Core A

核心A（管理核心）是一个大型核心，包括管理子组， 人力资源和数据分析/数据库建设。为了高效和集中地操作 作为总体中心，我们在Core A PI的领导下整合了这些不同的组件， 担任中心主任。该核心有三个主要目标：行政领导，组织 人类生物资源和数据组织/数据库维护。在目标1中，该核心将引领金融 管理、组织人类和动物受试者方案，并协调研究会议 和每年一度的静修该核心将通过以下方式为整个中心提供科学领导 集中组织科学问题，在中心内得出统一的结论，并协调 与中心外的研究人员进行合作研究和材料交流。这一核心将保持 网页的P50孔蒂中心，组织教育和推广计划。最后，这一核心将领导 以研究的严谨性和完整性为中心，确保成员遵守数据/资源共享政策。 在目标2中，该核心将组织并向中心研究者提供几种类型的既定人类 资源，包括用于遗传研究的三个病例对照样本集，来自 人脑、来自两个前瞻性队列样本的血液和人类诱导多能干细胞。在Aim中 3、该核心将继续开发一个数据库，其中项目中获得的多种类型的数据 将系统地存储，以支持研究者进行数据共享、分析和保存。这也是一 科学界内部的数据和资源共享以及公共宣传的基础。总的来说， 我相信，这一核心将继续发挥关键作用，提供中央服务，在行政 协调、组织人类生物资源和数据管理/数据库维护。这一核心 将代表中心领导研究的严谨性和完整性。我们将强调教育和公共 根据我们在目前的P50中建立的成功协议，我们正在制定外联计划。

The Core A (Administrative Core) is a large core that comprises sub-groups of administration, distinct resources of human materials, and data analyses/database construction. For efficient and central operation of the overall center, we have integrated these distinct components under the leadership of Core A PI, who also serves as the center director. This Core has three major aims: administrative leadership, organization of human bio-resources, and data organization/database maintenance. In Aim 1, this Core will lead financial administration, organization of human and animal subject protocols, and coordination of research meetings and annual retreat inside this Center. This Core will provide scientific leadership to the entire Center by centrally organizing scientific issues towards uniform conclusions inside the Center, and coordinating collaborative research and material exchange with investigators outside the Center. This Core will maintain the web page of the P50 Conte center, organize education and outreach plans. Lastly, this Core will lead the Center in research rigor and integrity and make sure the members to observe data/resource sharing policies. In Aim 2, this Core will organize and provide the center investigators with several types of established human resources, including three case-control sample sets for genetic study, the datasets of RNA-sequencing from human brains, blood from two prospective cohort samples, and human induced pluripotent stem cells. In Aim 3, this Core will continue development of a database in which the multiple types of data obtained in Projects will be systematically stored to support investigators for data sharing, analysis, and preservation. This is also a basis of data and resource sharing within the scientific community as well as public outreach. In summary, believe that this Core will continuously play a key role by providing the central service in administrative coordination, organization of human bio-resources, and data management/database maintenance. This core will lead research rigor and integrity on behalf of the Center. We will emphasize educational and public outreach plans, according to the successful protocol that we have built in the current P50.