Developmental Center for Human Urinary Bladder Myogenic Mechanisms by Ion Channels in Health and Disease

健康和疾病中离子通道的人类膀胱生肌机制发展中心

• 批准号: 9912570
• 负责人: Georgi V Petkov
• 金额: $ 30.4万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-18 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912570
• 关键词: Advisory Committees; Applications Grants; Basic Science; Benign; Biochemistry; Bladder; Bladder Dysfunction; Cells; Clinical; Collaborations; Committee Members; Communication; Community Outreach; Development; Disease; Education and Outreach; Educational workshop; Electrophysiology (science); Etiology; Faculty; Functional disorder; Goals; Grant; Health; Health Sciences; Human; Impairment; Intention; Interdisciplinary Study; Ion Channel; Medicine; Mission; Molecular; Nursing Faculty; Overactive Bladder; Pathologic; Patients; Pharmacology; Pharmacy facility; Physiology; Play; Quality of life; Research; Research Personnel; Research Project Grants; Role; Signal Transduction; Smooth Muscle; Structure; Techniques; Tennessee; Therapeutic; Time; Tissues; Treatment Efficacy; United States National Institutes of Health; Universities; Urology; Whole Organism; base; college; design; drug discovery; improved; in vivo; interdisciplinary approach; meetings; member; multidisciplinary; new therapeutic target; novel; novel strategies; novel therapeutic intervention; programs; urologic; web site

ABSTRACT DC-HUB DEVELOPMENTAL CENTER The intention of this P20 planning grant application is to establish the “Developmental Center for Human Urinary Bladder Myogenic Mechanisms by Ion Channels in Health and Disease” (DC-HUB), focused on investigating the role of ion channels in benign urology. Ion channels play important roles in urinary bladder function, but much remains to be discovered. The objective of this DC-HUB planning grant is to organize a multidisciplinary collaborative program at the University of Tennessee Health Science Center (UTHSC). The goal of this multidisciplinary collaborative program is to examine the roles of ion channels and their regulatory mechanisms in the human urinary bladder under normal and benign pathological conditions. The program will investigate the molecular, cellular, tissue, and whole organism (in vivo) mechanisms by which ion channels regulate urinary bladder function and dysfunction, leading to identification of novel pharmacological targets for benign urological indications. Our collaborative DC-HUB will consist of investigators with demonstrated expertise in basic and clinical urology, physiology, pharmacology, electrophysiology, drug discovery, biochemistry, and signal transduction. Employing a rigorous interdisciplinary approach, using state-of-the-art techniques, we will determine the roles of ion channels and their regulatory mechanisms in urinary bladder function from molecules and isolated cells to intact tissues and whole organisms. Our long-term goal is to establish an effective multidisciplinary program to develop novel strategies for safe and effective therapeutic control of overactive bladder (OAB). This DC-HUB proposal is a result of extensive collaboration among basic science and clinical faculty at UTHSC from Colleges of Pharmacy and Medicine. Our partnership for excellence in research, education, and community outreach is grounded on complementary strengths, mutual respect, and a genuine passion to create a new Research Center focused on the role of ion channels in benign urology. By the end of this P20 planning grant period, we will develop a coherent theme and strategy for our interdisciplinary collaborative research program and establish interactive and collaborative research projects, each with working hypotheses and aims fully developed at the submission of an NIH U54-level or P01-level grant application. Our multidisciplinary research team involving UTHSC faculty and outside collaborators perfectly matches the description criteria for this current NIH P20 RFA-DK-18-028 solicitation. Therefore, there is a high likelihood for this integrative effort to grow into an NIH U54-level, multi-PI R01, or P01-level grant.

摘要DC-HUB开发中心 P20计划赠款申请的目的是建立“人类尿液发展中心 离子通道健康和疾病中的膀胱肌源性机制”（DC-HUB），重点是研究 离子通道在良性泌尿外科中的作用。离子通道在尿中膀胱功能中起重要作用，但很多 还有待发现。该DC-HUB计划赠款的目的是组织一个多学科 田纳西大学健康科学中心（UTHSC）的合作计划。目标的目标 多学科协作计划是检查离子渠道及其监管机制的作用 在正常和良性病理状况下的人类尿中膀胱中。该计划将调查 分子，细胞，组织和整个生物体（体内）机制，通过该机制，离子通道调节尿液 膀胱功能和功能障碍，导致鉴定新的药物泌尿外科靶标 适应症。我们的协作DC-HUB将由研究人员组成，具有基本和基本方面的专业知识 临床泌尿外科，生理学，药理学，电生理学，药物发现，生物化学和信号 转导。采用严格的跨学科方法，使用最先进的技术，我们将 确定离子通道及其调节机制在分子中的泌尿膀胱功能中的作用 以及分离的细胞到完整的组织和整个生物体。我们的长期目标是建立有效的 多学科计划，以制定新型策略，以安全有效地控制过度活跃 膀胱（OAB）。该DC-HUB建议是基础科学和临床之间广泛合作的结果 UTHSC学院的药学和医学学院。我们的卓越研究合作伙伴关系， 教育和社区宣传是基于完整的优势，相互尊重和真正的 热情创建一个新的研究中心，重点是离子渠道在良性泌尿外科中的作用。到结束 在P20计划赠款期间，我们将为我们的跨学科制定一个连贯的主题和策略 协作研究计划并建立互动和协作研究项目，每个研究项目 假设和目标是在提交NIH U54级或P01级授予申请的情况下完全开发的。我们的 多学科研究团队涉及UTHSC教师和外部合作者，与 描述当前NIH P20 RFA-DK-18-028招标的标准。因此，很有可能 这项集成的努力将成长为NIH U54级，多PI R01或P01级授予。