Novel methods of acupuncture delivery in the treatment of drug-abuse disorders

针灸治疗药物滥用疾病的新方法

• 批准号: 9926706
• 负责人: Kyle Bills
• 金额: $ 8.04万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9926706
• 关键词: Ablation; Acupuncture Points; Acupuncture Therapy; Acute; Address; Alternative Medicine; Arbitration; Area; Behavioral Assay; Brain; Caring; Cervical spine; Chronic; Cocaine; Data; Disease; Drug abuse; Effectiveness; Electrophysiology (science); Exhibits; Exposure to; Frequencies; Goals; Healthcare; Implant; In Situ; Integrative Medicine; Investigative Techniques; Knowledge; Laboratories; Leg; Light; Literature; Locomotion; Measures; Mechanoreceptors; Medial; Mediating; Meissners Corpuscle; Merkel Cells; Methamphetamine; Methods; Microdialysis; Motor Activity; Naloxone; Neurologic; Neurons; Nucleus Accumbens; Opioid Antagonist; Opioid Receptor; Pacinian Corpuscles; Pathway interactions; Periodicity; Peripheral; Pharmaceutical Preparations; Publishing; Rattus; Research; Research Methodology; Research Personnel; Resources; Scanning; Scientist; Seasons; Self Administration; Site; Strategic Planning; Symptoms; Synapses; Testing; Time; Training; Transgenic Organisms; Ultrasonics; Universities; Ventral Tegmental Area; Venus; alcohol seeking behavior; cell type; clinical practice; cocaine exposure; compliance behavior; delta opioid receptor; density; dopaminergic neuron; dorsal column; drug reward; drug seeking behavior; effective therapy; gamma-Aminobutyric Acid; improved; improved outcome; in vivo; mesolimbic system; mu opioid receptors; naltrindole; neurophysiology; novel; optogenetics; receptor; response; subcutaneous; vibration; vocalization

PROJECT SUMMARY/ABSTRACT Though the use of HT7 acupuncture has been shown to reduce drug-seeking behavior, there are several barriers limiting its effectiveness. These include, pragmatically, the number and frequency of treatments required, patient adherence in light of high demands on time and resources and incomplete understanding of its underlying mechanisms. More knowledge and novel methods are needed to reduce these burdens and improve outcomes. A portion of the neurological pathway mediating these effects begins with activation of peripheral mechanoreceptors, which effect, after several synapses, the mesolimbic system. The aforementioned pathway forms the scientific premise of this proposal. We aim to test and define the mechanism of action of two novel methods of administering acupuncture; they are 1) subcutaneous vibratory implants and 2) optogenetic stimulation of peripheral mechanoreceptors. The overall hypothesis is that stimulation of peripheral mechanoreceptors, Meissner’s and Pacinian Corpuscles, via vibration or optogenics, will alter the mesolimbic activity and produce changes in the effects of acute cocaine administration. Further, that the effects will be reversed by ablation of the DCML pathway and/or administration (systemic or local) of naltrindole. This project allows the applicant exposure to important investigative techniques and seasoned researchers in the area of acupuncture and alternative medicine to facilitate a successful transition from clinical practice to full-time independent research. These include, in- vivo electrophysiology, fast-scan cyclic voltammetry, microdialysis, behavioral assays associated with drug seeking, optogenetics and access to on-site training in the labs of Scott Steffensen (BYU), Hee Young Kim (Daegu Haany University) and Jiang Ye (Rutgers). These laboratories have established themselves as leaders in this field and are ideally suited to provide world-class training. This project also meets several items of the NCCIH strategic plan, namely, to develop new research methods to improve understanding of complimentary healthcare approaches and hard-to-care for symptoms and to train clinician-scientists in the area of complimentary and integrative health research.

项目总结/文摘