NONHUMAN PRIMATE CORE HUMORAL IMMUNOLOGY LABORATORY FOR AIDS VACCINE RESEARCH AND DEVELOPMENT

国家过敏和传染病研究所（NIAID）艾滋病司（DAIDS）的使命是通过支持可导致开发治疗方法、疫苗和预防战略的研究，确保结束人类免疫缺陷病毒/获得性免疫缺陷综合症（艾滋病毒/艾滋病）的流行。非人灵长类动物（NHP）模型提供了测试各种候选艾滋病疫苗的机会，优化其引发免疫反应的能力，并测试其预防感染或在病毒攻击后控制病毒复制的能力。DAIDS为NHP研究提供免疫学和病毒学支持，这些研究在NIAID的类人猿疫苗评估单位（SVEU）合同地点进行，艾滋病疫苗研究人员通过三个非人类灵长类动物免疫学和病毒学实验室进行艾滋病疫苗研究和开发（NHP核心实验室）合同。这些核心实验室的目标是确保临床前NHP研究检测的标准化和可比性，并为评估候选HIV和SIV疫苗的免疫原性和有效性提供一个共同的基础。

The mission of the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID) is to ensure an end to the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic by supporting research that can lead to the development of therapies, vaccines, and prevention strategies. Nonhuman primate (NHP) models present the opportunity to test a variety of candidate AIDS vaccines, optimizing their ability to elicit immune responses and testing their ability to prevent infection or to control virus replication after virus challenge. DAIDS provides immunological and virological support for NHP studies conducted at NIAID’s Simian Vaccine Evaluation Unit (SVEU) contract sites and by AIDS vaccine researchers through three Nonhuman Primate Immunology and Virology Laboratories for AIDS Vaccine Research and Development (NHP Core Labs) contracts. The objective of these Core Laboratories has been to ensure standardization and comparability of the assays conducted for preclinical NHP studies and to provide a common basis for assessment of the immunogenicity and efficacy of candidate HIV and SIV vaccines.