Matching between codon usage and tRNA abundance determines the expression of targeting genes in mammalian cells

密码子使用和 tRNA 丰度之间的匹配决定了哺乳动物细胞中靶向基因的表达

• 批准号: nhmrc : 301256
• 负责人: Dr Kong-Nan Zhao
• 金额: $ 23.9万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/matching-codon-usage-mammalian-cells/113867
• 关键词: Matching; between; codon; usage; tRNA

This proposal is about optimal production of protein drugs (biopharmaceuticals), using genetic engineering in the laboratory and gene therapy in patients. It will explore the science behind a novel observation that the optimal way to use the genetic code to encode proteins for production varies from cell to cell in the lab, and from tissue to tissue in patients. If successful, a simple test can be used to decide the optimal genetic code for a specific application.

这项建议是关于蛋白质药物(生物制药)的最佳生产，在实验室使用基因工程，并在患者身上进行基因治疗。它将探索一种新的观察背后的科学，即使用遗传密码编码蛋白质以生产的最佳方式在实验室中因细胞而异，在患者的组织中也不同。如果成功，一个简单的测试就可以用来决定特定应用的最佳遗传密码。