Population Assessment of Alzheimer's and Related Dementias in Rural Northern Peru

建议的R21应用的总体目标是更好地了解认知障碍和痴呆症 在秘鲁通贝斯的LMIC环境中，通过建立基于人群的认知状态基线 农村社区认知障碍和痴呆症研究。这一地区的59个社区 参与了联合调查员对这一应用程序进行的先前研究。为了实现这一目标，我们建议 以下具体目标：目标1：界定秘鲁人认知障碍的范围、类型和流行率 60岁或以上居住在秘鲁北部农村；目标2a：启动以人口为基础的成年人队列 并在拉丁美洲农村地区没有认知障碍，以促进未来对发病率和 预防认知衰退和痴呆症；以及目标2b：建立一个生物标志物和生物库核心，包括 信息和样本来自以农村人口为基础的大型拉丁美洲成年人队列，其水平各不相同 认知障碍的症状。这项提议将建立一个基于人群和临床的新合作 在公认的研究人群中进行认知障碍、痴呆症和阿尔茨海默病的研究 在秘鲁北部，拥有一支在痴呆症和人口健康方面经验丰富的调查团队。尽管 为这项研究提出的研究工具是众所周知的，它们将提供关于 在人群水平上的痴呆患病率以及认知损害和痴呆的危险因素 秘鲁北部的拉丁美洲农村人口。我们将在这个地区建立一个新的生物标志物核心 为认知衰退和痴呆症的未来研究提供了令人兴奋的机会。确定可更改的风险因素 可以提供治疗靶点和未来机会，以更好地了解新陈代谢对 随着时间的推移进行认知。此外，通过获取有关残疾和生活质量的信息，我们将 能够更好地描述认知障碍和痴呆症对拉丁美洲农村地区的影响 社区--当前不可用的信息。

The overarching goal of this proposed R21 application is to better understand cognitive impairment and dementia in the LMIC setting of Tumbes, Peru through establishing a baseline of cognitive status for population-based studies of cognitive impairment and dementia in rural communities. Fifty-nine communities in this region have participated in prior research conducted by co-investigators on this application. To attain this goal, we propose the following specific aims: AIM 1: Define the spectrum, type and prevalence of cognitive impairment in Peruvians 60 years of age or older living in rural Northern Peru; AIM 2a: Initiate a population-based cohort of adults with and without cognitive impairment in rural Latin America to facilitate future longitudinal studies of incidence and prevention of cognitive decline and dementia; and Aim 2b: Establish a biomarker and biobanking core, containing information and samples from a large rural population-based cohort of Latin American adults with varying levels of cognitive impairment. This proposal would establish a new collaboration for population-based and clinical research in cognitive impairment, dementia and Alzheimer's disease in a well-established research population in northern Peru with a team of highly experienced investigators in dementia and population health. Although the research tools proposed for this study are well known, they would provide novel information regarding the prevalence of dementia and risk factors for cognitive impairment and dementia at a population-level in a unique rural Latin American population of Northern Peru. We will establish a novel biomarker core in this region with exciting opportunities for future studies of cognitive decline and dementia. Identification of modifiable risk factors could provide therapeutic targets and future opportunities to better understand the influence of metabolism upon cognition over time. In addition, through obtaining information regarding disabilities and quality of life, we will be able to better characterize the impact of cognitive impairment and dementia upon rural Latin American communities - information that currently is not available.