Cancer Biology Research Program

癌症生物学研究计划

• 批准号: 9975742
• 负责人: KRISTI L NEUFELD
• 金额: $ 2.49万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-11 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9975742
• 关键词: Affect; Animal Model; Area; BRAF gene; Basic Science; Behavior; Biochemical; Biochemistry; Biological; Biological Markers; Breast Sarcoma; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Etiology; Catchment Area; Cell Communication; Cell Proliferation; Cells; Cellular biology; Cessation of life; ChIP-seq; Characteristics; Chromatin; Clinical; Collaborations; Data; Development; Discipline; Disease; Drug Targeting; Faculty; Fostering; Funding; Genetic; Goals; Growth; Hematopoietic; Hematopoietic System; Incidence; Journals; Kansas; Kidney; Leadership; Libraries; Liver; Malignant - descriptor; Malignant Neoplasms; Metabolic syndrome; Methods; Molecular; Normal Cell; Oncogenic; Pathway interactions; Peer Review; Population; Prevention; Process; Publications; Publishing; Research; Research Personnel; Science; Signal Pathway; Signal Transduction; Site; Technology; Therapeutic; Time; Transcriptional Regulation; Translational Research; Tumor Cell Biology; Tumor Stem Cells; Tumor Suppressor Genes; United States National Institutes of Health; Universities; base; biochemical model; cancer cell; cancer prevention; cancer therapy; cell behavior; cell growth; cellular targeting; chromatin modification; clinical development; clinical practice; experience; gastrointestinal; in vitro Model; in vivo; inhibitor/antagonist; inter-institutional; interdisciplinary collaboration; interest; melanoma; member; mortality; neoplastic cell; next generation sequencing; novel; novel marker; novel strategies; preclinical development; programs; recruit; response; science education; small hairpin RNA; stem cell biology; symposium; therapeutic target; therapy development; transdifferentiation; translational research program; tumor; tumor metabolism; tumor progression

Cancer Biology – Project Summary The scientific goal of the Cancer Biology research program (CB) is to understand the molecular mechanisms that define normal and neoplastic cell growth in order to identify and characterize molecules, pathways and processes that are involved in tumor development, growth and progression that can serve as useful biomarkers and/or as new cellular targets for cancer therapeutics and prevention. CB represents the basic science initiatives of The University of Kansas Cancer Center (KUCC) and is unified by member utilization of molecular, biochemical and cell-based approaches to understand normal and cancer cell behavior. The Specific Aims of CB are: 1) to promote collaboration that enhances discovery of the mechanisms underlying tumor development, progression and malignant behavior; and 2) to leverage basic science discoveries to inspire pre-clinical and clinical development of novel cancer therapies. CB has 49 full members and 12 associate members from 17 departments located at KUMC, KU-Lawrence and Stowers. In 2015, CB garnered nearly $17M in cancer-related, peer-reviewed funding ($2M from NCI, $12.2M other NIH). CB members have published 617 articles since 2012 of which 144 (23%) had intra-programmatic, 128 (21%) had inter-programmatic and 315 (51%) had inter-institutional collaborations. These publications have been cited over 5,600 times, have an average journal impact factor (JIF) of 7.3 and 167 (27%) have a JIF≥8. CB is jointly led by Kristi Neufeld (KU-Lawrence) and Linheng Li (Stowers), who bring complementary scientific expertise in cell biology, stem cell biology, biochemistry and translational research, leadership experience and diverse institutional representation. Danny Welch, Associate Director for Basic Science & Education and Jim Calvet, KUCC Research Staff Investigator, round out the leadership team and represent KUMC. Intra- and inter-programmatic collaborations are fostered by research retreats, seminars, research symposia and targeted pilot funding. CB has taken advantage of historical strengths in the study of three tumor sites over-represented in either incidence or mortality rate in the KUCC catchment area population (GI, kidney and hematopoietic). But rather than a disease-based thematic organization, CB members have expertise that can be organized into four discipline-based themes: 1) Cancer Cell Biology and Stem Cell Biology; 2) Cell Proliferation, Differentiation and Death; 3) Chromatin Organization and Transcriptional Regulation; and 4) Signaling Pathways and Development.

癌症生物学——项目摘要 癌症生物学研究计划 (CB) 的科学目标是了解分子机制 定义正常和肿瘤细胞生长，以便识别和表征分子、途径和 参与肿瘤发生、生长和进展的过程可以起到有用的作用 生物标志物和/或作为癌症治疗和预防的新细胞靶点。 CB代表基本 堪萨斯大学癌症中心 (KUCC) 的科学倡议，并通过成员利用来统一 分子、生化和细胞方法来了解正常细胞和癌细胞的行为。这 CB 的具体目标是： 1) 促进合作，加强对潜在机制的发现 肿瘤的发生、进展和恶性行为； 2）利用基础科学发现 激发新型癌症疗法的临床前和临床开发。 CB 有 49 名正式会员和 12 名准会员，分别来自 KUMC、KU-Lawrence 和 KUMC 的 17 个部门。 斯托尔斯。 2015 年，CB 获得了近 1700 万美元的癌症相关同行评审资金（200 万美元来自 NCI，1220 万美元） 其他国家卫生研究院）。自 2012 年以来，CB 成员已发表 617 篇文章，其中 144 篇 (23%) 具有程序内、 128 个（21%）有计划间合作，315 个（51%）有机构间合作。这些出版物 被引用超过 5,600 次，平均期刊影响因子 (JIF) 为 7.3，并且 167 (27%) 的 JIF≥8。 CB 由 Kristi Neufeld (KU-Lawrence) 和 Linheng Li (Stowers) 共同领导，他们带来了互补 细胞生物学、干细胞生物学、生物化学和转化研究、领导力方面的科学专业知识 经验和多样化的机构代表性。丹尼·韦尔奇 (Danny Welch)，基础科学与技术副主任 Education 和 KUCC 研究人员 Jim Calvet 完善了领导团队并代表 KUMC。通过研究务虚会、研讨会、研究促进项目内和项目间合作 研讨会和有针对性的试点资金。 CB在三种肿瘤的研究中利用了历史优势 KUCC 流域人口（胃肠道、肾脏、 和造血）。但 CB 成员不是一个基于疾病的主题组织，而是拥有以下专业知识： 可分为四个学科主题：1）癌细胞生物学和干细胞生物学； 2) 细胞 增殖、分化和死亡； 3）染色质组织和转录调控；和 4) 信号通路和发展。