaires. Phase 2 of the study involves investigating the association of the oxidative stress-related dietary patterns developed in Phase 1 with breast and colon cancer risk in a large, nationally-representative, cohort study of Black women. Results from the study will support larger and more definitive studies on oxidative stress and cancer among African-American women. The proposed research complements the training and mentorship plans in proteomics, metabolomics, bioinformatics, biostatistics, and minority health research. With this award Dr. Chiranjeev Dash will combine his previous training in epidemiology with advanced training in metabolomics/proteomics, bioinformatics, and biostatistics, and gain experience in conduct of minority health research to establish an independent research career focusing on translational research on the molecular epidemiology of oxidative stress in cancer causation and prevention.