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Development of novel therapy for hypokalemic periodic paralysis

Development of novel therapy for hypokalemic periodic paralysis
低钾性周期性麻痹新疗法的开发
批准号：
9926525
负责人：
MARK M RICH
金额：
$5.15万
依托单位：
WRIGHT STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
已结题
起止时间：
2019-07-01 至 2022-03-31
来源：
https://reporter.nih.gov/project-details/9926525
关键词：
Action PotentialsAfrican AmericanCarbonic Anhydrase InhibitorsCuriositiesDataDevelopmentDiseaseDoseDropsEnsureExposure toFDA approvedFunctional disorderFundingFutureGenerationsHourHyperkalemic periodic paralysisHypokalemiaHypokalemic periodic paralysisInheritedIon ChannelLeadLifeMeasuresMembrane PotentialsMentorsMuscleMuscle WeaknessMutateMutationMyopathyMyotonia CongenitaNational Institute of Arthritis and Musculoskeletal and Skin DiseasesParalysedParentsPathologicPatientsPeriodicityPharmaceutical PreparationsPhiladelphiaPlayResearch PersonnelResourcesRoleScienceTestingTranslational ResearchViolenceWalkersWorkchannel blockersexperimental studyextracellularimprovedinner citymanmouse modelmuscle stiffnessnovelnovel strategiesnovel therapeuticsparent grantperiodic paralysispreservationpreventskillsstandard of caresuccesstraffickingyoung man

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中文摘要
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英文摘要
It is generally thought that muscle excitability is controlled by only a few types of ion channels. We propose this understanding is incomplete and misses important ion channel types that regulate excitability during repetitive firing, but do not participate in a major way in firing of single action potentials. Since these currents are small, they are hard to identify and have been missed. In this proposal we will test the hypothesis that a novel current we discovered in muscle during studies of myotonia congenita and hyperkalemic periodic paralysis also plays a central role in triggering attacks of weakness in hypokalemic periodic paralysis. If successful this work has the potential to lead to improved therapy for patients.
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Novel Approaches to Therapy of Muscle Ion Channelopathies
  • 批准号：
    10398427
  • 项目类别：
  • 资助金额：
    $6.28万
  • 财政年份：
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  • 负责人：
    MARK M RICH
  • 依托单位：
    WRIGHT STATE UNIVERSITY
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    10400916
  • 项目类别：
  • 资助金额：
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  • 财政年份：
    2019
  • 负责人：
    MARK M RICH
  • 依托单位：
    WRIGHT STATE UNIVERSITY
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  • 批准号：
    9895630
  • 项目类别：
  • 资助金额：
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  • 财政年份：
    2019
  • 负责人：
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  • 依托单位：
    WRIGHT STATE UNIVERSITY
Reduced Motoneuron Excitability in Sepsis
  • 批准号：
    9309088
  • 项目类别：
  • 资助金额：
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  • 财政年份：
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  • 依托单位：
    WRIGHT STATE UNIVERSITY
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