Kansas PKD Research and Translation Core Center

堪萨斯 PKD 研究与翻译核心中心

• 批准号: 9984708
• 负责人: JAMES P CALVET
• 金额: $ 4.08万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9984708
• 关键词: Affect; Aortic Aneurysm; Automobile Driving; Basic Science; Biochemistry; Biological Markers; Biomedical Research; Blood; Cardiovascular system; Caring; Cell Culture Techniques; Cell physiology; Cells; Cellular biology; Cerebral Aneurysm; Clinical; Clinical Research; Clinical Trials; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communities; Consultations; Cyclic AMP; Cyst; Data; Databases; Defect; Development; Dialysis procedure; Disease; Disease Pathway; Drug Targeting; Educational process of instructing; Effectiveness; Environment; Epigenetic Process; Evaluation; Fluids and Secretions; Foundations; Gene Targeting; Genes; Goals; Grant; Growth; Heart Valves; Hereditary Disease; High Prevalence; Human Resources; Hypertension; Infrastructure; Institution; Interdisciplinary Study; Investigation; Kansas; Kidney; Kidney Failure; Liquid substance; Longterm Follow-up; Medical center; Mission; Morbidity - disease rate; Observational Study; Pathogenesis; Pathway interactions; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Physicians; Physiology; Polycystic Kidney Diseases; Population; Process; Proteins; Reagent; Recording of previous events; Renal tubule structure; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; Sampling; Scientist; Second Messenger Systems; Serum; Services; Signal Pathway; Signal Transduction; Site; Technology; Testing; Therapeutic; Training; Translational Research; Translations; Transplantation; United States National Institutes of Health; Universities; Urine; base; clinical development; cohort; cost; drug development; early childhood; epigenetic marker; exosome; improved; in vivo; innovation; insight; meetings; mortality; multidisciplinary; new technology; new therapeutic target; novel; novel therapeutics; patient oriented; patient/disease registry; programs; repository; research and development; specific biomarkers; success; symposium; targeted treatment; therapy development; tolvaptan; tool; transcription activator-like effector nucleases; translational medicine; urinary; user-friendly

DESCRIPTION (provided by applicant): The Kansas PKD Research and Translation Core Center (Director: James Calvet) is comprised of an Administrative Core, Pilot & Feasibility Program, Educational Enrichment Program, and four Biomedical Research Cores: Gene Targeting, Epigenetics, Biomarkers, and Clinical Research. At its foundation, the Center has an active and growing research base of outstanding PKD investigators on which it proposes to build innovative cores and a robust P&F program providing opportunities for new investigators to enter the PKD field and to conduct cutting-edge research. The mission of the PKD Center is "The promotion of research leading to a better understanding of polycystic kidney disease and the discovery of targets for therapy and development of clinical trials ultimately for improved patient outcomes." The central theme of this proposal is "Target identification for PKD therapy development." The Kansas PKD Research and Translation Core Center will achieve the broad goals and objectives articulated by the center's mission and central theme by accomplishing these four specific aims: 1) To support PKD researchers locally and nationally by developing innovative biomedical research cores. 2) To develop a skilled, collaborative, multidisciplinary basic science and clinical research investigator base. 3) To develop partnerships within the institution, with shared support facilities, and with cooperating institutions. 4) To enhance the research environment to support ongoing projects and to develop new research directions.

描述（由申请人提供）：堪萨斯PKD研究和翻译核心中心（主任：詹姆斯·卡尔维）由一个行政核心，试点和可行性计划，教育丰富计划和四个生物医学研究核心组成：基因靶向，表观遗传学，生物标志物和临床研究。在其基础上，该中心拥有一个活跃且不断增长的优秀PKD研究人员的研究基础，它建议建立创新核心和强大的P&F计划，为新的研究人员提供进入PKD领域并进行尖端研究的机会。PKD中心的使命是“促进研究，从而更好地了解多囊肾疾病，发现治疗靶点，并开发临床试验，最终改善患者的预后。该提案的中心主题是“PKD治疗发展的靶点识别“。“堪萨斯PKD研究和翻译核心中心将通过实现以下四个具体目标来实现该中心的使命和中心主题所阐述的广泛目标和目的：1）通过开发创新的生物医学研究核心来支持当地和全国的PKD研究人员。2)发展一个熟练的，协作的，多学科的基础科学和临床研究的研究者基地。3)在机构内发展伙伴关系，共享支助设施，并与合作机构建立伙伴关系。4)改善研究环境，以支持正在进行的项目，并开发新的研究方向。

项目成果

Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells.

• DOI: 10.1038/s41598-018-23341-2
• 发表时间: 2018-03-21
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Silva LM;Jacobs DT;Allard BA;Fields TA;Sharma M;Wallace DP;Tran PV
• 通讯作者: Tran PV

Glycogen synthase kinase-3β inhibits tubular regeneration in acute kidney injury by a FoxM1-dependent mechanism.

• DOI: 10.1096/fj.202000526rr
• 发表时间: 2020-10
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Sinha S;Dwivedi N;Woodgett J;Tao S;Howard C;Fields TA;Jamadar A;Rao R
• 通讯作者: Rao R

Epigenetics in kidney diseases.

• DOI: 10.1016/bs.acc.2020.09.005
• 发表时间: 2021
• 期刊: ADVANCES IN CLINICAL CHEMISTRY
• 作者: Ding, Hao;Zhang, Lu;Yang, Qian;Zhang, Xiaoqin;Li, Xiaogang
• 通讯作者: Li, Xiaogang