Tinnitus Treatment with Targeted Electric Stimulation

有针对性的电刺激治疗耳鸣

• 批准号: 9975629
• 负责人: Fan-Gang Zeng
• 金额: $ 32.83万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-16 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9975629
• 关键词: Acoustic Nerve; Acoustic Stimulation; Acoustics; Adhesives; Affect; American; Anxiety; Auditory; Auditory Perception; Basic Science; Biomedical Engineering; Charge; Clinical; Cochlear Implants; Cochlear implant procedure; Collaborations; Counseling; Development; Devices; Discontinuous Capillary; Disease; Ear; Electric Stimulation; Electrodes; Esthesia; External auditory canal; FDA approved; Gold; Hearing; Hearing Tests; Hour; Intervention; Knowledge; Lead; Loudness; Mastoid process; Measures; Medical; Medical Device; Mental Depression; Methods; National Institute on Deafness and Other Communication Disorders; Nature; Nerve Fibers; Neurosciences; Operative Surgical Procedures; Outcome; Patients; Pattern; Peripheral; Pharmaceutical Preparations; Physiologic pulse; Platinum; Principal Investigator; Procedures; Promontory; Protocols documentation; Public Health; Quality of life; Research Personnel; Research Project Grants; Services; Site; Sleep; Stimulus; Structure; Surface; Techniques; Tinnitus; Tragus; Translating; Tympanic membrane; Work; cost; daily functioning; disability; effective therapy; gang; hidden hearing loss; individual patient; innovation; minimally invasive; novel; programs; relating to nervous system; research and development; response; round window; skills; sound; tool

Principal Investigator/Program Director (Last, first, middle): Zeng, Fan-Gang Tinnitus is the perception of sound in the absence of external sound. Tinnitus is a significant public health problem that affects 50 million Americans. Severe tinnitus disrupts daily functions from sleep to work, often leading to anxiety, depression and lowered quality of life. Despite significant advances in research and development, presently there is no cure for tinnitus. The present application uses noninvasive electric stimulation in the ear and minimally-invasive electric stimulation to the round window or promontory for safe and effective treatment of tinnitus. One innovation is to evaluate stimulation sites and patterns that evoke auditory sensations while minimizing non-auditory sensations. Another innovation is to provide two novel tinnitus treatment options, especially for those who still have significant acoustic hearing and cite tinnitus, and not hearing loss, as the main indication. In the preliminary study, 10 minutes of round window stimulation completely silenced the tinnitus not only during stimulation but also for 5 hours after the stimulation in a subject who had suffered from tinnitus for 15 years. Successful completion of the present work can lead to safe and effective medical devices for tinnitus treatment. Project Summary

首席研究员/项目主任（后、一、中）：曾繁刚 耳鸣是在没有外部声音的情况下对声音的感知。耳鸣是一个重要的公众问题 影响 5000 万美国人的健康问题。严重耳鸣会扰乱从睡眠到日常功能 工作，常常导致焦虑、抑郁和生活质量下降。尽管取得了重大进展 研究和开发，目前还没有治愈耳鸣的方法。本申请使用 无创耳部电刺激和微创全身电刺激 安全有效治疗耳鸣的窗口或海角。一项创新是评估 刺激部位和模式能够唤起听觉，同时最大限度地减少非听觉。 另一项创新是提供两种新颖的耳鸣治疗选择，特别是对于那些仍然患有耳鸣的人 有明显的听觉，并以耳鸣而非听力损失作为主要指征。在 初步研究，10分钟圆窗刺激不仅完全消除耳鸣 对于患有耳鸣的受试者，在刺激期间以及刺激后 5 小时内 15年。成功完成目前的工作可以带来安全有效的医疗器械 用于耳鸣治疗。 项目概要