MDM4: a new target for melanoma treatment
MDM4: a new target for melanoma treatment
批准号:
nhmrc : 1058897
负责人:
Prof Mark Shackleton
金额:
$44.38万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2018-12-31
中文摘要
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英文摘要
We recently discovered a new way to treat melanoma by inhibiting a protein called MDM4 that is important in promoting tumor growth in ~2/3 of melanomas. In this proposal, we will extend this work to see if anti-MDM4 therapy is effective in laboratory models that are more relevant to patients and in combination with other melanoma therapies. We will also explore additional ways of inhibiting MDM4 that may make anti-MDM4 therapy even more potent.
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Deciphering mechanisms of disease evolution in melanoma
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批准号:nhmrc : GNT1080253
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项目类别:Project Grants
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资助金额:$81.15万
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财政年份:2015
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负责人:Prof Mark Shackleton
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依托单位:
Deciphering mechanisms of disease evolution in melanoma
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批准号:nhmrc : 1080253
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项目类别:Project Grants
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资助金额:$56.35万
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财政年份:2015
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负责人:Prof Mark Shackleton
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依托单位:
The nature and significance of clonal evolution in human melanoma
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批准号:nhmrc : 1008790
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项目类别:NHMRC Project Grants
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资助金额:$44.37万
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财政年份:2011
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负责人:Prof Mark Shackleton
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依托单位:
The significance of cellular heterogeneity in melanoma
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批准号:nhmrc : 628735
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项目类别:Career Development Fellowships
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资助金额:$6.4万
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财政年份:2010
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负责人:Prof Mark Shackleton
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依托单位:
Cancer stem cells and melanoma pathogenesis
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批准号:nhmrc : 406679
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项目类别:Early Career Fellowships
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资助金额:$21.4万
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财政年份:2006
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负责人:Prof Mark Shackleton
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依托单位:
Transgenic models of mammary development and carcinogenesis
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批准号:nhmrc : 171609
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项目类别:NHMRC Postgraduate Scholarships
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资助金额:$6.54万
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财政年份:2001
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负责人:Prof Mark Shackleton
-
依托单位:
国内基金
海外基金
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