Leveraging Social Networks to Improve Uptake of a Novel Biomedical HIV Prevention Method

项目摘要 暴露前预防（PrEP），作为一种每日一次的药丸，代表了一种有效的生物医学艾滋病毒形式 预防与男性发生性关系的男性（MSM），但其在非洲裔美国人MSM中的使用仍然不理想 而相对于白色MSM而言则较低。非裔美国人MSM更有可能报告次优的依从性， 因此，使用长效注射（LAI）抗逆转录病毒药物 制剂作为PrEP可能是一个有吸引力的替代MSM感兴趣的生物医学艾滋病毒预防，但谁 可能难以每天服药然而，人们对哪些因素可能影响意愿知之甚少 在非裔美国人MSM中使用LAI-PrEP。拟议的研究将利用N2的现有数据 研究，一项基于人群的纵向队列的年轻艾滋病毒阴性的非洲裔美国男男性接触者居住在 芝加哥南区（n = 350）。利用非洲青年社会和性网络的详细信息， 美国男男性接触者，我们将评估一个人使用LAI-PrEP的意愿是否受到他们在 他们的网络。使用一种称为基于代理的建模的复杂系统方法，我们将模拟艾滋病毒 在年轻的非洲裔美国人MSM的动态网络中传播，使我们能够评估潜在的影响， 在改善LAI-PrEP使用和降低艾滋病毒发病率方面，标识所述社交 与未来使用LAI-PrEP相关的动态可能会对未来的成功产生重大影响。 预防方法以及非洲年轻人采用有效的LAI-PrEP制剂的速度 美国msm在实现我们的目标时，拟议研究的结果可用于优化 通过创新的基于网络的干预措施吸收LAI-PrEP，可能最大限度地提高其能力， 对美国艾滋病流行的持续影响。

PROJECT SUMMARY Pre-exposure prophylaxis (PrEP), formulated as a once-daily pill, represents an effective form of biomedical HIV prevention for men who have sex with men (MSM), but its use among African American MSM remains suboptimal and low relative to White MSM. African American MSM are more likely to report suboptimal adherence and subsequently seroconvert while using PrEP. As such, the use of long-acting injectable (LAI) antiretroviral drug formulations as PrEP may be an attractive alternative for MSM interested in biomedical HIV prevention but who may have difficulties with daily pill-taking. However, little is known about what factors may influence willingness to use LAI-PrEP among African American MSM. The proposed research will leverage existing data from the N2 Study, a population-based longitudinal cohort of young HIV-negative African American MSM residing on the South Side of Chicago (n = 350). Using detailed information on the social and sexual networks of young African American MSM, we will assess whether one’s willingness to use LAI-PrEP is impacted by their position within their networks. Using a complex systems approach known as agent-based modeling, we will simulate HIV transmission in the dynamic networks of young African American MSM, allowing us to assess the potential effects of a network-based intervention in improving LAI-PrEP use and reducing HIV incidence. Identifying the social dynamics associated with future use of LAI-PrEP may make a significant impact on the future success of this prevention method and the speed at which an effective LAI-PrEP formulation is taken up among young African American MSM. In achieving our aims, the findings from the proposed research may be used to optimize the uptake of LAI-PrEP through innovative network-based interventions, potentially maximizing its ability to make a sustained impact on the HIV epidemic in the United States.