NONHUMAN PRIMATE CORE HUMORAL IMMUNOLOGY LABORATORY FOR AIDS VACCINE RESEARCH AND DEVELOPMENT

非人灵长类艾滋病疫苗研发核心体液免疫实验室

• 批准号: 9915634
• 负责人: DAVID MONTEFIORI
• 金额: $ 236.51万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-30 至 2020-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915634
• 关键词: AIDS Vaccines; Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Biological Assay; Contractor; Contracts; Detection; Ensure; Epidemic; HIV; HIV vaccine; HIV/SIV vaccine; Immune response; Immunization; Immunize; Immunologic Tests; Immunologics; Immunology; Infection; Infection prevention; Laboratories; Lead; Mission; Modeling; National Institute of Allergy and Infectious Disease; Prevention strategy; Reproducibility; Research Personnel; Research Support; SIV; SIV Vaccines; Site; Standardization; Testing; United States National Institutes of Health; Vaccine Research; Vaccines; Virus; Virus Replication; immunogenicity; improved; neutralizing antibody; nonhuman primate; pre-clinical; research and development; simian human immunodeficiency virus; therapy development; vaccine evaluation; virology

The mission of the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID) is to ensure an end to the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic by supporting research that can lead to the development of therapies, vaccines, and prevention strategies. Nonhuman primate (NHP) models present the opportunity to test a variety of candidate AIDS vaccines, optimizing their ability to elicit immune responses and testing their ability to prevent infection or to control virus replication after virus challenge. DAIDS provides immunological and virological support for NHP studies conducted at NIAID’s Simian Vaccine Evaluation Unit (SVEU) contract sites and by AIDS vaccine researchers through three Nonhuman Primate Immunology and Virology Laboratories for AIDS Vaccine Research and Development (NHP Core Labs) contracts. The objective of these Core Laboratories has been to ensure standardization and comparability of the assays conducted for preclinical NHP studies and to provide a common basis for assessment of the immunogenicity and efficacy of candidate HIV and SIV vaccines.

艾滋病司（DAIDS），国家过敏和传染病研究所（NIAID）的使命是确保结束人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）的流行病，通过支持可以导致疗法，疫苗，疫苗，疫苗和预测策略的研究，以支持研究。非人类灵长类动物（NHP）模型提供了测试各种候选艾滋病疫苗的机会，优化了它们引起免疫反应的能力，并测试了他们预防感染或控制病毒挑战后病毒复制的能力。 DAIDS通过三个非人类灵长类动物免疫学和艾滋病病毒学实验室（NHP Core Labs）合同，为NIAID的NIAID疫苗评估单位（SVEU）合同站点以及艾滋病疫苗研究人员提供免疫学和病毒学支持。这些核心实验室的目的是确保对临床前NHP研究进行评估的标准化和可比性，并为评估候选HIV和SIV疫苗的免疫原性和效率的共同基础。