Kansas PKD Research and Translation Core Center

描述（由申请人提供）：堪萨斯PKD研究和翻译核心中心（主任：James Calvet）由行政核心，试点和可行性计划，教育充实计划和四个生物医学研究核心组成：基因靶向，表观遗传学，生物标志物和临床研究。在其基础上，该中心拥有活跃且不断增长的优秀PKD研究人员研究基地，并提出建立创新核心和强大的P&F计划，为新研究人员进入PKD领域并进行前沿研究提供机会。多囊肾病中心的使命是“促进研究，更好地了解多囊肾病，发现治疗靶点，开展临床试验，最终改善患者的预后。”本提案的中心主题是“PKD治疗发展的靶标识别”。堪萨斯PKD研究和翻译核心中心将通过实现以下四个具体目标来实现中心使命和中心主题所阐述的广泛目标：1)通过开发创新的生物医学研究核心来支持PKD在本地和全国的研究人员。2)建设一支熟练、协作、多学科的基础科学和临床研究研究者队伍。3)在学校内部建立伙伴关系，共享支持设施，并与合作机构建立伙伴关系。4)改善研究环境，以支持正在进行的项目和发展新的研究方向。

DESCRIPTION (provided by applicant): The Kansas PKD Research and Translation Core Center (Director: James Calvet) is comprised of an Administrative Core, Pilot & Feasibility Program, Educational Enrichment Program, and four Biomedical Research Cores: Gene Targeting, Epigenetics, Biomarkers, and Clinical Research. At its foundation, the Center has an active and growing research base of outstanding PKD investigators on which it proposes to build innovative cores and a robust P&F program providing opportunities for new investigators to enter the PKD field and to conduct cutting-edge research. The mission of the PKD Center is "The promotion of research leading to a better understanding of polycystic kidney disease and the discovery of targets for therapy and development of clinical trials ultimately for improved patient outcomes." The central theme of this proposal is "Target identification for PKD therapy development." The Kansas PKD Research and Translation Core Center will achieve the broad goals and objectives articulated by the center's mission and central theme by accomplishing these four specific aims: 1) To support PKD researchers locally and nationally by developing innovative biomedical research cores. 2) To develop a skilled, collaborative, multidisciplinary basic science and clinical research investigator base. 3) To develop partnerships within the institution, with shared support facilities, and with cooperating institutions. 4) To enhance the research environment to support ongoing projects and to develop new research directions.