Linking High-Risk Jail Detainees to HIV pre-exposure prophylaxis: PrEP-LINK

将高风险监狱被拘留者与艾滋病毒暴露前预防联系起来：PrEP-LINK

• 批准号: 9926737
• 负责人: Nickolas D Zaller
• 金额: $ 31.09万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9926737
• 关键词: AIDS prevention; Address; Adherence; African American; Alcohol or Other Drugs use; Area; Arkansas; Attitude; Caring; Chronic Disease; Communities; Community Health Aides; Counseling; County; Criminal Justice; Data; Discrimination; Education; Employment; Epidemic; Evaluation; Funding; Goals; HIV; HIV Infections; HIV Seronegativity; HIV risk; Health; High Prevalence; Housing; Imprisonment; Individual; Intervention; Interview; Jail; Knowledge; Link; Medical; Mental disorders; Participant; Pharmaceutical Preparations; Population; Poverty; Prevalence; Prisons; Provider; Quality of life; Randomized; Research; Research Personnel; Risk; Risk Factors; Services; Sexual Partners; Sexually Transmitted Diseases; Site; Social Work; Social support; Structure; System; Techniques; Tenofovir; Time; Treatment Efficacy; United States; United States National Institutes of Health; Work; arm; base; behavioral health; combat; effective intervention; efficacy testing; emtricitabine; experience; health care service; health disparity; high risk; high risk men; improved; informant; interest; men; men who have sex with men; minority health; multidisciplinary; novel; open label; pre-exposure prophylaxis; primary outcome; secondary outcome; sex; social; social disadvantage; standard of care; treatment arm; uptake; vision science

Abstract Criminal justice (CJ) involved individuals have extremely high prevalence of risk factors associated with HIV infection including poverty, substance use, transactional sex, high numbers of sex partners, high prevalence of sexually transmitted infections and mental illness. African Americans (AA) are at disproportionate risk for both incarceration and HIV infections. A growing body of evidence highlights the efficacy of a once daily medication, emtricitabine/tenofovir, also known as pre-exposure prophylaxis (PrEP), in reducing HIV acquisition. However, structural and social barriers can undermine optimal PrEP uptake, adherence, and retention in care and must be addressed especially among those with recent CJ experience. Our proposed study is directly aligned with NIMHD Science Visioning to advance intervention approaches to improve minority health or to reduce health disparities. Our proposed study will: provide a novel exploration of facilitators and barriers to PrEP; allow us to target hard to reach populations, including MSM and substance users (both of which are top funding priority groups for the National Institutes of Health) who experience intersecting markers of HIV risk; and inform regional, and possibly national, intervention approaches to combat the overlapping epidemic of HIV and incarceration: The specific aims of the project are: Aim 1: Perform a qualitative assessment of facilitators and barriers to PrEP uptake among high-risk jail detainees, systems and interactor levels; Aim 2: Develop the PrEP-LINK intervention and perform an open label evaluation with high-risk individuals being discharged from the Pulaski County Jail; Aim 3: Conduct a pilot RCT of the PrEP-LINK intervention among high-risk men being released from the Pulaski County Jail. Results will inform a subsequent multi-site RCT to test efficacy of the intervention in improving PrEP uptake, adherence, and retention in care among men with CJ-experience.

摘要