Zebrafish Biomedical Research Facility Core

项目摘要-斑马鱼生物医学研究(ZBR)设施 堆芯 俄亥俄州立大学环境健康科学核心中心(EHS CC)开发了一种新的、集成的方法来 阐述NIEHS战略计划的主要内容。环境健康科学界是 越来越意识到水生模型可以提供的价值，以识别化学危险和 剖析影响疾病的分子途径。在过去的10年里，随着大量的EHS CC，NIEHS， 和机构投资，斑马鱼生物医学研究(ZBR)设施核心开创了 斑马鱼模型是发现和翻译研究的理想脊椎动物平台。ZBR已经创建了 世界上最大的斑马鱼毒性设施之一。我们可以评估对化学物质、纳米颗粒和 每年在300多万只动物中混合。我们经营着世界上唯一经过认证的不含特定病原体的 设施。我们开发了创新的软件和仪器，使我们能够识别生物活性 并确定不良后果的途径。我们的研究使研究人员能够优先考虑化学品 对于哺乳动物和流行病学研究，它们提供了一条通往生物标记物和治疗的途径 发现号。我们将ZBR作为一个全方位的设施，为EHS CC调查员和 利益相关者。我们的中心目标是消除技术和知识障碍，以便他们能够推进其 利用斑马鱼的独特优势进行研究。ZBR与 化学暴露核心(CXC)和综合健康科学设施核心(IHSFC)和社区 参与核心(CEC)，以推进EHS研究。ZBR将具体1)帮助EHS CC调查人员 了解非政府组织开展环境健康科学研究的优势和局限性 人体模型；2)为短期和长期提供技术核心支持和无特定病原体的斑马鱼 研究；3)提供前所未有的高通量研究平台，以评估毒性并确定 毒性机制。

PROJECT SUMMARY – Zebrafish Biomedical Research (ZBR) Facility Core The OSU Environmental Health Sciences Core Center (EHS CC), has developed a new, integrated approach to address major elements of the NIEHS strategic plan. The environmental health sciences community is becoming increasingly aware of the value that aquatic models can provide to identify chemical hazards and to dissect the molecular pathways that influence disease. Over the last 10 years, with substantial EHS CC, NIEHS, and Institutional investments, the Zebrafish Biomedical Research (ZBR) Facility Core has pioneered the zebrafish model as an ideal vertebrate platform for discovery and translational research. The ZBR has created one of the world's largest zebrafish toxicity facilities. We can assess responses to chemicals, nanoparticles, and mixtures in over 3,000,000 animals annually. We operate the world's only certified specific pathogen-free facility. We have developed innovative software and instrumentation that enable us to identify bioactive compounds and to identify adverse outcome pathways. Our studies enable investigators to prioritize chemicals for mammalian and epidemiological studies, and they provide a path toward biomarker and therapeutic discovery. We operate the ZBR as a full-service facility for a dynamic cadre of EHS CC investigators and stakeholders. Our central goal is to remove the technical and knowledge barriers so they can advance their research programs by exploiting the unique advantages of zebrafish. The ZBR interfaces seamlessly with the Chemical Exposure Core (CXC) and the Integrated Health Sciences Facility Core (IHSFC) and the Community Engagement Core (CEC) to advance EHS research. The ZBR will specifically 1) help EHS CC investigators understand the advantages and limitations of conducting environmental health sciences research with non- human models; 2) provide technical core support and specific-pathogen-free zebrafish for short- and long-term studies; 3) provide unprecedented high-throughput research platforms to evaluate toxicity and to determine toxicity mechanisms.