Developmental Center for Human Urinary Bladder Myogenic Mechanisms by Ion Channels in Health and Disease

健康和疾病中离子通道的人类膀胱生肌机制发展中心

• 批准号: 9912570
• 负责人: Georgi V Petkov
• 金额: $ 30.4万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-18 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912570
• 关键词: Advisory Committees; Applications Grants; Basic Science; Benign; Biochemistry; Bladder; Bladder Dysfunction; Cells; Clinical; Collaborations; Committee Members; Communication; Community Outreach; Development; Disease; Education and Outreach; Educational workshop; Electrophysiology (science); Etiology; Faculty; Functional disorder; Goals; Grant; Health; Health Sciences; Human; Impairment; Intention; Interdisciplinary Study; Ion Channel; Medicine; Mission; Molecular; Nursing Faculty; Overactive Bladder; Pathologic; Patients; Pharmacology; Pharmacy facility; Physiology; Play; Quality of life; Research; Research Personnel; Research Project Grants; Role; Signal Transduction; Smooth Muscle; Structure; Techniques; Tennessee; Therapeutic; Time; Tissues; Treatment Efficacy; United States National Institutes of Health; Universities; Urology; Whole Organism; base; college; design; drug discovery; improved; in vivo; interdisciplinary approach; meetings; member; multidisciplinary; new therapeutic target; novel; novel strategies; novel therapeutic intervention; programs; urologic; web site

ABSTRACT DC-HUB DEVELOPMENTAL CENTER The intention of this P20 planning grant application is to establish the “Developmental Center for Human Urinary Bladder Myogenic Mechanisms by Ion Channels in Health and Disease” (DC-HUB), focused on investigating the role of ion channels in benign urology. Ion channels play important roles in urinary bladder function, but much remains to be discovered. The objective of this DC-HUB planning grant is to organize a multidisciplinary collaborative program at the University of Tennessee Health Science Center (UTHSC). The goal of this multidisciplinary collaborative program is to examine the roles of ion channels and their regulatory mechanisms in the human urinary bladder under normal and benign pathological conditions. The program will investigate the molecular, cellular, tissue, and whole organism (in vivo) mechanisms by which ion channels regulate urinary bladder function and dysfunction, leading to identification of novel pharmacological targets for benign urological indications. Our collaborative DC-HUB will consist of investigators with demonstrated expertise in basic and clinical urology, physiology, pharmacology, electrophysiology, drug discovery, biochemistry, and signal transduction. Employing a rigorous interdisciplinary approach, using state-of-the-art techniques, we will determine the roles of ion channels and their regulatory mechanisms in urinary bladder function from molecules and isolated cells to intact tissues and whole organisms. Our long-term goal is to establish an effective multidisciplinary program to develop novel strategies for safe and effective therapeutic control of overactive bladder (OAB). This DC-HUB proposal is a result of extensive collaboration among basic science and clinical faculty at UTHSC from Colleges of Pharmacy and Medicine. Our partnership for excellence in research, education, and community outreach is grounded on complementary strengths, mutual respect, and a genuine passion to create a new Research Center focused on the role of ion channels in benign urology. By the end of this P20 planning grant period, we will develop a coherent theme and strategy for our interdisciplinary collaborative research program and establish interactive and collaborative research projects, each with working hypotheses and aims fully developed at the submission of an NIH U54-level or P01-level grant application. Our multidisciplinary research team involving UTHSC faculty and outside collaborators perfectly matches the description criteria for this current NIH P20 RFA-DK-18-028 solicitation. Therefore, there is a high likelihood for this integrative effort to grow into an NIH U54-level, multi-PI R01, or P01-level grant.

摘要 DC-HUB 开发中心 本次P20规划拨款申请的目的是建立“人类泌尿系统发展中心” 健康和疾病中离子通道的膀胱生肌机制”（DC-HUB），重点研究 离子通道在良性泌尿外科中的作用。离子通道在膀胱功能中发挥着重要作用，但 仍有待发现。 DC-HUB 规划拨款的目标是组织一个多学科的项目 田纳西大学健康科学中心 (UTHSC) 的合作项目。此举的目标 多学科合作项目旨在研究离子通道的作用及其调节机制 在正常和良性病理条件下的人类膀胱中。该计划将调查 离子通道调节尿的分子、细胞、组织和整个有机体（体内）机制 膀胱功能和功能障碍，从而确定良性泌尿外科的新药理学靶点 迹象。我们的合作 DC-HUB 将由在基础和研究领域具有丰富专业知识的研究人员组成 临床泌尿学、生理学、药理学、电生理学、药物发现、生物化学和信号 转导。采用严格的跨学科方法，使用最先进的技术，我们将 从分子角度确定离子通道在膀胱功能中的作用及其调节机制 并将细胞分离成完整的组织和整个生物体。我们的长期目标是建立一个有效的 多学科计划，开发新策略，安全有效地控制过度活跃的治疗 膀胱（OAB）。该 DC-HUB 提案是基础科学和临床广泛合作的结果 UTHSC 药学院和医学院的教师。我们在研究领域的卓越合作， 教育和社区外展的基础是优势互补、相互尊重和真正的 热衷于创建一个新的研究中心，专注于离子通道在良性泌尿外科中的作用。到年底 在这个 P20 规划资助期内，我们将为我们的跨学科制定一个连贯的主题和战略 合作研究计划并建立互动和合作研究项目，每个项目都有工作 假设和目标在提交 NIH U54 级或 P01 级拨款申请时得到充分发展。我们的 由UTHSC教师和外部合作者组成的多学科研究团队完美匹配 当前 NIH P20 RFA-DK-18-028 征集的描述标准。因此，很有可能 这种综合努力成长为 NIH U54 级、多 PI R01 或 P01 级资助。