Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC)

匹兹堡艾滋病毒共病调查和治疗指导培训 (HIV MeTrICC)

基本信息

  • 批准号:
    9977276
  • 负责人:
  • 金额:
    $ 41.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-08-15 至 2023-06-30
  • 项目状态:
    已结题

项目摘要

ABSTRACT: Chronic sequelae of long-term HIV infection and treatment including heart, lung, blood, and sleep (HLBS) co-morbidities are increasingly important causes of morbidity and mortality. Latent HIV and maladaptive inflammation also persist despite successful ART. Therefore, we propose a new training program in HIV-related research, the Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC), led by Drs. Alison Morris, Dr. John Mellors, and Solomon Ofori-Acquah. They have an outstanding training record for PhDs and MDs, and their research experience spans the spectrum from basic to translational to clinical with expertise in lung, blood, and vascular co-morbidities and HIV cure. HIV MeTrICC will be an interdisciplinary, intensive mentored research training and career development experience focused around two interrelated training tracks – HLBS Co-morbidities and HIV Cure with the following objectives: 1) To provide intensive mentoring in HIV-associated HLBS Co-morbidities and HIV Cure. Our team of established Mentors will offer unique multidisciplinary mentoring and career guidance to Scholars in the conduct of HIV research projects. Scholars will choose Mentors from the MeTrICC Co-morbidities and HIV Cure tracks. Tracks will be highly interactive. 2) To provide didactic training to foster progression to an independent career in HIV-related research. Formal training will encompass a broad spectrum of research methodologies, technologies, and analytical approaches to basic, clinical, and translational HIV research. Scholars with varying levels of prior research experience will be supported by Individual Development Plans geared to their needs. 3) To provide opportunities for training in Inner-city HIV and International HIV settings. Scholars will be able to choose from two different focus areas if relevant to their career plan. For the Inner-city HIV focus, we partner with the University of Maryland and the NIH to provide experience with the District of Columbia Partnership for AIDS Progress, the nation’s largest urban HIV cohort study. For our International HIV focus, we utilize several sites in Africa with ongoing basic, clinical, and translational research. 4) To provide access to large, multi-center HIV studies: Scholars will have access to large cohort studies including the Multicenter AIDS Cohort Study, the Women’s Interagency HIV Study, the Strategic Timing of Antiretroviral Therapy pulmonary substudy, the Pittsburgh HIV Lung Research Cohort, and the Pharmacokinetic and Clinical Observations in People over 50 sleep Substudy. 5) To support scholars in preparation of an independent research proposal: The program will ensure that Scholars rapidly develop grant-writing skills and submit competitive grant applications to help them secure HIV research funding. We will support five post-doctoral Scholars (MDs and PhDs) for a period of 2 to 3 years based on initial level of experience (i.e. post-docs vs junior faculty). The success of the MeTrICC program will be measured by concrete milestones such first author manuscripts, grant funding, and transition to faculty with the ultimate goal to recruit a new generation of researchers to HIV and HLBS complications.
摘要:长期感染艾滋病毒的慢性后遗症和治疗包括心、肺、血和睡眠。 (HLBS)合并症是导致发病率和死亡率的日益重要的原因。潜伏的艾滋病毒和适应不良 尽管ART取得了成功,但炎症仍然存在。因此,我们提出了一个新的艾滋病毒相关培训计划 研究,匹兹堡艾滋病毒辅导性培训共病调查和治疗(HIV MeTrICC),领导 作者:艾莉森·莫里斯博士、约翰·梅勒斯博士和所罗门·奥弗里-阿卡。他们有出色的训练记录。 博士和医学博士,他们的研究经验涵盖了从基础到翻译再到临床的各个领域 精通肺部、血液和血管合并症和艾滋病毒治疗。HIV MeTrICC将是一个跨学科的, 密集的辅导式研究培训和职业发展经验围绕两个相互关联的 培训轨道--HLBS共病和艾滋病毒治疗,目标如下:1)提供强化培训 指导HIV相关的HLBS共病和HIV治疗。我们的资深导师团队将为您提供 在开展艾滋病毒研究项目方面为学者提供独特的多学科指导和职业指导。 学者们将从MeTrICC共同疾病和艾滋病毒治疗轨道中选择导师。赛道将高度 互动性。2)提供教学培训,以促进在艾滋病毒相关的独立职业生涯中取得进展 研究。正式培训将包括广泛的研究方法、技术和 基础、临床和转化性艾滋病毒研究的分析方法。不同学历的学者 研究经验将得到适合其需求的个人发展计划的支持。3)提供 在市内艾滋病毒和国际艾滋病毒环境中进行培训的机会。学者们将能够选择 来自两个不同的重点领域,如果与他们的职业规划相关。对于内城艾滋病毒焦点,我们与 马里兰大学和美国国立卫生研究院为哥伦比亚特区艾滋病伙伴关系提供经验 进步,全国最大的城市艾滋病毒队列研究。对于我们的国际艾滋病毒焦点,我们利用了几个网站 非洲正在进行的基础、临床和转化性研究。4)提供接触大型、多中心艾滋病毒的途径 研究:学者将可以获得大型队列研究,包括多中心艾滋病队列研究, 妇女机构间艾滋病毒研究,抗逆转录病毒治疗的战略时机肺子研究, 匹兹堡HIV肺部研究队列及50岁以上人群的药代动力学和临床观察 睡眠分组研究。5)支持学者准备独立研究提案:该计划 将确保学者们迅速发展赠款撰写技能并提交有竞争力的赠款申请,以帮助 他们获得了艾滋病毒研究资金。我们将支持五名博士后学者(医学博士和博士)为期一段时间 根据最初的经验水平(即博士后和初级教师),有2到3年的工作时间。MeTrICC的成功 该计划将通过具体的里程碑来衡量,如第一作者手稿、赠款资助和过渡到 最终目标是招募新一代研究艾滋病毒和HLBS并发症的研究人员。

项目成果

期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)

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John W Mellors其他文献

Long-acting antiretrovirals and HIV treatment adherence
长效抗逆转录病毒药物与 HIV 治疗依从性
  • DOI:
    10.1016/s2352-3018(23)00051-6
  • 发表时间:
    2023-05-01
  • 期刊:
  • 影响因子:
    13.000
  • 作者:
    Jean B Nachega;Kimberly K Scarsi;Monica Gandhi;Rachel K Scott;Lynne M Mofenson;Moherndran Archary;Sharon Nachman;Eric Decloedt;Elvin H Geng;Lindsay Wilson;Angeli Rawat;John W Mellors
  • 通讯作者:
    John W Mellors
Ritonavir and saquinavir combination therapy for the treatment of HIV infection.
利托那韦和沙奎那韦联合疗法用于治疗艾滋病毒感染。
  • DOI:
  • 发表时间:
    1999
  • 期刊:
  • 影响因子:
    0
  • 作者:
    William Cameron;A. Japour;Yi Xu;Ann Hsu;John W Mellors;Charles Farthing;Calvin Cohen;Donald Poretz;Martin Markowitz;Steve Follansbee;Jonathan B. Angel;D. McMahon;David Ho;V. Devanarayan;R. Rode;M. Salgo;Dale J. Kempf;R. Granneman;John M. Leonard;E. Sun
  • 通讯作者:
    E. Sun

John W Mellors的其他文献

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{{ truncateString('John W Mellors', 18)}}的其他基金

Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC)
匹兹堡艾滋病毒共病调查和治疗指导培训 (HIV MeTrICC)
  • 批准号:
    10223924
  • 财政年份:
    2018
  • 资助金额:
    $ 41.16万
  • 项目类别:
Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC)
匹兹堡艾滋病毒共病调查和治疗指导培训 (HIV MeTrICC)
  • 批准号:
    9764161
  • 财政年份:
    2018
  • 资助金额:
    $ 41.16万
  • 项目类别:
Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC)
匹兹堡艾滋病毒共病调查和治疗指导培训 (HIV MeTrICC)
  • 批准号:
    10430075
  • 财政年份:
    2018
  • 资助金额:
    $ 41.16万
  • 项目类别:
Longitudinal evaluation of HIV-associated lung disease phenotypes
HIV 相关肺部疾病表型的纵向评估
  • 批准号:
    8790587
  • 财政年份:
    2014
  • 资助金额:
    $ 41.16万
  • 项目类别:
Longitudinal evaluation of HIV-associated lung disease phenotypes
HIV 相关肺部疾病表型的纵向评估
  • 批准号:
    8913261
  • 财政年份:
    2014
  • 资助金额:
    $ 41.16万
  • 项目类别:
Simplified Assays of Latent But Inducible HIV-1 Reservoirs
潜在但可诱导的 HIV-1 储库的简化检测
  • 批准号:
    8766909
  • 财政年份:
    2014
  • 资助金额:
    $ 41.16万
  • 项目类别:
Simplified Assays of Latent But Inducible HIV-1 Reservoirs
潜在但可诱导的 HIV-1 储库的简化检测
  • 批准号:
    8885651
  • 财政年份:
    2014
  • 资助金额:
    $ 41.16万
  • 项目类别:
Longitudinal evaluation of HIV-associated lung disease phenotypes
HIV 相关肺部疾病表型的纵向评估
  • 批准号:
    9086463
  • 财政年份:
    2014
  • 资助金额:
    $ 41.16万
  • 项目类别:
University of Pittsburgh Clinical Trials Unit
匹兹堡大学临床试验单位
  • 批准号:
    8230290
  • 财政年份:
    2011
  • 资助金额:
    $ 41.16万
  • 项目类别:
IMPACT OF ANTIRETROVIRAL PREVENTION ON EMERGENCE AND SPREAD OF HIV DRUG RESISTA
抗逆转录病毒预防对艾滋病毒耐药性出现和传播的影响
  • 批准号:
    8171780
  • 财政年份:
    2010
  • 资助金额:
    $ 41.16万
  • 项目类别:

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