Skeletal Muscle Stem Cells Derived from Teratomas

来自畸胎瘤的骨骼肌干细胞

基本信息

  • 批准号:
    9919497
  • 负责人:
  • 金额:
    $ 43.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-05-01 至 2024-04-30
  • 项目状态:
    已结题

项目摘要

Abstract Pluripotent stem cells hold tremendous promise for the eventual development of cell therapies for muscle disease; however it has proven exceptionally difficult to derive cells with meaningful in vivo regeneration potential from unmodified wild type (WT) pluripotent stem cells. Mouse transplantation studies with WT PSC- derived cells are rare, and success in the field currently equates to generation of a few hundred fibers in a transplanted tibialis anterior muscle with 3-4,000 total fibers. We have recently discovered that when mouse PSCs are differentiated into teratomas in vivo, they generate large numbers of skeletal muscle stem cells, and these cells have tremendous in vivo functional potential, regenerating the great majority of the TA muscle with force-generating muscle fibers upon transplantation. We propose a series of studies aimed at understanding how these cells arise, what makes them unique, translating these findings to the human system, and using this knowledge to improve in vitro differentiation protocols.
摘要

项目成果

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Michael Kyba其他文献

Michael Kyba的其他文献

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{{ truncateString('Michael Kyba', 18)}}的其他基金

Systemic Transplantation of MyoPAXon: IND Enabling Studies for the Treatment of DMD
MyoPAXon 的系统移植:治疗 DMD 的 IND 启用研究
  • 批准号:
    10822639
  • 财政年份:
    2023
  • 资助金额:
    $ 43.05万
  • 项目类别:
Dissecting Effects of Estrogen Deficiency on Satellite Cells and Muscle Regeneration in Females and Males
剖析雌激素缺乏对女性和男性卫星细胞和肌肉再生的影响
  • 批准号:
    9895295
  • 财政年份:
    2019
  • 资助金额:
    $ 43.05万
  • 项目类别:
Skeletal Muscle Stem Cells Derived from Teratomas
源自畸胎瘤的骨骼肌干细胞
  • 批准号:
    10403612
  • 财政年份:
    2019
  • 资助金额:
    $ 43.05万
  • 项目类别:
Skeletal Muscle Stem Cells Derived from Teratomas
来自畸胎瘤的骨骼肌干细胞
  • 批准号:
    9763683
  • 财政年份:
    2019
  • 资助金额:
    $ 43.05万
  • 项目类别:
Dissecting Effects of Estrogen Deficiency on Satellite Cells and Muscle Regeneration in Females and Males
剖析雌激素缺乏对女性和男性卫星细胞和肌肉再生的影响
  • 批准号:
    10417168
  • 财政年份:
    2019
  • 资助金额:
    $ 43.05万
  • 项目类别:
Skeletal Muscle Stem Cells Derived from Teratomas
源自畸胎瘤的骨骼肌干细胞
  • 批准号:
    10152519
  • 财政年份:
    2019
  • 资助金额:
    $ 43.05万
  • 项目类别:
Dissecting Effects of Estrogen Deficiency on Satellite Cells and Muscle Regeneration in Females and Males
剖析雌激素缺乏对女性和男性卫星细胞和肌肉再生的影响
  • 批准号:
    10023252
  • 财政年份:
    2019
  • 资助金额:
    $ 43.05万
  • 项目类别:
Dissecting Effects of Estrogen Deficiency on Satellite Cells and Muscle Regeneration in Females and Males
剖析雌激素缺乏对女性和男性卫星细胞和肌肉再生的影响
  • 批准号:
    10634732
  • 财政年份:
    2019
  • 资助金额:
    $ 43.05万
  • 项目类别:
Skeletal Muscle Stem Cells Derived from Teratomas
源自畸胎瘤的骨骼肌干细胞
  • 批准号:
    10627944
  • 财政年份:
    2019
  • 资助金额:
    $ 43.05万
  • 项目类别:
FSHD iPS Cells: Genetic Correction and Myogenesis
FSHD iPS 细胞:基因校正和肌生成
  • 批准号:
    8556649
  • 财政年份:
    2013
  • 资助金额:
    $ 43.05万
  • 项目类别:

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