Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC)

摘要：长期HIV感染和治疗的慢性后遗症，包括心脏、肺、血液和睡眠 （HLBS）共病是发病率和死亡率的日益重要的原因。潜伏的艾滋病毒和适应不良 因此，我们提出了一个新的培训计划，在艾滋病毒相关的 研究，匹兹堡艾滋病毒辅导培训调查共病和治疗（艾滋病毒MeTrICC），领导 艾莉森·莫里斯博士、约翰·梅勒斯博士和所罗门·奥弗里-阿夸博士。他们有着出色的训练记录 博士和医学博士，他们的研究经验跨越了从基础到转化到临床的范围， 在肺部、血液和血管共病以及艾滋病毒治疗方面的专业知识。HIV MeTrICC将是一个跨学科的， 强化的指导研究培训和职业发展经验围绕两个相互关联的 培训轨道- HLBS合并症和艾滋病毒治疗，具有以下目标：1）提供密集的 艾滋病毒相关HLBS共病和艾滋病毒治疗方面的指导。我们的导师团队将提供 为学者开展艾滋病毒研究项目提供独特的多学科指导和职业指导。 学者将从MetrICC共病和艾滋病毒治疗轨道选择导师。轨道将高度 互动2)提供教学培训，以促进在艾滋病毒相关领域的独立职业发展 research.正式培训将包括广泛的研究方法，技术， 基础、临床和转化HIV研究的分析方法。具有不同程度的先验知识的学者 研究经验将由适合他们需要的个人发展计划支持。3)提供 在市内艾滋病毒和国际艾滋病毒环境的培训机会。学者们将能够选择 从两个不同的重点领域，如果相关的职业生涯规划。对于内城艾滋病毒的重点，我们与 马里兰州大学和国家卫生研究院提供与哥伦比亚特区艾滋病伙伴关系的经验 进步，全国最大的城市艾滋病毒队列研究。对于我们的国际艾滋病毒焦点，我们利用几个网站， 非洲与正在进行的基础，临床和转化研究。4)提供大型、多中心的艾滋病毒 研究：学者将有机会获得大型队列研究，包括多中心艾滋病队列研究， 妇女机构间艾滋病毒研究，抗逆转录病毒治疗肺亚组研究的战略时机， 匹兹堡HIV肺部研究队列，以及50岁以上人群的药代动力学和临床观察 睡眠子研究。5)支持学者准备独立的研究提案：该计划 将确保学者迅速发展赠款写作技能，并提交有竞争力的赠款申请，以帮助 他们获得了艾滋病研究资金。我们将支持五名博士后学者（MD和博士），为期 2至3年，根据初始经验水平（即博士后与初级教师）。MeTrICC的成功 该计划将通过具体的里程碑来衡量，如第一作者手稿，赠款资金和过渡到 教师的最终目标是招募新一代的研究人员艾滋病毒和HLBS并发症。

ABSTRACT: Chronic sequelae of long-term HIV infection and treatment including heart, lung, blood, and sleep (HLBS) co-morbidities are increasingly important causes of morbidity and mortality. Latent HIV and maladaptive inflammation also persist despite successful ART. Therefore, we propose a new training program in HIV-related research, the Pittsburgh HIV Mentored Training for Investigation of Co-morbidities and Cure (HIV MeTrICC), led by Drs. Alison Morris, Dr. John Mellors, and Solomon Ofori-Acquah. They have an outstanding training record for PhDs and MDs, and their research experience spans the spectrum from basic to translational to clinical with expertise in lung, blood, and vascular co-morbidities and HIV cure. HIV MeTrICC will be an interdisciplinary, intensive mentored research training and career development experience focused around two interrelated training tracks – HLBS Co-morbidities and HIV Cure with the following objectives: 1) To provide intensive mentoring in HIV-associated HLBS Co-morbidities and HIV Cure. Our team of established Mentors will offer unique multidisciplinary mentoring and career guidance to Scholars in the conduct of HIV research projects. Scholars will choose Mentors from the MeTrICC Co-morbidities and HIV Cure tracks. Tracks will be highly interactive. 2) To provide didactic training to foster progression to an independent career in HIV-related research. Formal training will encompass a broad spectrum of research methodologies, technologies, and analytical approaches to basic, clinical, and translational HIV research. Scholars with varying levels of prior research experience will be supported by Individual Development Plans geared to their needs. 3) To provide opportunities for training in Inner-city HIV and International HIV settings. Scholars will be able to choose from two different focus areas if relevant to their career plan. For the Inner-city HIV focus, we partner with the University of Maryland and the NIH to provide experience with the District of Columbia Partnership for AIDS Progress, the nation’s largest urban HIV cohort study. For our International HIV focus, we utilize several sites in Africa with ongoing basic, clinical, and translational research. 4) To provide access to large, multi-center HIV studies: Scholars will have access to large cohort studies including the Multicenter AIDS Cohort Study, the Women’s Interagency HIV Study, the Strategic Timing of Antiretroviral Therapy pulmonary substudy, the Pittsburgh HIV Lung Research Cohort, and the Pharmacokinetic and Clinical Observations in People over 50 sleep Substudy. 5) To support scholars in preparation of an independent research proposal: The program will ensure that Scholars rapidly develop grant-writing skills and submit competitive grant applications to help them secure HIV research funding. We will support five post-doctoral Scholars (MDs and PhDs) for a period of 2 to 3 years based on initial level of experience (i.e. post-docs vs junior faculty). The success of the MeTrICC program will be measured by concrete milestones such first author manuscripts, grant funding, and transition to faculty with the ultimate goal to recruit a new generation of researchers to HIV and HLBS complications.