Population Assessment of Alzheimer's and Related Dementias in Rural Northern Peru

这项R21应用的总体目标是更好地了解认知障碍和痴呆症。 在秘鲁通贝斯的LMIC环境中，通过建立基于人口的认知状态基线， 在农村社区开展认知障碍和痴呆症研究。该地区有59个社区 参与了共同研究者对该应用程序进行的先前研究。为了实现这一目标，我们建议 目标1：确定秘鲁人认知障碍的范围、类型和患病率 生活在秘鲁北方农村的60岁或60岁以上;目标2a：启动一个基于人口的成年人队列， 在拉丁美洲农村地区，没有认知障碍，以促进未来的发病率和 目标2b：建立一个生物标志物和生物库核心， 信息和样本来自一个大型的农村人口为基础的队列拉丁美洲成年人不同程度的 认知障碍该提案将建立一个新的合作，以人口为基础， 在成熟的研究人群中进行认知障碍、痴呆和阿尔茨海默病的研究 在北方秘鲁与一组在痴呆症和人口健康方面经验丰富的调查人员。虽然 为本研究提出的研究工具是众所周知的，它们将提供有关 在一个独特的研究中， 北方秘鲁的拉丁美洲农村人口。我们将在该地区建立一个新的生物标志物核心， 为未来认知能力下降和痴呆症的研究提供了令人兴奋的机会。确定可改变的风险因素 可以提供治疗靶点和未来的机会，以更好地了解代谢的影响， 随着时间的推移认知。此外，通过获取有关残疾和生活质量的信息，我们将 能够更好地描述认知障碍和痴呆症对拉丁美洲农村的影响， 社区-目前没有的信息。

The overarching goal of this proposed R21 application is to better understand cognitive impairment and dementia in the LMIC setting of Tumbes, Peru through establishing a baseline of cognitive status for population-based studies of cognitive impairment and dementia in rural communities. Fifty-nine communities in this region have participated in prior research conducted by co-investigators on this application. To attain this goal, we propose the following specific aims: AIM 1: Define the spectrum, type and prevalence of cognitive impairment in Peruvians 60 years of age or older living in rural Northern Peru; AIM 2a: Initiate a population-based cohort of adults with and without cognitive impairment in rural Latin America to facilitate future longitudinal studies of incidence and prevention of cognitive decline and dementia; and Aim 2b: Establish a biomarker and biobanking core, containing information and samples from a large rural population-based cohort of Latin American adults with varying levels of cognitive impairment. This proposal would establish a new collaboration for population-based and clinical research in cognitive impairment, dementia and Alzheimer's disease in a well-established research population in northern Peru with a team of highly experienced investigators in dementia and population health. Although the research tools proposed for this study are well known, they would provide novel information regarding the prevalence of dementia and risk factors for cognitive impairment and dementia at a population-level in a unique rural Latin American population of Northern Peru. We will establish a novel biomarker core in this region with exciting opportunities for future studies of cognitive decline and dementia. Identification of modifiable risk factors could provide therapeutic targets and future opportunities to better understand the influence of metabolism upon cognition over time. In addition, through obtaining information regarding disabilities and quality of life, we will be able to better characterize the impact of cognitive impairment and dementia upon rural Latin American communities - information that currently is not available.